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List of works by John S. Lazo

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway

scientific article

22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

scientific article published on 22 January 2003

A Cdc25A antagonizing K vitamin inhibits hepatocyte DNA synthesis in vitro and in vivo

scientific article

A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos ⬇️

scientific article published on April 13, 2011

A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis

scientific article

A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

scientific article

A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells

scientific article

A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

article

A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity

scientific article published on January 2004

A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity

scientific article

Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells

scientific article published on January 2004

Airing out an antioxidant role for the tumor suppressor p53.

scientific article published in February 2006

Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome ⬇️

scientific article published on October 4, 2012

Anti-leishmanial drug discovery: rising to the challenges of a highly neglected disease

scientific article published on April 2010

Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity

scientific article

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

scientific article

Automated image-based phenotypic analysis in zebrafish embryos

scientific article

Binding and inhibition of Cdc25 phosphatases by vitamin K analogues

scientific article published on September 2003

Biological evaluation of newly synthesized quinoline-5,8-quinones as Cdc25B inhibitors

scientific article published on 16 June 2006

Building a pharmacological lexicon: small molecule discovery in academia

scientific article

Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library

scientific article published in June 2009

Cell division cycle 25B phosphatase is essential for benzo(a)pyrene-7,8-Diol-9,10-epoxide induced neoplastic transformation

scientific article published in October 2007

Cell-active dual specificity phosphatase inhibitors identified by high-content screening

scientific article published on August 2003

Cell-active dual specificity phosphatase inhibitors identified by high-content screening

scientific article published on January 2005

Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product

scientific article published in January 2006

Changes and challenges--the world post-Gleevec (Glivec).

scientific article

Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.

scientific article

Chemical complementation: a definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets

scientific article published in August 2005

Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis

scientific article published on March 2007

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds

scientific article

Compound Acquisition and Prioritization Algorithm for Constructing Structurally Diverse Compound Libraries ⬇️

scientific article published on April 18, 2011

Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

scientific article published on 15 July 2008

Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches

scientific article published on 12 March 2018

Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice

scientific article published on 27 May 2014

Design, Synthesis, and Biological Evaluation of PKD Inhibitors

scientific article

Designing, optimizing, and implementing high-throughput siRNA genomic screening with glioma cells for the discovery of survival genes and novel drug targets

scientific article

Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells

scientific article

Development and Validation of a High-Content Screening Assay to Identify Inhibitors of Cytoplasmic Dynein-Mediated Transport of Glucocorticoid Receptor to the Nucleus ⬇️

scientific article published on July 25, 2012

Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors

scientific article

Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1.

scientific article

Development and optimization of high-throughput in vitro protein phosphatase screening assays

scientific article

Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents

scientific article published on August 2008

Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries

scientific article

Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C.

scientific article published on September 2005

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids

scientific article

Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase

scientific article

Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity

scientific article

Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model

scientific article published on March 2009

Discovery of protein kinase phosphatase inhibitors.

scientific article

Drug discovery algorithm for cutaneous leishmaniasis

scientific article

Drugging Undruggable Molecular Cancer Targets

scientific article

Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione

scientific article

Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease

scientific article

Dual-specificity phosphatases as targets for antineoplastic agents

scientific article

Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

scientific article published on 05 April 2020

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity

scientific article

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

scientific article

Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells

scientific article

Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone

scientific article published on October 2005

Functional genomic analysis of glioblastoma multiforme through short interfering RNA screening: a paradigm for therapeutic development

scientific article

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines

scientific article

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

scientific article

Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp.

scientific article published on February 2005

High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines

scientific article published in January 2018

High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines

scientific article

Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21.

scientific article

Identification of Chemosensitivity Nodes for Vinblastine through Small Interfering RNA High-Throughput Screens ⬇️

scientific article published on August 31, 2011

Identification of Druggable Targets for Radiation Mitigation Using a Small Interfering RNA Screening Assay ⬇️

scientific article published on July 2, 2012

Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors

scientific article published in April 2002

Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase

scientific article (publication date: 31 May 2002)

Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen

scientific article

Identification of survival genes in human glioblastoma cells by small interfering RNA screening

scientific article published on 25 September 2009

Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.

