List of works - Sylvia Adams

A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer

scientific article

Abstract P2-11-11: Phase II trial of exemestane with immunomodulatory oral cyclophosphamide in metastatic hormone receptor (HR)-positive breast cancer: Prolonged progression-free survival (PFS) in patients with distinct T regulatory cell (Treg) profi

Antibody-drug conjugates in triple negative breast cancer

scientific article published on 03 September 2018

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Ca

scientific article published on 2 August 2017

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in I

scientific article published in September 2017

Atezolizumab Plus nab-Paclitaxel in the Treatment of Metastatic Triple-Negative Breast Cancer With 2-Year Survival Follow-up: A Phase 1b Clinical Trial

scientific article published on 01 March 2019

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial

scientific article published on 27 November 2019

CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three cases

scientific article published on 5 April 2011

Checkpoint inhibitors in triple-negative breast cancer (TNBC): Where to go from here

scientific article published on 9 February 2018

Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology

scientific article published on 10 December 2013

Clinical Trial Evidence of the Antitumor Activity of Topical Imiquimod for Breast Cancer Skin Metastases

scientific article published on 04 August 2014

Clinical cancer advances 2010: annual report on progress against cancer from the American Society of Clinical Oncology

scientific article

Clinical cancer advances 2011: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology

scientific article published on 5 December 2011

Clinical cancer advances 2012: annual report on progress against cancer from the american society of clinical oncology

scientific article published on 3 December 2012

Current Landscape of Immunotherapy in Breast Cancer: A Review

scientific article published on 11 April 2019

Distinct breast cancer subtypes in women with early-onset disease across races

scientific article

Dramatic response of metaplastic breast cancer to chemo-immunotherapy

scientific article published on 29 March 2017

Efficacy of RAD001/carboplatin in triple-negative metastatic breast cancer: A phase II study

Enlisting the Immune System to Cure Breast Cancer--A Recipe for Success.

scientific article

Expression of cancer testis antigens in human BRCA-associated breast cancers: potential targets for immunoprevention?

scientific article published on 05 April 2011

Expression of the cancer/testis antigen NY-ESO-1 in primary and metastatic malignant melanoma (MM)--correlation with prognostic factors

scientific article

Focal Irradiation And Systemic Transforming Growth Factor β Blockade in Metastatic Breast Cancer

scientific article published on 23 February 2018

Giant acquired reactive perforating collagenosis in a patient with diabetes mellitus and metastatic breast carcinoma

scientific article published on 14 January 2016

If we build it they will come: targeting the immune response to breast cancer

scientific article published on 29 October 2019

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

scientific article

Immune-checkpoint inhibition for metastatic triple-negative breast cancer: safety first?

scientific article published on 01 July 2019

Inhibition of Breast Cancer Metastasis by Presurgical Treatment with an Oral Matrix Metalloproteinase Inhibitor: A Preclinical Proof-of-Principle Study.

scientific article published on 27 July 2016

Lack of Functionally Active Melan-A26–35-Specific T Cells in the Blood of HLA-A2+ Vitiligo Patients

scientific article published on 13 March 2008

Lack of Robust Prognostic Biomarkers for Immunotherapy in Breast Cancer-Adverse Events-In Reply

scientific article published on 12 September 2019

Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial.

scientific article published on 18 June 2015

Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer

scientific article published in 2013

MAGE-specific T cells detected directly ex-vivo correlate with complete remission in metastatic breast cancer patients after sequential immune-endocrine therapy.

scientific article published on 16 September 2014

Manipulating dendritic cell biology for the active immunotherapy of cancer

scientific article published in July 2004

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

article published in 2018

Maturation Matters: Importance of Maturation for Antitumor Immunity of Dendritic Cell Vaccines

scientific article published on 01 September 2004

Metaplastic breast cancers: Genomic profiling, mutational burden and tumor-infiltrating lymphocytes

scientific article published on 20 December 2018

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

scientific article published on 22 November 2017

Nab-paclitaxel-induced cystoid macular edema in a patient with pre-existing optic neuropathy

scientific article

Novel therapeutic agents under investigation for malignant melanoma

scientific article

Patient-reported outcomes from the phase III IMpassion130 trial of atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer

scientific article published on 20 February 2020

Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study

scientific article published on 01 March 2019

Pembrolizumab monotherapy for previously untreated, PD-L1-positive, metastatic triple-negative breast cancer: cohort B of the phase II KEYNOTE-086 study

scientific article published on 01 March 2019

Phase 2 trial of everolimus and carboplatin combination in patients with triple negative metastatic breast cancer

scientific article

Phase II trial of RAD001 plus carboplatin in patients with triple-negative metastatic breast cancer

Post-mastectomy Radiation Therapy in Breast Cancer Patients with Nodal Micrometastases

scientific article published on 09 July 2018

Predictive Biomarkers for Checkpoint Immunotherapy: Current Status and Challenges for Clinical Application

scientific article published on 01 October 2018

Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival

scientific article published on 29 September 2010

Primary large cell neuroendocrine carcinoma of the breast, a case report with an unusual clinical course.

scientific article published on 30 March 2015

Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in Breast Cancer

Prognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden in triple negative breast cancer patients after neo-adjuvant chemotherapy

scientific article published on 01 February 2019

Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.

scientific article

Recent advances in dendritic cell biology

scientific article

Recent advances in dendritic cell biology

scientific article published on 01 May 2005

Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma

scientific article

Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning

scholarly article by F Klauschen et al published October 2018 in Seminars in Cancer Biology

Serial immunological parameters in a phase II trial of exemestane and low-dose oral cyclophosphamide in advanced hormone receptor-positive breast cancer

scientific article published on 9 November 2017

Small-molecule protein kinase inhibitors and their effects on the immune system: implications for cancer treatment

scientific article published on February 2011

Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer

scientific article

Targeting Toll-Like Receptors for Cancer Therapy

scientific article published on 01 October 2018

The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer

scientific article published on 22 April 2016

The TLR7 agonist imiquimod as an adjuvant for radiotherapy-elicited in situ vaccination against breast cancer

scientific article published on 24 September 2013

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.

scientific article published on 11 September 2014

The numbers of FoxP3+ lymphocytes in sentinel lymph nodes of breast cancer patients correlate with primary tumor size but not nodal status

scientific article published on July 2011

The path to a better biomarker: Application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice

scientific article published on 04 March 2020

Therapeutic landscape of metaplastic breast cancer

scientific article published on 13 August 2019

Toll-like receptor agonists in cancer therapy

scientific article

Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer

scientific article published on 5 July 2012

Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod

scientific article published on 12 June 2019

Tumor infiltrating lymphocytes (TILs) improve prognosis in patients with triple negative breast cancer (TNBC).

scientific article

Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers

scientific article published on 16 January 2019

Tumor-Infiltrating Lymphocytes in a Contemporary Cohort of Women with Ductal Carcinoma In Situ (DCIS)

scientific article published on 25 June 2019

Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer

scientific article published on 08 October 2019

Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells

scientific article published in November 2008

Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group o

article by Maria Vittoria Dieci et al published October 2018 in Seminars in Cancer Biology

Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.

scholarly article

Variation in the Incidence and Magnitude of Tumor-Infiltrating Lymphocytes in Breast Cancer Subtypes: A Systematic Review

scientific article

Voxelwise analysis of simultaneously acquired and spatially correlated 18 F-fluorodeoxyglucose (FDG)-PET and intravoxel incoherent motion metrics in breast cancer.

scientific article

List of works by Sylvia Adams

A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer

Abstract P2-11-11: Phase II trial of exemestane with immunomodulatory oral cyclophosphamide in metastatic hormone receptor (HR)-positive breast cancer: Prolonged progression-free survival (PFS) in patients with distinct T regulatory cell (Treg) profi

Antibody-drug conjugates in triple negative breast cancer

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Ca

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in I

Atezolizumab Plus nab-Paclitaxel in the Treatment of Metastatic Triple-Negative Breast Cancer With 2-Year Survival Follow-up: A Phase 1b Clinical Trial

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial

CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three cases

Checkpoint inhibitors in triple-negative breast cancer (TNBC): Where to go from here

Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology

Clinical Trial Evidence of the Antitumor Activity of Topical Imiquimod for Breast Cancer Skin Metastases

Clinical cancer advances 2010: annual report on progress against cancer from the American Society of Clinical Oncology

Clinical cancer advances 2011: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology

Clinical cancer advances 2012: annual report on progress against cancer from the american society of clinical oncology

Current Landscape of Immunotherapy in Breast Cancer: A Review

Distinct breast cancer subtypes in women with early-onset disease across races

Dramatic response of metaplastic breast cancer to chemo-immunotherapy

Efficacy of RAD001/carboplatin in triple-negative metastatic breast cancer: A phase II study

Enlisting the Immune System to Cure Breast Cancer--A Recipe for Success.

