List of works - Michael J Courtney

A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs.

scientific article

ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function

scientific article published on 3 February 2016

All JNKs Can Kill, but Nuclear Localization Is Critical for Neuronal Death

scientific article published in Journal of Biological Chemistry

Alpha2B-adrenoceptors couple to Ca2+ increase in both endogenous and recombinant expression systems.

scientific article published on December 1998

Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells.

scientific article published in May 1997

Ca2+-dependent potentiation of muscarinic receptor-mediated Ca2+ elevation

scientific article

Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

scientific article published on February 2012

Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells

scientific article published in June 2009

Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector

scientific journal article

Coupling of astroglial alpha 2-adrenoreceptors to second messenger pathways

scientific article published on 01 June 1996

Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors.

scientific article

Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice

scientific article published on 9 January 2018

Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death

scientific article

Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

scientific article published in October 2000

Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element

scientific article published on 15 March 2017

Establishing an effective dose for chronic intracerebroventricular administration of clozapine in mice

scientific article published on 19 August 2019

Ethanol Specifically Inhibits NMDA Receptors with Affinity for Ifenprodil in the Low Micromolar Range in Cultured Cerebellar Granule Cells ⬇️

scientific article published on November 1, 1997

Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis.

scientific article published on October 2003

Hippocampal long-term depression is enhanced, depotentiation is inhibited and long-term potentiation is unaffected by the application of a selective c-Jun N-terminal kinase inhibitor to freely behaving rats.

scientific article published on 31 March 2011

Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models

scientific article published on 2 May 2016

Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: protein kinase C mediated inhibition of N-methyl-D-aspartate responses

scientific article published on September 1, 1992

Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3.

scientific article published on September 2003

Localization of voltage-sensitive Ca2+ fluxes and neuropeptide Y immunoreactivity to varicosities in SH-SY5Y human neuroblastoma cells differentiated by treatment with the protein kinase inhibitor staurosporine.

scientific article published on January 1997

Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling

scientific article published on 27 August 2014

Metabotropic receptor-mediated regulation of cytoplasmic free calcium in cultured cerebellar granule cells.

scientific article published in April 1991

Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway

scientific article published on 27 January 2014

Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism

scientific article published on June 1997

Rapid Ca 2+ Mobilization in Single LGL Cells upon Interaction with K562 Target Cells--Role of the CD18 and CD16 Molecules

scientific article published on 01 October 1995

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation

scientific article published on 3 June 2008

Redox-Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death.

scientific article published on 22 December 2016

Regulation of SAPKs in CNS neurons.

scientific article published in November 1997

Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators

scientific article published on 09 October 2020

Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death

scientific journal article

Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields

Superior cervical ganglion-10 protein as a molecular effector of c-Jun N-terminal kinase 1: implications for the therapeutic targeting of Jun N-terminal kinase in nerve regeneration

scientific article published on January 2008

The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death

scientific article published on January 2005

The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death

scientific article published on 14 January 2008

The calcium response to the excitotoxin kainate is amplified by subsequent reduction of extracellular sodium

scientific article published on 01 October 1995

The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells

scientific article published in December 1990

The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death

scientific journal article

The role of topoisomerase II in the excision of DNA loop domains during apoptosis

scientific article published on 8 April 2002

Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models.

scientific article

ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability

scholarly article published in Molecular Pain

c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells

scientific article

c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.

scientific article published in June 2002

List of works by Michael J Courtney

A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs.

ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function

All JNKs Can Kill, but Nuclear Localization Is Critical for Neuronal Death

Alpha2B-adrenoceptors couple to Ca2+ increase in both endogenous and recombinant expression systems.

Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells.

Ca2+-dependent potentiation of muscarinic receptor-mediated Ca2+ elevation

Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells

Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector

Coupling of astroglial alpha 2-adrenoreceptors to second messenger pathways

Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors.

Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice

Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death

Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element

Establishing an effective dose for chronic intracerebroventricular administration of clozapine in mice

Ethanol Specifically Inhibits NMDA Receptors with Affinity for Ifenprodil in the Low Micromolar Range in Cultured Cerebellar Granule Cells ⬇️

Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis.

Hippocampal long-term depression is enhanced, depotentiation is inhibited and long-term potentiation is unaffected by the application of a selective c-Jun N-terminal kinase inhibitor to freely behaving rats.

Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models

Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: protein kinase C mediated inhibition of N-methyl-D-aspartate responses

Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3.

Localization of voltage-sensitive Ca2+ fluxes and neuropeptide Y immunoreactivity to varicosities in SH-SY5Y human neuroblastoma cells differentiated by treatment with the protein kinase inhibitor staurosporine.

Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling

Metabotropic receptor-mediated regulation of cytoplasmic free calcium in cultured cerebellar granule cells.

Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway

Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism

Rapid Ca 2+ Mobilization in Single LGL Cells upon Interaction with K562 Target Cells--Role of the CD18 and CD16 Molecules

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation

Redox-Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death.

Regulation of SAPKs in CNS neurons.

Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators

Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death

Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields

Superior cervical ganglion-10 protein as a molecular effector of c-Jun N-terminal kinase 1: implications for the therapeutic targeting of Jun N-terminal kinase in nerve regeneration

The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death

The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death

The calcium response to the excitotoxin kainate is amplified by subsequent reduction of extracellular sodium

The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells

The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death

The role of topoisomerase II in the excision of DNA loop domains during apoptosis

Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models.

ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability

c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells

c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.