List of works - Helena Danielson

Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis

article

Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors.

scientific article published in July 2003

Biomolecular recognition of glycosylated β3-peptides by GalNAc specific lectins

scholarly article by Anna S. Norgren published in January 2007

Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

scientific article

Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+ /calmodulin-dependent kinase II

scientific article published on 27 April 2017

Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors.

scientific article published in April 2006

Biosensor-based screening and characterization of HIV-1 inhibitor interactions with Sap 1, Sap 2, and Sap 3 from Candida albicans.

scientific article published on 17 January 2006

Biotinylated lipid bilayer disks as model membranes for biosensor analyses.

scientific article

Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor.

scientific article published on 10 May 2009

Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation.

scientific article published on September 2006

Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.

scientific article published on 11 December 2017

Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

scientific article published on March 1990

Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.

scientific article published on March 1997

Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors. Use of L-mannaric acid as a peptidomimetic scaffold

scientific article published on September 1998

Development of a Radiochemical Cyclooxygenase-1 and -2 in Vitro Assay for Identification of Natural Products as Inhibitors of Prostaglandin Biosynthesis

article

Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

scientific article

Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands.

scientific article published on 17 June 2010

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

scientific article published on 17 February 2021

Early Absorption and Distribution Analysis of Antitumor and Anti-AIDS Drugs: Lipid Membrane and Plasma Protein Interactions

article

Effect of the Protonation State of the Titratable Residues on the Inhibitor Affinity to BACE-1

article published in 2010

Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.

scientific article published on 19 October 2007

Establishing Trypanosoma cruzi farnesyl pyrophosphate synthase as a viable target for biosensor driven fragment-based lead discovery

scientific article published on 07 February 2020

Estimating Detection Limits of Potentiometric DNA Sensors Using Surface Plasmon Resonance Analyses

scientific article published on 23 December 2019

Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors.

scientific article

Experimental and ‘in silico’ analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

scientific article published in 2012

Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3.

scientific article published on 5 October 2005

HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases.

scientific article published on April 2002

Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.

scientific article

Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors.

scientific article

Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs ⬇️

scientific article published on November 1, 1997

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents.

scientific article

Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data.

scientific article

Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process.

scientific article

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein.

scientific article published on September 2010

Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance.

scientific article

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.

scientific article published on 21 February 2018

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII.

scientific article published on 25 January 2016

MIV-170, A Novel NNRTI Exhibiting Tight Binding to HIV-1 Reverse Transcriptase (RT)

article

Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors.

scientific article

Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

article

On the Active Site Protonation State in Aspartic Proteases: Implications for Drug Design ⬇️

scientific article published on January 1, 2013

P2–P1′ macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis ⬇️

scientific article published on June 28, 2011

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold.

scientific article

Peptide-based inhibitors of hepatitis C virus full-length NS3 (protease-helicase/NTPase): model compounds towards small molecule inhibitors.

scientific article published in July 2003

Probing the Kinetic Mechanism and Coenzyme Specificity of Glutathione Reductase from the CyanobacteriumAnabaenaPCC 7120 by Redesign of the Pyridine-Nucleotide-Binding Site†

scientific article published in 1999

Quantification of interactions between drug leads and serum proteins by use of “binding efficiency”

article published in 2011

Refolding of the full-length non-structural protein 3 of hepatitis C virus.

scientific article published in June 2005

Screening for NNRTIs with slow dissociation and high affinity for a panel of HIV-1 RT variants.

scientific article

Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology.

scientific article

Sensitivity analysis and error structure of progress curves

scientific article published in 2006

Structural Changes of Mercaptohexanol Self-Assembled Monolayers on Gold and Their Influence on Impedimetric Aptamer Sensors

scientific article published on 07 November 2019

Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

scientific article

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors.

scientific article published in April 2004

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication

scientific article

Structure–activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V ⬇️

scientific article published on January 1, 2010

Studies of substrate-induced conformational changes in human cytomegalovirus protease using optical biosensor technology.

scientific article

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

scientific article

Synthesis and Comparative Molecular Field Analysis (CoMFA) of Symmetric and Nonsymmetric Cyclic Sulfamide HIV-1 Protease Inhibitors

article

Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors

scientific article

Synthesis ofC2Symmetric Potential Inhibitors of HIV-1 Protease From D-Mannitol

article

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors – characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors

scientific article

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

scientific article published on 10 February 2022

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

scientific article published on 21 August 2019

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

scientific article published on December 2014

List of works by Helena Danielson

Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis

Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors.

Biomolecular recognition of glycosylated β3-peptides by GalNAc specific lectins

Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+ /calmodulin-dependent kinase II

Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors.

Biosensor-based screening and characterization of HIV-1 inhibitor interactions with Sap 1, Sap 2, and Sap 3 from Candida albicans.

Biotinylated lipid bilayer disks as model membranes for biosensor analyses.

Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor.

Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation.

Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.

Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.

Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors. Use of L-mannaric acid as a peptidomimetic scaffold

Development of a Radiochemical Cyclooxygenase-1 and -2 in Vitro Assay for Identification of Natural Products as Inhibitors of Prostaglandin Biosynthesis

Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands.

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

Early Absorption and Distribution Analysis of Antitumor and Anti-AIDS Drugs: Lipid Membrane and Plasma Protein Interactions

Effect of the Protonation State of the Titratable Residues on the Inhibitor Affinity to BACE-1

Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.

Establishing Trypanosoma cruzi farnesyl pyrophosphate synthase as a viable target for biosensor driven fragment-based lead discovery

Estimating Detection Limits of Potentiometric DNA Sensors Using Surface Plasmon Resonance Analyses

Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors.

Experimental and ‘in silico’ analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3.

HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases.

Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.

Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors.

Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs ⬇️

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents.

Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data.

Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process.

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein.

Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance.

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII.

MIV-170, A Novel NNRTI Exhibiting Tight Binding to HIV-1 Reverse Transcriptase (RT)

Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors.

Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

On the Active Site Protonation State in Aspartic Proteases: Implications for Drug Design ⬇️

P2–P1′ macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis ⬇️

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold.

Peptide-based inhibitors of hepatitis C virus full-length NS3 (protease-helicase/NTPase): model compounds towards small molecule inhibitors.

Probing the Kinetic Mechanism and Coenzyme Specificity of Glutathione Reductase from the CyanobacteriumAnabaenaPCC 7120 by Redesign of the Pyridine-Nucleotide-Binding Site†

Quantification of interactions between drug leads and serum proteins by use of “binding efficiency”

Refolding of the full-length non-structural protein 3 of hepatitis C virus.

Screening for NNRTIs with slow dissociation and high affinity for a panel of HIV-1 RT variants.

Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology.

Sensitivity analysis and error structure of progress curves

Structural Changes of Mercaptohexanol Self-Assembled Monolayers on Gold and Their Influence on Impedimetric Aptamer Sensors

Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors.

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication

Structure–activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V ⬇️

Studies of substrate-induced conformational changes in human cytomegalovirus protease using optical biosensor technology.

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

Synthesis and Comparative Molecular Field Analysis (CoMFA) of Symmetric and Nonsymmetric Cyclic Sulfamide HIV-1 Protease Inhibitors

Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors

Synthesis ofC2Symmetric Potential Inhibitors of HIV-1 Protease From D-Mannitol

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors – characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles