List of works by Pamela Ohashi

14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.

scientific article

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts: National Harbor, MD, USA. 9-13 November 2016.

scientific article published on 8 December 2016

A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation

scientific article published in Science

A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

scientific article published on 21 January 2020

A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology

scientific article

A cortisone sensitive CD3low subset of CD4+CD8- thymocytes represents an intermediate stage in intrathymic repertoire selection

scientific article published on February 1, 1992

A distinct innate lymphoid cell population regulates tumor-associated T cells

scientific article published on 6 February 2017

A regulatory role for TRAF1 in antigen-induced apoptosis of T cells.

scientific article published on May 1997

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

scientific journal article

Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration.

scientific article published in April 1998

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

scientific article (publication date: 18 November 1999)

Activation of Peroxisome Proliferator-Activated Receptors α and δ Synergizes with Inflammatory Signals to Enhance Adoptive Cell Therapy

scientific article published on 20 December 2018

Activation of cytotoxic T cells by solid tumours?

scientific article published on March 1998

Acute graft-versus-host disease without costimulation via CD28

scientific article published on 01 April 1997

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

scientific article published on 26 April 2009

Aggravation of viral hepatitis by platelet-derived serotonin

scientific article published on 30 May 2008

Alloreactive cytotoxic T cells recognize minor transplantation antigens presented by major histocompatibility complex class Ib molecules

scientific article published on 01 September 1998

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

scientific article

Antigens expressed by myelinating glia cells induce peripheral cross-tolerance of endogenous CD8+ T cells.

scientific article

Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive.

scientific article

Autoimmunity

scientific article published on 01 December 2003

B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

scientific article

B7-H4 is a positive regulator of antitumor immunity

scientific article published on June 2015

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

scientific article

CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.

scientific article

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

scientific article

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

scholarly article

Cancer classification using the Immunoscore: a worldwide task force

scientific article

Caspase 3 is not essential for the induction of anergy or multiple pathways of CD8+ T-cell death

scientific article published on 01 December 2010

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

scientific article published on May 2005

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

scientific journal article

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

scientific article

Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch

scientific article published on 12 July 2013

Central tolerance: what you see is what you don't get!

scientific article published on 01 February 2016

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

scientific article

Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study

scientific article published in 2022

Clinical blockade of PD1 and LAG3--potential mechanisms of action

scientific article published on January 2015

Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny

scientific article published on May 1992

Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses

scientific article published on 29 June 2003

Costimulation, a surprising connection for immunotherapy.

scientific article published in March 2017

DNA damage- and stress-induced apoptosis occurs independently of PIDD

scientific article published on 01 September 2009

Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation

scientific article

Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection

scientific article

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth.

scientific article published on 22 September 2009

Development of autoreactive diabetogenic T cells in the thymus of NOD mice

scientific article published on 08 December 2004

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

scientific article

Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity

scientific article

Differential Control of CD28-Regulated In Vivo Immunity by the E3 Ligase Cbl-b

scientific article published on 01 February 2005

Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines

scientific article

Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo

scientific article

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation

scientific article published on 01 October 1997

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

scientific article published on 01 November 2001

Duration of TCR stimulation determines costimulatory requirement of T cells

scientific article published on 01 July 1996

Dysregulation of immune homeostasis in autoimmune diseases

scientific article published on 06 January 2012

Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection.

scientific article published on February 1993

Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels

scientific article published on 01 October 1994

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

scientific article

Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling

scientific article published on 09 January 2007

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

scientific article published in August 2004

Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice

scientific article

Evidence for a selective and multi-step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules

scientific article published on 01 September 1994

Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs)

scientific article published on 10 November 2010

Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes

scientific article

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

scientific article published on 01 July 2001

Expression of CD4 can confer major histocompatibility complex class II-associated superantigen reactivity upon a T cell receptor derived from a CD8-dependent cytotoxic T lymphocyte clone

scientific article published on 01 November 1990

Fighting cancers from within: augmenting tumor immunity with cytokine therapy

scientific article published on 17 June 2010

Four types of Ca2+ signals in naive CD8+ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists

scientific article published on 01 December 1997

GSK3: an in-Toll-erant protein kinase?

Generation and characterization of B7-H4/B7S1/B7x-deficient mice

scientific journal article

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

scientific article published on 6 November 2017

Hematopoietic cell-derived interferon controls viral replication and virus-induced disease

scientific article published on 29 October 2008

High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation

scientific article published on 31 December 2019

Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

scientific article published on 16 November 2003

Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.

scientific article

Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity

scientific article published on 31 December 2020

ICOS is essential for effective T-helper-cell responses

scientific journal article

IL-1 Receptor-Associated Kinase 4 Is Essential for IL-18-Mediated NK and Th1 Cell Responses

article

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

scientific article published on 03 February 2011

IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function

scientific article published on 21 January 2020

IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.

scientific article published in March 2008

IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.

scientific article

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

scientific article

Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function.

scientific article published on September 1999

Immunological perspective of self versus tumor antigens: insights from the RIP-gp model.