Expression of cancer testis antigens in human BRCA-associated breast cancers: potential targets for immunoprevention?

Expression of the cancer/testis antigen NY-ESO-1 in primary and metastatic malignant melanoma (MM)--correlation with prognostic factors

Focal Irradiation And Systemic Transforming Growth Factor β Blockade in Metastatic Breast Cancer

Giant acquired reactive perforating collagenosis in a patient with diabetes mellitus and metastatic breast carcinoma

If we build it they will come: targeting the immune response to breast cancer

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

Immune-checkpoint inhibition for metastatic triple-negative breast cancer: safety first?

Inhibition of Breast Cancer Metastasis by Presurgical Treatment with an Oral Matrix Metalloproteinase Inhibitor: A Preclinical Proof-of-Principle Study.

Lack of Functionally Active Melan-A26–35-Specific T Cells in the Blood of HLA-A2+ Vitiligo Patients

Lack of Robust Prognostic Biomarkers for Immunotherapy in Breast Cancer-Adverse Events-In Reply

Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial.

Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer

MAGE-specific T cells detected directly ex-vivo correlate with complete remission in metastatic breast cancer patients after sequential immune-endocrine therapy.

Manipulating dendritic cell biology for the active immunotherapy of cancer

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

Maturation Matters: Importance of Maturation for Antitumor Immunity of Dendritic Cell Vaccines

Metaplastic breast cancers: Genomic profiling, mutational burden and tumor-infiltrating lymphocytes

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Nab-paclitaxel-induced cystoid macular edema in a patient with pre-existing optic neuropathy

Novel therapeutic agents under investigation for malignant melanoma

Patient-reported outcomes from the phase III IMpassion130 trial of atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer

Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study

Pembrolizumab monotherapy for previously untreated, PD-L1-positive, metastatic triple-negative breast cancer: cohort B of the phase II KEYNOTE-086 study

Phase 2 trial of everolimus and carboplatin combination in patients with triple negative metastatic breast cancer

Phase II trial of RAD001 plus carboplatin in patients with triple-negative metastatic breast cancer

Post-mastectomy Radiation Therapy in Breast Cancer Patients with Nodal Micrometastases

Predictive Biomarkers for Checkpoint Immunotherapy: Current Status and Challenges for Clinical Application

Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival

Primary large cell neuroendocrine carcinoma of the breast, a case report with an unusual clinical course.

Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in Breast Cancer

Prognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden in triple negative breast cancer patients after neo-adjuvant chemotherapy

Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.

Recent advances in dendritic cell biology

Recent advances in dendritic cell biology

Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma

Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning

Serial immunological parameters in a phase II trial of exemestane and low-dose oral cyclophosphamide in advanced hormone receptor-positive breast cancer

Small-molecule protein kinase inhibitors and their effects on the immune system: implications for cancer treatment

Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer

Targeting Toll-Like Receptors for Cancer Therapy

The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer

The TLR7 agonist imiquimod as an adjuvant for radiotherapy-elicited in situ vaccination against breast cancer

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.

The numbers of FoxP3+ lymphocytes in sentinel lymph nodes of breast cancer patients correlate with primary tumor size but not nodal status

The path to a better biomarker: Application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice

Therapeutic landscape of metaplastic breast cancer

Toll-like receptor agonists in cancer therapy

Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer

Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod

Tumor infiltrating lymphocytes (TILs) improve prognosis in patients with triple negative breast cancer (TNBC).

Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers

Tumor-Infiltrating Lymphocytes in a Contemporary Cohort of Women with Ductal Carcinoma In Situ (DCIS)

Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer

Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells

Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group o

Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.

Variation in the Incidence and Magnitude of Tumor-Infiltrating Lymphocytes in Breast Cancer Subtypes: A Systematic Review

Voxelwise analysis of simultaneously acquired and spatially correlated 18 F-fluorodeoxyglucose (FDG)-PET and intravoxel incoherent motion metrics in breast cancer.