List of works - Catherine M Greene

17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor

scientific article published on 8 April 2010

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.

scientific article published on 4 September 2008

Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin-binding proteins and studies on the expression of fnb genes.

scientific article published in September 1995

Airway Epithelium Dysfunction in Cystic Fibrosis and COPD.

scientific article

Airway Inflammatory/Immune Responses in COPD and Cystic Fibrosis.

scientific article published on 2 May 2018

Alpha-1 Antitrypsin-A Target for MicroRNA-Based Therapeutic Development for Cystic Fibrosis

scientific article published on 28 January 2020

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB.

scientific article published on 23 October 2017

Alpha-1 antitrypsin deficiency

scientific article published on 20 March 2010

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.

scientific article published on 16 January 2008

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.

scientific article

Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells.

scientific article published on 19 October 2009

Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease

scientific article published on 17 September 2009

Antimicrobial proteins and polypeptides in pulmonary innate defence

scientific article

Aspergillus-associated airway disease, inflammation, and the innate immune response

scientific article published on 21 July 2013

Assembly 3: Basic and Translational Sciences.

scientific article published in March 2018

Association of IL-10 polymorphism with severity of illness in community acquired pneumonia.

scientific article published in February 2003

Best of Milan 2017-ERS Lung Science Conference session "Lung tissue repair and remodeling in chronic lung diseases: mechanisms and therapeutic approaches".

scientific article published in November 2017

Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells

scientific article published on 3 July 2014

Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis.

scientific article published in July 2008

Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis

scientific article

Biopolymer-Based Nanoparticles for Cystic Fibrosis Lung Gene Therapy Studies

scientific article published on 13 January 2018

Candida species in cystic fibrosis: A road less travelled

scientific article

Challenges and future direction of molecular research in air pollution-related lung cancers

scientific article published on 31 January 2018

Challenges facing microRNA therapeutics for cystic fibrosis lung disease

scientific article published on 03 February 2020

Characterisation of the Major Extracellular Proteases of Stenotrophomonas maltophilia and Their Effects on Pulmonary Antiproteases

scientific article published on 28 June 2019

Chemical structure and biological activity of a highly branched (1 → 3,1 → 6)-β-D-glucan from Isochrysis galbana

scientific article

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.

scientific article

Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia?

scientific article published in March 2009

Cytokine responses to Staphylococcus aureus bloodstream infection differ between patient cohorts that have different clinical courses of infection

scientific article

Developmental control of CFTR: from bioinformatics to novel therapeutic approaches

scientific article published in January 2015

ERS International Congress 2022: highlights from the Basic and Translational Science Assembly

scientific article published in 2023

Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis

scientific article published on 20 May 2012

Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.

scientific article published on 4 October 2006

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.

scientific article

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis

scientific article published on 17 September 2008

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.

scientific article

Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis

scientific article published on 11 August 2005

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke

scientific article

Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency

scientific article published on 12 March 2010

Expression of X-linked Toll-like receptor 4 signaling genes in female vs. male neonates

scientific article published on 6 January 2017

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.

scientific article

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations

scientific article published on 15 December 2010

High-throughput profiling for discovery of non-coding RNA biomarkers of lung disease

scientific article

How can we target pulmonary inflammation in cystic fibrosis?

scientific article published on 30 March 2010

Identification of MiR-21-5p as a Functional Regulator of Mesothelin Expression Using MicroRNA Capture Affinity Coupled with Next Generation Sequencing

scientific article

Immune function? A missing link in the gender disparity in preterm neonatal outcomes

scientific article

In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens

scientific article published on 22 February 2011

Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor

scientific article

Innate Immunity of the Lung

scientific article published on 04 December 2019

Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine.

scientific article published on 13 February 2018

Innate immunity in cystic fibrosis lung disease

scientific article

Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA.

scientific article published on August 1999

Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?

