List of works - Markus A Seeliger

A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems.

scientific article published on 8 August 2016

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

scientific article

A conserved protonation-dependent switch controls drug binding in the Abl kinase

scientific article

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

scientific article

A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis.

scientific article published on 31 December 2013

Activation of tyrosine kinases by mutation of the gatekeeper threonine

scientific article

An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression

scientific article published on 26 July 2018

Analysis of DEAD-box proteins in mRNA export

scientific article published in January 2012

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

scientific article

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.

scientific article

Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue † ‡

scientific article

Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity

scientific article

Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.

scientific article published on 29 October 2013

Cooperative organization in a macromolecular complex

scientific article published on 03 August 2003

Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFR , Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants

scientific article

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

scientific article

Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity

scientific article

Enzymatic Activity and Thermodynamic Stability of Biliverdin IXβ Reductase Are Maintained by an Active Site Serine.

scientific article published on 29 November 2016

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

scientific article

Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing

scientific article (publication date: August 2015)

Folding and Association of the Human Cell Cycle Regulatory Proteins ckshs1 and ckshs2†

scientific article published on 01 January 2002

Folding and fibril formation of the cell cycle protein Cks1

scientific article published on 04 May 2006

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

scientific article

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles

scientific article

How does a drug molecule find its target binding site?

scientific article published on 13 May 2011

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

scientific article published on 01 February 2020

KA1 Domains: Unity in Mechanistic Diversity

scientific article published on 01 August 2018

Kinase inhibitors: an allosteric add-on.

scientific article published on 7 September 2014

Measuring Phospholipase D Enzymatic Activity Through Biochemical and Imaging Methods.

scientific article published on 22 October 2016

Mechanism of CDK5/p25 binding by CDK inhibitors

scientific article

Metazoan-like signaling in a unicellular receptor tyrosine kinase.

scientific article

More Diversity Yields a Clearer Picture into the Architecture of the Protein Kinase Domain

scientific article published on 01 October 2018

N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor.

scientific article published on 13 August 2009

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase

scientific article

Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

scientific article published on 21 February 2019

Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins

scientific article (publication date: 26 August 2005)

Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

scientific article

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles

scientific article

Structural and functional analysis of the allosteric inhibition of IRE1α with ATP-competitive ligands

scientific article

Structural basis for the recognition of c-Src by its inactivator Csk

scientific article

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

scientific article published on 13 May 2019

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

scientific article published on 18 December 2017

Targeting conformational plasticity of protein kinases

scientific article published on 19 December 2014

Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions.

scientific article

Three different binding sites of Cks1 are required for p27-ubiquitin ligation

scientific article (publication date: November 2002)

Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes

scientific article

What Makes a Kinase Promiscuous for Inhibitors?

scientific article published on 03 January 2019

c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty

scientific article

List of works by Markus A Seeliger

A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems.

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

A conserved protonation-dependent switch controls drug binding in the Abl kinase

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis.

Activation of tyrosine kinases by mutation of the gatekeeper threonine

An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression

Analysis of DEAD-box proteins in mRNA export

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.

Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue † ‡

Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity

Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.

Cooperative organization in a macromolecular complex

Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFR , Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity

Enzymatic Activity and Thermodynamic Stability of Biliverdin IXβ Reductase Are Maintained by an Active Site Serine.

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing

Folding and Association of the Human Cell Cycle Regulatory Proteins ckshs1 and ckshs2†

Folding and fibril formation of the cell cycle protein Cks1

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles

How does a drug molecule find its target binding site?

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

KA1 Domains: Unity in Mechanistic Diversity

Kinase inhibitors: an allosteric add-on.

Measuring Phospholipase D Enzymatic Activity Through Biochemical and Imaging Methods.

Mechanism of CDK5/p25 binding by CDK inhibitors

Metazoan-like signaling in a unicellular receptor tyrosine kinase.

More Diversity Yields a Clearer Picture into the Architecture of the Protein Kinase Domain

N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor.

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase

Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins

Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles

Structural and functional analysis of the allosteric inhibition of IRE1α with ATP-competitive ligands

Structural basis for the recognition of c-Src by its inactivator Csk

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Targeting conformational plasticity of protein kinases

Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions.

Three different binding sites of Cks1 are required for p27-ubiquitin ligation

Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes

What Makes a Kinase Promiscuous for Inhibitors?

c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty