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List of works by Steven R. Lentz

ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice.

scientific article published on 11 May 2017

ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice.

scientific article

AGXT2: a promiscuous aminotransferase

scientific article

Alternatively-spliced extra domain A of fibronectin promotes acute inflammation and brain injury after cerebral ischemia in mice.

scientific article published on 23 February 2012

Another lesson from the factor V Leiden mouse: thrombin generation drives arterial disease

scientific article published on 01 April 2005

Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys.

scientific article published in August 2002

Antiphospholipid Antibodies and Recurrent Thrombosis after a First Unprovoked Venous Thromboembolism.

scientific article published on 28 February 2018

ApoA-I: a missing link between homocysteine and lipid metabolism?

scientific article published in March 2006

Assessment of the impact of treatment on quality of life of patients with haemophilia A at different ages: insights from two clinical trials on turoctocog alfa

scientific article published on 29 January 2014

Case report: paroxysmal cold hemoglobinuria presenting during pregnancy.

scientific article

Cellular fibronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4

scientific article published on 19 February 2015

Cerebral vascular dysfunction during hypercholesterolemia

scientific article published on 24 May 2007

Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice.

scientific article

Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity

scientific article

Clinical and laboratory phenotype variability in type 2M von Willebrand disease

scientific article published on 20 May 2017

Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States

scientific article published on 09 February 2016

Clinical evaluation of glycoPEGylated recombinant FVIII: Efficacy and safety in severe haemophilia A.

scientific article published in December 2016

Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys.

scientific article published in November 1997

Countervailing effects on atherogenesis and plaque stability: a paradoxical benefit of hypercoagulability?

scientific article published on 17 August 2009

Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis

scientific article

D-dimer levels and recurrence in patients with unprovoked VTE and a negative qualitative D-dimer test after treatment

scientific article published on 23 June 2016

D-dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: a cohort study

scientific article published in January 2015

Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis

scientific article

Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia

scientific article

Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling.

scientific article

Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.

scientific article published on 21 January 2016

Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle

scientific article published on 27 February 2013

Durable responses to rituximab in acquired factor VIII deficiency

scientific article published on 05 May 2011

Effect of hyperhomocysteinemia on protein C activation and activity

scientific article published in September 2002

Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice.

scientific article published in December 2003

Effects of 1,2-dimethoxyethane on the catalytic and coenzyme properties of glycogen phosphorylase

scientific article published on 01 April 1981

Electronic communication at arteriosclerosis, thrombosis, and vascular biology

scientific article published on 01 August 2000

Endothelial PPAR-γ Protects Against Vascular Thrombosis by Downregulating P-Selectin ExpressionSignificance

scientific article (publication date: 12 February 2015)

Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.

scientific article published in June 2001

Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia.

scientific article published on 27 June 2006

Enhancing the pharmacokinetic properties of recombinant factor VIII: first-in-human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A.

scientific article

Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.

scientific article

Expression of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets

scientific article

Expression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous wounds

scientific journal article

Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor-cleaving protease activity.

scientific article published in January 2002

Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.

scientific article

Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice

scientific article published on 11 January 2018

Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4.

scientific article

Fixed doses of N8-GP prophylaxis maintain moderate-to-mild factor VIII levels in the majority of patients with severe hemophilia A

scientific article published on 11 June 2019

Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation

scientific article

Genetic testing to guide warfarin dosing: Impact of direct oral anticoagulants.

scientific article published on 14 May 2016

Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction.

scientific article

Haemophilia clinical care and research needs: Assessing priorities

scientific article published on 13 July 2018

Helicopter "Drip and Ship" Flights Do Not Alter the Pharmacological Integrity of rtPA

scientific article published on 20 July 2018

Homocysteine and vascular dysfunction.

scientific article

Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

scientific article

Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis

scientific article

Hyperhomocysteinemia increases arterial permeability and stiffness in mice

scientific article published on 22 June 2006

Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA.

scientific article published on December 2003

Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.

scientific article published on 30 October 2007

Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis.

scientific article

Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system

scientific article published on 01 July 1999

Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia.

scientific article published on 19 January 2006

Interim results from a large multinational extension trial (guardian(™) 2) using turoctocog alfa for prophylaxis and treatment of bleeding in patients with severe haemophilia A.