scientific article

Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique

scientific article published on 15 January 2013

Knockdown of Gene Expression in Macrophages by microRNA Mimic-Containing Poly (Lactic-co-glycolic Acid) Microparticles.

scientific article published on 15 December 2018

LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline

scientific article published on 01 July 2009

Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia.

scientific article published on 14 August 2003

Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.

scientific article

Measurement of the unfolded protein response (UPR) in monocytes.

scientific article published in January 2011

MicroRNA Dysregulation in Cystic Fibrosis

scientific article (publication date: 2015)

MicroRNAs and liver cancer associated with iron overload: therapeutic targets unravelled

scientific article published on August 2013

MicroRNAs in inflammatory lung disease--master regulators or target practice?

scientific article published on 28 October 2010

Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells.

scientific article

Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.

scientific article

Non-coding RNA as lung disease biomarkers

scientific article published on 30 December 2014

Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis.

scientific article published on 25 November 2013

Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery

scientific article published on October 2009

Protein quality control in lung disease: it's all about cloud networking

scientific article published on October 2014

Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway

scientific article

Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung

scientific article published on 31 March 2011

Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia

scientific article

Reduced pro-inflammatory responses to Staphylococcus aureus bloodstream infection and low prevalence of enterotoxin genes in isolates from patients on haemodialysis.

scientific article published on 9 September 2016

Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ΔF508 cystic fibrosis airway epithelium

scientific article published on 22 February 2013

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide

scientific article

SLPI and inflammatory lung disease in females

scientific article published on October 2011

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.

scientific article

Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding

scientific article

Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells

scientific article

Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination.

scientific article published on 25 June 2002

Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency

scientific article published on 27 April 2009

Sexual maturation protects against development of lung inflammation through estrogen.

scientific article published on 25 November 2015

Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2.

scientific article

Systematic evaluation of the microRNAome through miR-CATCHv2.0 identifies positive and negative regulators of BRAF-X1 mRNA

scientific article published on 19 April 2019

Targeting miRNA-based medicines to cystic fibrosis airway epithelial cells using nanotechnology

scientific article published on 11 October 2013

Targeting neutrophil elastase in cystic fibrosis

scientific article published on 01 February 2008

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.

scientific article

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity

scientific article published on 12 July 2015

The Estrogen-Induced miR-19 Downregulates Secretory Leucoprotease Inhibitor Expression in Monocytes

scientific article published on 02 July 2019

The Role of Short-Chain Fatty Acids, Produced by Anaerobic Bacteria, in the Cystic Fibrosis Airway

scientific article published on 12 August 2015

The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis

scientific article published on 17 September 2015

The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis.

scientific article

The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency

scientific article published on June 2011

Therapeutic aerosol bioengineering of siRNA for the treatment of inflammatory lung disease by TNFα gene silencing in macrophages

scientific article

Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.

scientific article published on March 2012

Toll-Like Receptors in Cystic Fibrosis: Impact of Dysfunctional microRNA on Innate Immune Responses in the Cystic Fibrosis Lung.

scientific article published on 5 April 2016

Toll-like receptors as therapeutic targets in cystic fibrosis

scientific article published on 01 December 2008

Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease

scientific article

Transforming Growth Factor-β1 Selectively Recruits microRNAs to the RNA-Induced Silencing Complex and Degrades CFTR mRNA under Permissive Conditions in Human Bronchial Epithelial Cells

scientific article published on 05 October 2019

Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia.

scientific article published on 14 November 2002

Ursodeoxycholic acid inhibits TNFα-induced IL-8 release from monocytes

scientific article published on 23 June 2016

Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.

scientific article published on 03 February 2012

Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis

scientific article published on 23 July 2011

X Chromosome-encoded MicroRNAs Are Functionally Increased in Cystic Fibrosis Monocytes.

scientific article

Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant

scientific article

Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response

scientific article

miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression

scientific article

miR-17 overexpression in cystic fibrosis airway epithelial cells decreases interleukin-8 production

scientific article published on 9 July 2015

miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency.

