List of works by Darren N Saunders

A high-throughput, multiplex cell death assay using an RNAi screening approach

scientific article

A novel SERPINA1 mutation causing serum alpha(1)-antitrypsin deficiency

scientific article

A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells

scientific article published on December 2007

Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration

scientific article published on 13 January 2017

Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer

scientific article published on 19 March 2017

Backlogged system in Australia shuts out new investigators

article

Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers.

scientific article published on 12 July 2016

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

scientific article published on 17 February 2017

Cancer in the news: Bias and quality in media reporting of cancer research

scientific article published on 09 November 2020

Correction: Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver

scientific article published on 8 September 2017

Crystal structure of the complex of plasminogen activator inhibitor 2 with a peptide mimicking the reactive center loop

scientific article

Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancer

scientific article

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

scientific article

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

scientific article

EDD mediates DNA damage-induced activation of CHK2

scientific article

Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion

scientific article published on August 2004

Effects of EDD on p53 function are context-specific

scientific article published on July 2011

Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives

scientific article

Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer

scientific article published on 13 October 2015

Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers.

scientific article

High-throughput approaches to measuring cell death

scientific article

Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases

scientific article published on 16 August 2016

Immunological Detection of Conformational Neoepitopes Associated with the Serpin Activity of Plasminogen Activator Inhibitor Type-2

scientific article published on 01 May 1998

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.

scientific article published on 30 August 2017

Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver

scientific article

Intensity calibration and automated cell cycle gating for high-throughput image-based siRNA screens of mammalian cells

scientific article

Interaction between the P14 residue and strand 2 of beta-sheet B is critical for reactive center loop insertion in plasminogen activator inhibitor-2.

scientific article

Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway

scientific article published on February 2013

Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta

scientific journal article

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

scientific article published on 01 June 2020

Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro

scientific article

Microsurgical access for cell injection into the mammalian cochlea

scientific article published on 22 September 2007

Mitochondrial mutations and metabolic adaptation in pancreatic cancer.

scientific article published on 30 January 2017

Modulation of myocardin function by the ubiquitin E3 ligase UBR5

scientific article published in 2011

Modulation of myocardin function by the ubiquitin E3 ligase UBR5.

scientific article

N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

scientific article published on 07 July 2020

Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro

scientific article published in 2008

Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity

scientific article published on January 2007

Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor

scientific article

Regulation of primary cilia formation by the ubiquitin-proteasome system

scientific article published on October 2016

Revisiting the biological roles of PAI2 (SERPINB2) in cancer

scientific article published on 12 June 2008

SOD1A4Vaggregation alters ubiquitin homeostasis in a cell model of ALS

scientific article published on 12 June 2018

Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer

scientific article

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

scientific article published on 17 June 2015

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

scientific article

Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.

scientific article published on April 2014

Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas

scientific article published on 19 October 2010

Systematic approaches to identify E3 ligase substrates

scientific article

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

scientific article

The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro

scientific article published on 18 March 2008

The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro.

scientific article

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

scientific article published on 13 June 2019

The Urokinase/PAI-2 Complex

scientific article published in Journal of Biological Chemistry

Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities.

scientific article published in March 2018

Walking the tightrope: proteostasis and neurodegenerative disease

scientific article published on 12 February 2016

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