Search filters

List of works by Nicolas Chomont

641Acute Retroviral Syndrome is Associated with Gut Mucosal CD4 Depletion, Inflammation and High Viral and Proviral Burden in Systemic and Tissue Compartments.

scientific article published in December 2014

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

scientific article

A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'anti-memory' effect by exploiting the baseline oxidative status of lymphocytes.

scientific article published on 5 December 2013

A novel acute HIV infection staging system based on 4th generation immunoassay

scientific article published on 29 May 2013

Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection

scientific article published on 01 March 2020

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

scientific article (publication date: October 2014)

Acute Retroviral Syndrome is Associated with High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments

scientific article published on 7 December 2017

An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription

scientific article

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy

scientific article

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals

article

Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site

scientific article published on 13 April 2016

Association of Arterial and Lymph Node Inflammation With Distinct Inflammatory Pathways in Human Immunodeficiency Virus Infection

scientific article published on 07 December 2016

Binding of LFA-1 (CD11a) to intercellular adhesion molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells

scientific article

CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy

scientific article published on 22 October 2011

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.

scientific article

CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells

scientific article

Cervicovaginal secretory antibodies to human immunodeficiency virus type 1 (HIV-1) that block viral transcytosis through tight epithelial barriers in highly exposed HIV-1-seronegative African women.

scientific article

Combination Immune Checkpoint Blockade to Reverse HIV Latency

scientific article published on 27 January 2020

Comparison of washing and swabbing procedures for collecting genital fluids to assess shedding of human immunodeficiency virus type 1 (HIV-1) RNA in asymptomatic HIV-1-infected women

scientific article

Compartmentalization of HIV-1 between Breast Milk and Blood of HIV-Infected Mothers

article

Conference highlights of the 5th international workshop on HIV persistence during therapy, 6-9 December 2011, St. Maartin, West Indies

scientific article published on 12 March 2012

Cross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studies

scientific article

DNA/MVA Vaccination of HIV-1 Infected Participants with Viral Suppression on Antiretroviral Therapy, followed by Treatment Interruption: Elicitation of Immune Responses without Control of Re-Emergent Virus

scientific article

Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection.

scientific article published on February 2017

Design and Implementation of a Randomized Crossover Study of Valproic Acid and Antiretroviral Therapy to Reduce the HIV Reservoir ⬇️

scientific article published on November 1, 2012

Detection of Y chromosome DNA as evidence of semen in cervicovaginal secretions of sexually active women.

scientific article

Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size

scientific article

Down-regulation of CTLA-4 by HIV-1 Nef protein

scientific article published on 23 January 2013

Drug resistance mutations and the cellular immune response: a valuable synergy for the development of novel immune therapies

scientific article published on March 2007

Early archives of genetically-restricted proviral DNA in the female genital tract after heterosexual transmission of HIV-1.

scientific article published in January 2007

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol

article

Enterovirus RNA shedding in the genital tract of childbearing-aged women living in Central Africa

scientific article published in May 2006

Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques

scientific article published on 4 November 2010

Erratum: Corrigendum: Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

article

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir

article published in the Proceedings of the National Academy of Sciences of the United States of America

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study.

scientific article published on 28 November 2017

Finding a cure for HIV: will it ever be achievable?

scientific article

Fingolimod inhibits multiple stages of the HIV-1 life cycle

scientific article published on 13 August 2020

Genetic and phenotypic features of blood and genital viral populations of clinically asymptomatic and antiretroviral-treatment-naive clade a human immunodeficiency virus type 1-infected women.

scientific article published on 25 April 2007

Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension

scientific article published in July 2011

HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART.

scientific article published on 20 July 2016

HIV antibody characterization as a method to quantify reservoir size during curative interventions

scientific article

HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals

scientific article published on July 2010

HIV persistence in mucosal CD4+ T cells within the lungs of adults receiving long-term suppressive antiretroviral therapy

article

HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?

scientific article

HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy

scientific article

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

scientific article (publication date: August 2009)

HIV-1 Reservoir Dynamics after Vaccination and Antiretroviral Therapy Interruption Are Associated with Dendritic Cell Vaccine-Induced T Cell Responses

scientific article

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.

scientific article published on 7 November 2017

High levels of CD2 expression identify HIV-1 latently infected resting memory CD4+ T cells in virally suppressed subjects.

scientific article published on 12 June 2013

Highlights from the 8th International Workshop on HIV Persistence during Therapy, 12-15 December 2017, Miami, FL, USA.