scientific article published on May 2011

Immunology. Exposing thy self

scientific article published on 01 November 2002

Immunoregulatory functions of innate lymphoid cells

scientific article published on 19 November 2018

Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

scientific article published in September 1997

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

article

In vivo generation of cytotoxic T cells from epitopes displayed on peptide-based delivery vehicles.

scientific article

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

scientific article published in The Lancet

Intricate connections between innate and adaptive autoimmunity

scientific article published on 01 December 2007

K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.

scientific article published on 13 January 2017

Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection

scientific article published on 19 December 2011

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

scientific article

Making and breaking tolerance.

scientific article

Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity

scientific article published on 28 October 2019

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

scientific journal article

Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges.

scientific article published on 28 December 2012

Mir-155, a central modulator of T-cell responses.

scientific article published on January 2014

Mobilizing and evaluating anticancer T cells: pitfalls and solutions.

scientific article published on 16 October 2013

Modulating autoimmunity: pick your PI3 kinase

scientific article published in September 2005

Molecular Pathways: Evaluating the Potential for B7-H4 as an Immunoregulatory Target

scientific article published on 21 March 2017

Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance.

scientific article published on May 2013

Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician.

scientific article published on 10 April 2017

Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer

scientific article published on 08 September 2020

Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition

publication published on 09 February 2021

Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

scientific article published on 13 December 2011

Natural killer cells regulate diverse T cell responses.

scientific article published on 17 April 2013

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

scientific article published in Nature

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

scientific article

Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice

scholarly article by Paul Waterhouse et al published August 1997 in European Journal of Immunology

Notch Shapes the Innate Immunophenotype in Breast Cancer

scientific article

Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells

scientific article published on 13 November 2011

ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.

scientific article

Oxidized ATP inhibits T-cell-mediated autoimmunity.

scientific article published on September 2010

Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development

article

Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

scientific article published on 01 September 1997

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

scientific article published in May 1997

Peptide-pulsed dendritic cells have superior ability to induce immune-mediated tissue destruction compared to peptide with adjuvant

scientific article

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

scientific article published in Science

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

scientific article

Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer

scientific article published on 11 February 2020

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

scientific article published on 8 September 2016

RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses

scientific article published in January 2008

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

scientific article published on September 1994

Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency

scientific article

Regulation of T cell activation, anxiety, and male aggression by RGS2.

scientific article

Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens

scientific article

Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

scientific article published on 31 July 2018

Reorganization of unique and repetitive sequences during nuclear development in Tetrahymena thermophila.

scientific article published on September 1982

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

scientific article published on 01 January 1997

Requirement of the IL-2 receptor beta chain for the development of Vgamma3 dendritic epidermal T cells.

scientific article published in June 1998

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development.

scientific article published on 13 June 2010

Selection of the T cell repertoire.

scientific article

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy ⬇️

scientific article published on August 29, 1997

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

scientific article (publication date: 18 April 2002)

Shp1 regulates T cell homeostasis by limiting IL-4 signals

scientific article published on July 2013

Skin allograft rejection in CD28-deficient mice

scientific article published on 01 February 1996

Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule

scientific article published on 21 June 2016

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

scientific journal article

Supressing the supressors

scientific article published on 01 September 2006

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

scientific article published on 01 May 2001

T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population

scientific article published on 01 February 1990

T cell responses are governed by avidity and co-stimulatory thresholds

scientific article published on 01 September 1996

T cells causing immunological disease

scientific article published on January 1, 1992

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

article

TCR affinity and negative regulation limit autoimmunity

article

TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR

scientific article published on 01 September 2003

TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice

scientific article

TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.

scientific article published in September 1999

Targeting of pancreatic glia in type 1 diabetes.

scientific article published on 15 January 2008

The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation

scientific article published on 18 July 2012

The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.

scientific article published on 2 January 2012

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

scientific article published on November 2012

The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation

scientific article published on 10 January 2011

The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo.

scientific article published on July 2002

The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.

scientific article published in May 2004

The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes

scientific article published on 01 November 1993

The role of T-cell receptor dimerization in T-cell activation.

scientific article

The sound of silence: modulating anergy in T lymphocytes.

scientific article

Thymic ontogeny and selection of alpha beta and gamma delta T cells

scientific article published on 01 December 1989

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

scientific article published on 26 September 2014

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

scientific article

Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage

scientific article

Transgenic mice as an in vivo model for self-reactivity.

scientific article published on December 1990

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytesin vivo

scientific article published on 01 December 1996

Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

scientific article published on 5 June 2014

Vaccination or tolerance to prevent diabetes

scientific article published on 01 December 1992

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

scientific article published in March 2002

Weak agonist self-peptides promote selection and tuning of virus-specific T cells

scientific article published in March 2003

Zeroing in on Tumor-Reactive TILs.

scientific article published in September 2016

c-Rel but not NF-κB1 is important for T regulatory cell development

scientific article published on 01 March 2010

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

scientific article

miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1.

scientific article published on 7 October 2015

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