List of works - Richard D Wainford

A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin

scientific article

Across the globe in 4 months: two International Society of Hypertension new investigator symposia in 2014.

scientific article

Angiotensin AT2 receptors and the baroreflex control of renal sympathetic nerve activity.

scientific article

Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus

scientific article published on 10 January 2012

Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial

scientific article published on 13 July 2020

Brain Gαi 2 -subunit proteins and the prevention of salt sensitive hypertension

scientific article

Brain Gαi2-subunit protein-gated pathways are required to mediate the centrally evoked sympathoinhibitory mechanisms activated to maintain sodium homeostasis ⬇️

scientific article published on April 1, 2013

Brain heterotrimeric Gαi 2 ‐subunit protein‐gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress ⬇️

scientific article published on March 29, 2012

Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats

scientific article published on 4 June 2008

Central Nervous System Gαi 2 -Subunit Proteins Maintain Salt Resistance via a Renal Nerve–Dependent Sympathoinhibitory Pathway ⬇️

scientific article published on December 3, 2012

Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system.

scientific article

Correction: Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.

scientific article published in October 2015

Functional selectivity of central Gα-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central α(2) -adrenoceptor activation in vivo

scientific journal article

Gαi2-protein-mediated signal transduction: central nervous system molecular mechanism countering the development of sodium-dependent hypertension

scientific article

How to Reduce Dietary Salt Intake: Just Add Spice?

scientific article published on 31 October 2017

Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats

scientific article published on July 2015

Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats.

scientific article

Hypothalamic signaling mechanisms in hypertension.

scientific article

Impact of global versus renal-specific sympathoinhibition in aldosterone-induced hypertension: implications for medical device-based treatment of resistant hypertension.

scientific article published on 20 April 2015

Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Gαi2 proteins.

scientific article published on 27 September 2015

In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor

scientific article

Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Gαi2 protein-dependent, salt-sensitive hypertension

scientific article published on 20 October 2019

Mechanisms of Altered Renal Sodium Handling in Age-Related Hypertension.

scientific article published on 14 February 2018

Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats.

scientific article published on 25 November 2015

Presympathetic neuron dysfunction--time to reconsider increased intrinsic activity as the cause of neurogenic hypertension.

scientific article published on July 2014

Renal Afferents

scientific article

Renal sodium handling and sodium sensitivity

scientific article

Role of the afferent renal nerves in sodium homeostasis and blood pressure regulation in rats

scientific article published on 27 May 2019

List of works by Richard D Wainford

A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin

Across the globe in 4 months: two International Society of Hypertension new investigator symposia in 2014.

Angiotensin AT2 receptors and the baroreflex control of renal sympathetic nerve activity.

Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus

Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial

Brain Gαi 2 -subunit proteins and the prevention of salt sensitive hypertension

Brain Gαi2-subunit protein-gated pathways are required to mediate the centrally evoked sympathoinhibitory mechanisms activated to maintain sodium homeostasis ⬇️

Brain heterotrimeric Gαi 2 ‐subunit protein‐gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress ⬇️

Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats

Central Nervous System Gαi 2 -Subunit Proteins Maintain Salt Resistance via a Renal Nerve–Dependent Sympathoinhibitory Pathway ⬇️

Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system.

Correction: Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.

Functional selectivity of central Gα-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central α(2) -adrenoceptor activation in vivo

Gαi2-protein-mediated signal transduction: central nervous system molecular mechanism countering the development of sodium-dependent hypertension

How to Reduce Dietary Salt Intake: Just Add Spice?

Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats

Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats.

Hypothalamic signaling mechanisms in hypertension.

Impact of global versus renal-specific sympathoinhibition in aldosterone-induced hypertension: implications for medical device-based treatment of resistant hypertension.

Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Gαi2 proteins.

In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor

Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Gαi2 protein-dependent, salt-sensitive hypertension

Mechanisms of Altered Renal Sodium Handling in Age-Related Hypertension.

Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats.

Presympathetic neuron dysfunction--time to reconsider increased intrinsic activity as the cause of neurogenic hypertension.

Renal Afferents

Renal sodium handling and sodium sensitivity

Role of the afferent renal nerves in sodium homeostasis and blood pressure regulation in rats