scientific article published in April 2018

Highlights from the Seventh International Workshop on HIV Persistence during Therapy, 8-11 December 2015, Miami, Florida, USA

scientific article

How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?

scientific article

Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy

scientific article published on March 2017

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.

scientific article published in October 2017

Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach

scientific article

Immune activation and HIV persistence: implications for curative approaches to HIV infection

scientific article

Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults

scientific article published on 24 September 2016

Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection

scientific article

Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically suppressive combination antiretroviral therapy

scientific article

Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically-suppressive cART.

scientific article

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

scientific article published on 17 June 2021

Independent levels of cell-free and cell-associated human immunodeficiency virus-1 in genital-tract secretions of clinically asymptomatic, treatment-naive African women

scientific article published on 29 July 2003

Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise

scientific article published on 17 January 2018

Infrequent HIV Infection of Circulating Monocytes during Antiretroviral Therapy

scientific article published on 12 December 2019

Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation

scientific article published on 15 September 2016

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

scientific article

Interleukin-7 promotes HIV persistence during antiretroviral therapy

scientific article published on 15 April 2013

International AIDS Society global scientific strategy: towards an HIV cure 2016.

scientific article published on 11 July 2016

Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy

scientific article published on 01 November 2019

Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques

scientific article

Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.

scientific article

Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection

scientific article published on June 2008

L’inhibition de la voie PD-1 permet de restaurer les fonctions effectrices des lymphocytes spécifiques du VIH

scientific article published on 01 January 2007

Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV.

scientific article published on January 2011

Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification

scientific article published on April 2015

Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique

scientific article published on 7 September 2017

Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation

scientific article

Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound

scientific article published on 17 March 2020

Neutralizing monoclonal antibodies to human immunodeficiency virus type 1 do not inhibit viral transcytosis through mucosal epithelial cells

scientific article

New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy

scientific article published on 24 August 2016

Opposite Effects of IL-10 on the Ability of Dendritic Cells and Macrophages to Replicate Primary CXCR4-Dependent HIV-1 Strains

article

Opsonization of HIV with complement enhances infection of dendritic cells and viral transfer to CD4 T cells in a CR3 and DC-SIGN-dependent manner

scientific article

Opsonization of HIV-1 by semen complement enhances infection of human epithelial cells

scientific article (publication date: 15 September 2002)

Oral cannabinoids in people living with HIV on effective antiretroviral therapy: CTN PT028-study protocol for a pilot randomised trial to assess safety, tolerability and effect on immune activation

article

P16-54 LB. Blood CCR6+ Th17 and Th1Th17 but not CCR6neg Th1 cells are targets for HIV replication and their frequency is diminished in HIV-infected subjects

article

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4 T cells from ART-suppressed individuals

article

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy

scientific article published on 14 December 2020

Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy

scientific article published on 26 January 2022

Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection

scientific article

Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy

scientific article published on 23 January 2016

Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection

scientific article

Polymerase chain reaction for Y chromosome to detect semen in cervicovaginal fluid: a prerequisite to assess HIV-specific vaginal immunity and HIV genital shedding

article

Potent suppression of HIV viral replication by a novel inhibitor of Tat.

scientific article published on 25 May 2012

Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection

scientific article published on 6 September 2012

Programmed cell death-1 contributes to the establishment and maintenance of HIV-1 latency

article

Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections

scientific article published on May 2007

Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection.

scientific article published on 05 August 2013

Purging the HIV-1 reservoir through the disruption of the PD-1 pathway.

scientific article

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

article

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

scientific article published on 07 September 2020

Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children

scientific article published on April 2014

Residual inflammation and viral reservoirs: alliance against an HIV cure

scientific article

Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial

scientific article published on 15 April 2019

Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption

scientific article published on 23 March 2020

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals

scientific article

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

scientific article published on 14 August 2020

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

article

Strategies for targeting residual HIV infection

scientific article published on July 2016

Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity

scientific article published in 2024

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

scientific article published on 17 September 2015

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

scientific article published on 7 July 2015

The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid

scientific article

The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research

scientific article published in October 2017

The immunological synapse: the gateway to the HIV reservoir

scientific article

The role of cytokines in the establishment, persistence and eradication of the HIV reservoir

scientific article published on 27 June 2012

Towards an HIV cure: a global scientific strategy

scientific article

Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection

scientific article published on 2 March 2008

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

scientific article

Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.

scientific article

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

scientific article published on December 2015

Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection

scientific article published on January 2016

Wake me up before you go: A strategy to reduce the latent HIV reservoir

scientific article published on 10 November 2017

Paulina is supported by:

About Paulina

Help