scientific article published on 13 June 2016

Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

scientific article published on 18 June 2009

Limit of detection and threshold for positivity of the Centers for Disease Control and Prevention assay for factor VIII inhibitors

scientific article published on 10 August 2017

Long-term patterns of safety and efficacy of bleeding prophylaxis with turoctocog alfa (NovoEight(®) ) in previously treated patients with severe haemophilia A: interim results of the guardian(™) 2 extension trial

scientific article published on 8 June 2015

Long-term safety and efficacy of turoctocog alfa in prophylaxis and treatment of bleeding episodes in severe haemophilia A: Final results from the guardian 2 extension trial

scientific article published on 06 November 2018

Malate dehydrogenase: isolation from E. coli and comparison with the eukaryotic mitochondrial and cytoplasmic forms.

scientific article

Mechanisms of the atherogenic effects of elevated homocysteine in experimental models.

scientific article

Mechanisms of thrombosis in obesity

scientific article published on September 2013

Murine models of hyperhomocysteinemia and their vascular phenotypes

scientific article published on 12 June 2008

Nonacog beta pegol (N9-GP) in haemophilia B: A multinational phase III safety and efficacy extension trial (paradigm™4).

scientific article published on 2 March 2016

On PAR with aPC to target inflammasomes.

scientific article published in December 2017

Once-weekly prophylaxis with glycoPEGylated recombinant factor VIII (N8-GP) in severe haemophilia A: Safety and efficacy results from pathfinder 2 (randomized phase III trial)

scientific article published on 28 February 2019

Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.

scientific article published on 6 December 2007

Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.

scientific article

Platelet factor 4 enhances generation of activated protein C in vitro and in vivo

scientific article published on 27 February 2003

Prospective, multicenter study of postoperative deep-vein thrombosis in patients with haemophilia undergoing major orthopaedic surgery

scientific article published on 24 March 2016

Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1.

scientific article published on 21 August 2017

Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia

scientific article

Protein methionine oxidation augments reperfusion injury in acute ischemic stroke

scientific article

Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.

scientific article published on March 2007

Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice

scientific article published on 02 November 2006

Recurrent neuroendocrine (Merkel cell) carcinoma of the skin presenting as marrow failure in a man with systemic lupus erythematosus

scientific article published on 01 January 1993

Regulation of thrombosis and vascular function by protein methionine oxidation

scientific article

Remission after 13-cis retinoic acid in thrombotic thrombocytopenic purpura

scientific article published on 01 August 1998

Results from a large multinational clinical trial (guardian™1) using prophylactic treatment with turoctocog alfa in adolescent and adult patients with severe haemophilia A: safety and efficacy.

scientific article

Role of FcRgamma and factor XIIIA in coated platelet formation

scientific article published on 16 August 2005

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease.

scientific article published in July 2004

Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen

scientific article published on 01 October 2002

Safety and efficacy of turoctocog alfa (NovoEight®) during surgery in patients with haemophilia A: results from the multinational guardian™ clinical trials.

scientific article

Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice

scientific journal article

Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys.

scientific article

Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels.

scientific article published on 30 May 2007

The benefits of excess EPCR

scientific article published on 01 July 2005

The homocysteine paradox.

scientific article published in June 2008

The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia

scientific article

The potential correlation between patient-reported symptoms and the use of additional haemostatic medication for joint bleeding in haemophilia patients with inhibitors: a post hoc exploratory analysis of recombinant activated factor VII data [...]

scientific article

The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis

scientific article published on 17 October 2017

Thrombosis in the setting of obesity or inflammatory bowel disease.

scientific article published on November 2016

Thrombosis in the setting of obesity or inflammatory bowel disease.

scientific article published on December 2016

Thrombosis of vein grafts: wall tension restrains thrombomodulin expression

scientific article published on 01 January 2003

Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.

scientific article published on 17 May 2005

Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.

scientific article published on 20 June 2008

Trends in clinical laboratory homocysteine testing from 1997 to 2010: the impact of evidence on clinical practice at a single institution.

scientific article published in March 2013

Turoctocog alfa pegol provides effective management for major and minor surgical procedures in patients across all age groups with severe haemophilia A: Full data set from the pathfinder 3 and 5 phase III trials

scientific article published on 15 April 2020

Von Willebrand Factor--A Rapid Sensor of Paravalvular Regurgitation during TAVR?

scientific article published in July 2016

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