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List of works by Matthijs Verhage

A 1-night operant learning task without food-restriction differentiates among mouse strains in an automated home-cage environment

scientific article

A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity

scientific article published on 21 February 2020

A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells

scientific article

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

scientific article published on 01 May 2019

A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice.

scientific article published on 15 February 2017

A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion

scientific article

A solution to dependency: using multilevel analysis to accommodate nested data

scientific article

AHCODA-DB: a data repository with web-based mining tools for the analysis of automated high-content mouse phenomics data

scientific article

Activity-dependent recruitment of endogenous glutamate for exocytosis ⬇️

scientific article published on January 1, 1991

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

scientific article published on 14 April 2015

Automated analysis of neuronal morphology, synapse number and synaptic recruitment

scientific article published on 15 December 2010

Automated analysis of secretory vesicle distribution at the ultrastructural level.

scientific article published on 5 June 2008

Automated quantification of cellular traffic in living cells.

scientific article

Ba2+ replaces Ca2+/calmodulin in the activation of protein phosphatases and in exocytosis of all major transmitters

scientific article published on 01 November 1995

Bidirectional modulation of classical fear conditioning in mice by 5-HT(1A) receptor ligands with contrasting intrinsic activities.

scientific article published on 15 July 2009

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons

scientific journal article

CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons

scientific article published on 7 September 2017

Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane.

scientific article published on 21 March 2004

Ca2+-dependent regulation of presynaptic stimulus-secretion coupling

scientific article published on 01 October 1989

CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles

scientific article published on 10 August 2020

Characterization of the release of Met-enkephalin from isolated nerve terminals: release kinetics and cation-dependence

scientific article published on December 11, 1992

Characterization of the release of cholecystokinin-8 from isolated nerve terminals and comparison with exocytosis of classical transmitters.

scientific article

Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures.

scientific article published in September 2009

Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin

scientific article published on 24 May 2016

Complex Genetics of Behavior: BXDs in the Automated Home-Cage.

scientific article published in January 2017

Conformational switch of syntaxin-1 controls synaptic vesicle fusion

scientific article

Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

scientific article published on 4 June 2015

Correction: CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.

scientific article published on 18 November 2015

Correction: MUNC18-1 regulates the submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in β-sheet 10 (doi:10.1242/jcs.234674)

scientific article published on 16 December 2019

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article

Crashpilot Underachieves due to Acetylation at the Nerve Terminal ⬇️

scientific article published on 01 December 2011

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

scientific article published on 9 July 2014

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties

scientific article published on 3 March 2006

Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality.

scientific article

Dendritic position is a major determinant of presynaptic strength.

scientific article published on 9 April 2012

Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.

scientific article published on 27 November 2017

Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion

scientific journal article

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons.

scientific article

Differential distribution and regulation of expression of synaptosomal-associated protein of 25 kDa isoforms in the Xenopus pituitary gland and brain.

scientific article

Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice

Display of individuality in avoidance behavior and risk assessment of inbred mice

scientific article

Dissecting docking and tethering of secretory vesicles at the target membrane.

scientific article published on 10 August 2006

Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons

scientific article published on 25 February 2020

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.

scientific article published on 23 December 2017

Doc2b Ca2+ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength

scientific article published on 08 October 2019

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

scientific article

Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity

scientific article

Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release

scientific article published in October 2013

Docking of secretory vesicles is syntaxin dependent

scientific article

Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25.

scientific article published on 27 March 2017

Endogenous noradrenaline and dopamine in nerve terminals of the hippocampus: differences in levels and release kinetics.

scientific article published in September 1992

Evaluation of the Ca2+ concentration in purified nerve terminals: relationship between Ca2+ homeostasis and synaptosomal preparation

scientific article published on 01 December 1988

Extension of Helix 12 in Munc18-1 Induces Vesicle Priming.