scientific article published in February 2014

miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production

scientific article

miR-CATCH Identifies Biologically Active miRNA Regulators of the Pro-Survival Gene XIAP, in Chinese Hamster Ovary Cells

scientific article

miR-CATCH: microRNA capture affinity technology

scientific article published on January 2015

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6.

scientific article published on 7 January 2015

microRNA regulatory circuits in a mouse model of inherited retinal degeneration

scientific article

microRNAs in asthma: potential therapeutic targets

scientific article published on January 2013

α1-Antitrypsin deficiency.

scientific article published on 28 July 2016

List of works by Catherine M Greene

17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.

Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin-binding proteins and studies on the expression of fnb genes.

Airway Epithelium Dysfunction in Cystic Fibrosis and COPD.

Airway Inflammatory/Immune Responses in COPD and Cystic Fibrosis.

Alpha-1 Antitrypsin-A Target for MicroRNA-Based Therapeutic Development for Cystic Fibrosis

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB.

Alpha-1 antitrypsin deficiency

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.

Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells.

Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease

Antimicrobial proteins and polypeptides in pulmonary innate defence

Aspergillus-associated airway disease, inflammation, and the innate immune response

Assembly 3: Basic and Translational Sciences.

Association of IL-10 polymorphism with severity of illness in community acquired pneumonia.

Best of Milan 2017-ERS Lung Science Conference session "Lung tissue repair and remodeling in chronic lung diseases: mechanisms and therapeutic approaches".

Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells

Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis.

Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis

Biopolymer-Based Nanoparticles for Cystic Fibrosis Lung Gene Therapy Studies

Candida species in cystic fibrosis: A road less travelled

Challenges and future direction of molecular research in air pollution-related lung cancers

Challenges facing microRNA therapeutics for cystic fibrosis lung disease

Characterisation of the Major Extracellular Proteases of Stenotrophomonas maltophilia and Their Effects on Pulmonary Antiproteases

Chemical structure and biological activity of a highly branched (1 → 3,1 → 6)-β-D-glucan from Isochrysis galbana

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.

Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia?

Cytokine responses to Staphylococcus aureus bloodstream infection differ between patient cohorts that have different clinical courses of infection

Developmental control of CFTR: from bioinformatics to novel therapeutic approaches

ERS International Congress 2022: highlights from the Basic and Translational Science Assembly

Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis

Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.

Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke

Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency

Expression of X-linked Toll-like receptor 4 signaling genes in female vs. male neonates

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations

High-throughput profiling for discovery of non-coding RNA biomarkers of lung disease

How can we target pulmonary inflammation in cystic fibrosis?

Identification of MiR-21-5p as a Functional Regulator of Mesothelin Expression Using MicroRNA Capture Affinity Coupled with Next Generation Sequencing

Immune function? A missing link in the gender disparity in preterm neonatal outcomes

In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens

Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor

Innate Immunity of the Lung

Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine.

Innate immunity in cystic fibrosis lung disease

Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA.

Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?

Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique

Knockdown of Gene Expression in Macrophages by microRNA Mimic-Containing Poly (Lactic-co-glycolic Acid) Microparticles.

LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline

Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia.

Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.

Measurement of the unfolded protein response (UPR) in monocytes.

MicroRNA Dysregulation in Cystic Fibrosis

MicroRNAs and liver cancer associated with iron overload: therapeutic targets unravelled

MicroRNAs in inflammatory lung disease--master regulators or target practice?

Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells.

Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.

Non-coding RNA as lung disease biomarkers

Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis.

Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery

Protein quality control in lung disease: it's all about cloud networking

Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway

Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung

Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia

Reduced pro-inflammatory responses to Staphylococcus aureus bloodstream infection and low prevalence of enterotoxin genes in isolates from patients on haemodialysis.

Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ΔF508 cystic fibrosis airway epithelium

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide

SLPI and inflammatory lung disease in females

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.

Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding

Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells

Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination.