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List of works by Taha Merghoub

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A Retrospective Evaluation of Vemurafenib as Treatment for BRAF-Mutant Melanoma Brain Metastases.

scientific article published on 8 May 2015

Abstract 2711: Rational combination of GITR agonism with PD-1 blockade

scholarly article

Abstract 3735: An anti-tumor immune response is evoked by partial-volume single dose radiation

scholarly article

Abstract 4843: TP53-stabilization with APR-246 enhances antitumor effects of immune checkpoint blockade in preclinical models

scholarly article

Abstract 978: Tim-4+ tissue-resident macrophages impair antitumor T-cell immunity

scholarly article

Abstract LB-081: A nuclear cAMP microdomain functions as a tumor suppressor in melanoma

scholarly article

Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity

scientific article

Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation

scientific article

Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity ⬇️

scientific article (publication date: 10 September 2010)

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer

scientific article published on 7 October 2015

An Anti-Tumor Immune Response is Evoked By Partial-Volume Single Dose Radiation in Two Murine Models

scientific article published on 18 October 2018

Atypical t(15;17)(q13;q12) in a patient with all-trans retinoic acid refractory secondary acute promyelocytic leukemia: a case report and review of the literature

scientific article

Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

scientific article published on 01 November 2019

Blockade of Treg derived TGF-β abrogates suppression of effector T cell function within the tumor microenvironment

scientific article published on 7 November 2013

Blockade of surface bound TGF-β abrogates Treg suppression of effector T cell function within the tumor microenvironment.

scientific article published on 6 November 2014

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

scientific article

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

scientific article published on 11 August 2020

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

scientific article published on 17 February 2020

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

scientific article (publication date: 3 April 2015)

Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion

scientific article published on January 2016

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

scientific article published on 03 March 2016

Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates.

scientific article published on 26 February 2014

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

scientific article published on 01 March 2020

Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis.

scientific article

Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs

scientific article

Detection of intra-tumor self antigen recognition during melanoma tumor progression in mice using advanced multimode confocal/two photon microscope

scientific article (publication date: 2011)

Development of effective vaccines for old mice in a tumor model

scientific article

Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis

scientific journal article

EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors

scientific article

Enhanced responses to tumor immunization following total body irradiation are time-dependent

scientific article

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

scientific article published on 30 July 2020

GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability

scientific article

Genetic basis for clinical response to CTLA-4 blockade in melanoma

scientific article (publication date: 4 December 2014)

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

scientific article

Immunotherapy and the belly of the beast

scientific article

Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non-Small Cell Lung Cancer

scientific article published on 08 July 2021

Impairment of Treg suppression by GITR ligation is effective selectively in the context of a pro-inflammatory tumor microenvironment.

scientific article published on 6 November 2014

Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma

scientific article published on December 2008

In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors

scientific article published on 22 July 2019

In vitro assays for effector T cell functions and activity of immunomodulatory antibodies

scientific article published on 22 October 2019

In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response

scientific article published in 2022

Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype

scientific article

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

scientific article

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

scientific article published on 25 February 2016

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

scientific article published on 01 April 2017

Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain

scientific article

Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells

scientific article published on May 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity

scientific article published on 13 February 2017

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

scientific article published on 02 October 2020

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells.

scientific article published on 28 September 2016

LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis

scientific article published on October 2009

Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy

scientific article

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

scientific article

Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal

scientific article

Mechanisms of immunization against cancer using chimeric antigens

scientific article

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

scientific article

Metastasis and immune evasion from extracellular cGAMP hydrolysis

scientific article published on 28 December 2020

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway

scientific article

Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment

scientific article published on 15 December 2011

Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia

scientific article published on 20 November 2003

Myeloid-derived suppressor sells and the efficacy of CD8(+) T-cell immunotherapy

scientific article published on February 2013

Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway

scientific article

Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma

scientific article published on 11 April 2022

Neutrophil phenotypes and functions in cancer: A consensus statement

scientific article published in 2022

Non-conventional Inhibitory CD4Foxp3PD-1 T Cells as a Biomarker of Immune Checkpoint Blockade Activity

scientific article published on 01 June 2018

Non-conventional Inhibitory CD4Foxp3PD-1 T Cells as a Biomarker of Immune Checkpoint Blockade Activity

scientific article published on 01 October 2018

OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.

scientific article published on 04 May 2009

One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade.

scientific article published in June 2019

Optimization of a self antigen for presentation of multiple epitopes in cancer immunity

scientific article

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.

scientific article published on 9 November 2016

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

scientific article published on 29 July 2019

POKEMON Is a Proto-Oncogene Which Plays a Key Role in Lymphomagenesis. ⬇️

scholarly article

Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor

scientific article published on January 2014

Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling

scientific article (publication date: October 2002)

Rational design of anti-GITR-based combination immunotherapy

scientific article published on 29 April 2019

Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

scientific article published on May 2007

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas ⬇️

scientific article published on November 13, 2012

Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

scientific article

Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.

scientific article published on 30 March 2009

Systemic Antitumor Immunity by PD-1/PD-L1 Inhibition Is Potentiated by Vascular-Targeted Photodynamic Therapy of Primary Tumors

scientific article published on 27 September 2017

Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma

scientific article published on 01 January 2021

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors

scientific article published on 13 February 2016

The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy.

scientific article published on 09 June 2015

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease

scientific article

The importance of animal models in tumor immunity and immunotherapy

scientific article

Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.

scientific article published on 25 April 2016

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

scientific article

Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3.

scientific article published on 20 August 2008

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