scientific article published on June 2016

FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain

scientific article

Fast vesicle fusion in living cells requires at least three SNARE complexes

scientific article published on 16 September 2010

Fatty acids add grease to exocytosis

scientific article published in May 2005

Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.

scientific article

Finding the right motivation: genotype-dependent differences in effective reinforcements for spatial learning

scientific article

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

scientific article published on June 2015

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.

scientific article

Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability

scientific article

Functional gene-set analysis does not support a major role for synaptic function in attention deficit/hyperactivity disorder (ADHD).

scientific article published on 22 July 2014

Gene-set analysis shows association between FMRP targets and autism spectrum disorder

scientific article

Genes encoding heterotrimeric G-proteins are associated with gray matter volume variations in the medial frontal cortex

scientific article published on 17 April 2012

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

scientific article published in October 2013

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

scientific article published on 27 August 2019

Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission

scientific article published on 01 February 2020

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

scientific article published on 20 December 2017

Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes

scientific article published on 21 February 2015

Interdependence of PKC-dependent and PKC-independent pathways for presynaptic plasticity

scientific article

Joint reanalysis of 29 correlated SNPs supports the role of PCLO/Piccolo as a causal risk factor for major depressive disorder

scientific article published on 01 July 2009

Kindling increases the K(+)-evoked Ca2(+)-dependent release of endogenous GABA in area CA1 of rat hippocampus.

scientific article published in March 1990

Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission

scientific article published on September 2013

Loss of MUNC18-1 leads to retrograde transport defects in neurons

scientific article published on 01 December 2020

MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

scientific article published on 4 April 2018

MUNC18-1 regulates the submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in β-sheet 10

scientific article published on 02 December 2019

Matrix-dependent local retention of secretory vesicle cargo in cortical neurons

scientific article published in January 2009

Measuring discrimination- and reversal learning in mouse models within 4 days and without prior food deprivation.

scientific article

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

scientific article

Molecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretion

scientific article

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells.

scientific article

Multilevel analysis quantifies variation in the experimental effect while optimizing power and preventing false positives

scientific article published on 19 December 2015

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats? ⬇️

scientific article published on 09 August 2011

Munc13 controls the location and efficiency of dense-core vesicle release in neurons

scientific article

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

scientific article

Munc18 and Munc13 regulate early neurite outgrowth

scientific article

Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

scientific journal article

Munc18-1 in secretion: lonely Munc joins SNARE team and takes control.

scientific article published on 22 October 2007

Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release

scientific article

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.

scientific article

Munc18-1 phosphorylation by protein kinase C potentiates vesicle pool replenishment in bovine chromaffin cells.

scientific article published on 25 September 2006

Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner

scientific article published on March 2014

Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms

scientific article

Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation

scientific article

Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming.

scientific article published on August 2007

Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.

scientific article published on 2 May 2015

Neurobeachin regulates neurotransmitter receptor trafficking to synapses.

scientific article published on 31 December 2012

Neurodegeneration: new road leads back to the synapse.

scientific article

Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.

scientific article

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

scientific article published on 05 February 2020

Organelle docking: R-SNAREs are late.

scientific article

Perfusion of immobilized isolated nerve terminals as a model for the regulation of transmitter release: release of different, endogenous transmitters, repeated stimulation, and high time resolution

scientific article published on April 1, 1992

Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studies

scientific article

Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity

scientific article published on 18 April 2016

Pool size estimations for dense-core vesicles in mammalian CNS neurons

scientific article published on 05 September 2018

Power in GWAS: lifting the curse of the clinical cut-off.

scientific article

Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.

scientific article published on 07 April 2016

Presynaptic plasticity: the regulation of Ca(2+)-dependent transmitter release.

scientific article published on March 1994

Presynaptic signal transduction pathways that modulate synaptic transmission.

scientific article published on 24 June 2009

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy

scientific article published in May 2018

Publisher Correction: Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner

scientific article published on 22 November 2019

Quantification of synapse formation and maintenance in vivo in the absence of synaptic release

scientific journal article

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article published on 16 January 2018