scientific article

Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review

scientific article

Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits

scientific article

Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases

scientific article

Improved low molecular weight Myc-Max inhibitors

scientific article

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization ⬇️

scientific article published on August 26, 2010

In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors

scientific article published on 01 February 2019

Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone

scientific article published on 3 October 2006

Induction of Cdc25B regulates cell cycle resumption after genotoxic stress

scientific article published on April 2007

Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents

scientific article

Is Cdc25 a druggable target?

scientific article published on December 2008

Low molecular weight inhibitors of Myc-Max interaction and function

scientific article published on September 2003

MKP-8, a novel MAPK phosphatase that inhibits p38 kinase

scientific article

Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta

scientific article

Microtubule binding and disruption and induction of premature senescence by disorazole C(1).

scientific article published on 09 December 2008

Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.

scientific article

Molecular Biology and Anticancer Drug Discovery

scientific article published on January 1, 2010

Molecular Interventions (2001-2011): An Experiment Completed

scientific article published on April 1, 2011

Multimodal control of Cdc25A by nitrosative stress

scientific article published on September 2008

Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor ⬇️

scientific article published on May 1, 2011

NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors

scientific article published on 12 January 2004

New Approaches to Difficult Drug Targets: The Phosphatase Story

New glycolipid inhibitors of Myt1 kinase

Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

scientific article published on 10 October 2019

Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition

scientific article published on 10 January 2009

Normal-phase and stability-indicating reversed-phase high-performance liquid chromatographic methods for the determination of the novel antitumor agent: 1-methylpropyl-2-imidazolyldisulfide

scientific article published in March 2002

Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1.

scientific article

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility

scientific article published on 5 May 2010

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors

scientific article

Optimization of ultrasound contrast agents with computational models to improve selection of ligands and binding strength ⬇️

scientific article published on December 1, 2010

PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells

scientific article published on January 2007

Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death

scientific article

Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284).

scientific article published on September 2007

Pharmacology goes phlat: molecular interventions feels the impact.

scientific article

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target ⬇️

scientific article published on September 1, 2012

Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics

scientific article

Phosphatases as targets for cancer treatment.

scientific article published on December 2009

Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

scientific article

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone

scientific article

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

scientific article

Protein kinase D as a potential new target for cancer therapy

scientific article

Protein phosphorylation in cultured endothelial cells

Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility

scientific article

Rear-view mirrors and crystal balls: a brief reflection on drug discovery.

scientific article

Redox regulation of Cdc25B by cell-active quinolinediones

scientific article

Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis

scientific article published on 28 September 2017

Refining Radiation for the Next Century

scientific article published in February 2018

Sesterterpenoids and an alkaloid from a Thorectandra sp. as inhibitors of the phosphatase Cdc25B.

scientific article

Sleuthful pharmacology

scientific article published in August 2003

Small Molecule Regulation of Phosphatase-Dependent Cell Signaling Pathways ⬇️

scientific article published on January 1, 2003

Small molecule targeting of PTPs in cancer

scientific article published on 21 September 2017

Solubility, ionization, and partitioning behavior of unsymmetrical disulfide compounds: alkyl 2-imidazolyl disulfides

scientific article

Strategies for discovery of small molecule radiation protectors and radiation mitigators

scientific article

Structurally unique inhibitors of human mitogen-activated protein kinase phosphatase-1 identified in a pyrrole carboxamide library

scientific article

Structure of the complex of an iminopyridinedione PTP4A3 phosphatase inhibitor with human serum albumin

scientific article published on 25 September 2020

Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D

scientific article

Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors

scientific article

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.

scientific article

Synthesis and biological evaluation of caulibugulones A-E.

scientific article

Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector

scientific article published in October 2009

Systems cell biology knowledge created from high content screening

scientific article published in October 2005

Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer

scientific article

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

scientific article published on 30 December 2017

Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype

scientific article published on 30 July 2012

The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity.

scientific article published in September 2002

The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

scientific article published on 7 March 2005

The carcinogen (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces Cdc25B expression in human bronchial and lung cancer cells

scientific article published in February 2003

The hubris and humility of cancer pharmacology in the post immuno-oncology era

scientific article published on 08 October 2019

The substrate recognition domains of the N-end rule pathway

scientific article

Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening

scientific article

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

scientific article

microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells

scientific article published on 13 October 2009

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