Rab3 Proteins Involved in Vesicle Biogenesis and Priming in Embryonic Mouse Chromaffin Cells

scientific article published on 03 September 2010

Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals.

scientific article published on October 2001

Reduced Protein Stability of 11 Pathogenic Missense STXBP1/MUNC18-1 Variants and Improved Disease Prediction

scientific article published in 2024

Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.

scientific article

Reduced synaptic depression in human neurons carrying homozygous disease-causing <i>STXBP1</i> variant L446F

scientific article published in 2024

Regulated exocytosis: merging ideas on fusing membranes.

scientific article published on 16 July 2007

Role of Munc18-1 in synaptic plasticity at the myasthenic neuromuscular junction

scientific article published on 01 September 2003

SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering

scientific article published on 01 August 2019

SNAP-25 gene family members differentially support secretory vesicle fusion.

scientific article published on 12 April 2017

SNAREopathies: Diversity in Mechanisms and Symptoms

scientific article published on 12 June 2020

Secretory vesicle trafficking in awake and anaesthetized mice: differential speeds in axons versus synapses

scientific article published on 01 July 2018

Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring

scientific article

Somatodendritic secretion in oxytocin neurons is upregulated during the female reproductive cycle.

scientific article published in April 2003

Spatial, contextual and working memory are not affected by the absence of mossy fiber long-term potentiation and depression.

scientific article published in January 2003

Supporting the generalist genes hypothesis for intellectual ability/disability: the case of SNAP25.

scientific article published on 28 July 2012

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

scientific article published on 03 June 2019

Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.

scientific article

Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons

scientific article published on 25 September 2015

Synaptic assembly of the brain in the absence of neurotransmitter secretion

scientific article

Synaptobrevin, Sphingolipids, and Secretion: Lube ‘n’ Go at the Synapse

scientific article published on 01 June 2009

Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.

scientific article

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

scientific article published on 27 August 2009

Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner

scientific article published on 05 August 2019

TRIM3 regulates the motility of the kinesin motor protein KIF21B

scientific article (publication date: 2013)

Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons

scientific article published on 02 July 2020

Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action ⬇️

scientific article published on October 25, 1992

The Action Radius of Oxytocin Release in the Mammalian CNS: From Single Vesicles to Behavior

scientific article

The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.

scientific article published on August 2014

The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

scientific article published on 31 October 2019

The SNARE protein vti1a functions in dense-core vesicle biogenesis

scientific article published on 5 June 2014

The light spot test: Measuring anxiety in mice in an automated home-cage environment

scientific article

The role of Munc18-1 in docking and exocytosis of peptide hormone vesicles in the anterior pituitary.

scientific article published in June 2005

The role of Rab3a in secretory vesicle docking requires association/dissociation of guanidine phosphates and Munc18-1.

scientific article

The role of calcium and cAMP in the mechanism of action of two melanocortins: alpha MSH and the ACTH4-9 analogue Org 2766

scientific article published on 01 October 1994

Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.

scientific article published on 26 July 2017

Tomosyn interacts with the SUMO E3 ligase PIASγ.

scientific article

Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.

scientific article

Trophic support delays but does not prevent cell-intrinsic degeneration of neurons deficient for munc18-1

scientific journal article

Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.

scientific article

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.

scientific article published on 17 November 2017

Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons

scientific article published in Scientific Reports

Vesicle docking in regulated exocytosis.

scientific article published on 28 April 2008

Vesicle trafficking: pleasure and pain from SM genes.

scientific article

Vesicular trafficking of semaphorin 3A is activity-dependent and differs between axons and dendrites.

scientific article

Vti Proteins: Beyond Endolysosomal Trafficking

scientific article published on 22 November 2018

Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi

scientific article published in Nature Communications

Within-strain variation in behavior differs consistently between common inbred strains of mice

scientific article published on 28 June 2015

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