List of works - Giorgio Cozza

8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment.

scientific article

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

scientific article

A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins.

scientific article published on 30 April 2015

A novel glucosyltransferase from Catharanthus roseus cell suspensions

scientific article published in 2010

A novel splicing variant encoding putative catalytic alpha subunit of maize protein kinase CK2.

scientific article published on 22 May 2009

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

scientific article published on 29 November 2018

ALK kinase domain mutations in primary anaplastic large cell lymphoma: consequences on NPM-ALK activity and sensitivity to tyrosine kinase inhibitors

scientific article

ATP non-competitive Ser/Thr kinase inhibitors as potential anticancer agents

scientific article published on September 2009

Autophosphorylation at the regulatory beta subunit reflects the supramolecular organization of protein kinase CK2.

scientific article

Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach

scientific article published on 10 July 2019

Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin

scientific article published on 29 October 2019

Casein hydrolysate for uterine infection treatment: a patent evaluation (WO2011132191) ⬇️

scientific article published on March 29, 2012

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization

scientific article

Casein kinases as potential therapeutic targets

scientific article

Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential

scientific article

Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects

scientific article published on 29 April 2015

Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships

scientific article

Covalently bound DNA on naked iron oxide nanoparticles: Intelligent colloidal nano-vector for cell transfection.

scientific article published in August 2017

Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2.

scientific article

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.

scientific article

Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation

scientific article

Development of a yeast-based system to identify new hBRAFV600E functional interactors

scientific article published on 20 September 2018

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

scientific article published on 11 September 2018

Elucidation of the ribonuclease a aggregation process mediated by 3D domain swapping: A computational approach reveals possible new multimeric structures

article by Giorgio Cozza et al published January 2008 in Biopolymers

Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases

scientific article

Fam20C is under the control of sphingolipid signaling in human cell lines

scientific article published on 25 February 2017

Glutathione Peroxidase 4

scientific article published in 2016

Glutathione Peroxidase-4

scientific article published in 2011

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center.

scientific article published on 11 July 2017

How druggable is protein kinase CK2?

scientific article published on May 2010

Hydrophobic Derivatives of Glycopeptide Antibiotics as Inhibitors of Protein Kinases

scientific article published on 01 October 2018

Identification of Ellagic Acid as Potent Inhibitor of Protein Kinase CK2: A Successful Example of a Virtual Screening Application

Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening

scientific article

Inactivation of the glutathione peroxidase GPx4 by the ferroptosis-inducing molecule RSL3 requires the adaptor protein 14-3-3ε

scientific article published on 20 October 2019

Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study

scientific article

Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight

scientific article

Isoform specific phosphorylation of p53 by protein kinase CK1.

scientific article published on 30 December 2009

Kinase CK2 inhibition: an update.

scientific article published on January 2013

Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery

scientific article

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases

scientific article published on 01 October 2013

Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression

scientific article published in Scientific Reports

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

scientific article published on 27 February 2013

Protein kinase CK2 inhibitors: a patent review

scientific article published on September 2012

Pyrazoloquinazoline Tricyclic System as Novel Scaffold to Design New Kinase CK2 Inhibitors

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

scientific article

Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.

scientific article

Stealth Iron Oxide Nanoparticles for Organotropic Drug Targeting

scientific article published on 12 February 2019

Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A

scientific article

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

scientific article

TG2 regulates the heat-shock response by the post-translational modification of HSF1

scientific article published on 11 May 2018

Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors

scholarly article by Mario A Pagano published in January 2007

Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.

scientific article published on 27 August 2009

The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design

scientific article

The Golgi "casein kinase" Fam20C is a genuine "phosvitin kinase" and phosphorylates polyserine stretches devoid of the canonical consensus

scientific article published on 20 November 2018

The Regulatory β Subunit of Protein Kinase CK2 Contributes to the Recognition of the Substrate Consensus Sequence. A Study with an eIF2β-Derived Peptide†

scientific article published in 2008

The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation

scientific article

The acidophilic kinases PLK2 and PLK3: structure, substrate targeting and inhibition.

scientific article

The dark side of protein kinase CK2 inhibition

scientific article published on January 2011

The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131.

scientific article

The landscape of BRAF transcript and protein variants in human cancer.

scientific article

The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.

scientific article published on 31 January 2014

The role of the N-terminal domain in the regulation of the "constitutively active" conformation of protein kinase CK2α: insight from a molecular dynamics investigation

scientific article published on 17 May 2011

The selectivity of inhibitors of protein kinase CK2: an update

scientific article

Tools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases

scientific article published on April 2012

Understanding mammalian glutathione peroxidase 7 in the light of its homologs.

scientific article published on 25 February 2015

Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer

scientific article

Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors

scientific article published on 4 October 2011

List of works by Giorgio Cozza

8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment.

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins.

A novel glucosyltransferase from Catharanthus roseus cell suspensions

A novel splicing variant encoding putative catalytic alpha subunit of maize protein kinase CK2.

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

ALK kinase domain mutations in primary anaplastic large cell lymphoma: consequences on NPM-ALK activity and sensitivity to tyrosine kinase inhibitors

ATP non-competitive Ser/Thr kinase inhibitors as potential anticancer agents

Autophosphorylation at the regulatory beta subunit reflects the supramolecular organization of protein kinase CK2.

Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach

Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin

Casein hydrolysate for uterine infection treatment: a patent evaluation (WO2011132191) ⬇️

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization

Casein kinases as potential therapeutic targets

Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential

Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects

Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships

Covalently bound DNA on naked iron oxide nanoparticles: Intelligent colloidal nano-vector for cell transfection.

Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2.

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.

Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation

Development of a yeast-based system to identify new hBRAFV600E functional interactors

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

Elucidation of the ribonuclease a aggregation process mediated by 3D domain swapping: A computational approach reveals possible new multimeric structures

Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases

Fam20C is under the control of sphingolipid signaling in human cell lines

Glutathione Peroxidase 4

Glutathione Peroxidase-4

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center.

How druggable is protein kinase CK2?

Hydrophobic Derivatives of Glycopeptide Antibiotics as Inhibitors of Protein Kinases

Identification of Ellagic Acid as Potent Inhibitor of Protein Kinase CK2: A Successful Example of a Virtual Screening Application

Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening

Inactivation of the glutathione peroxidase GPx4 by the ferroptosis-inducing molecule RSL3 requires the adaptor protein 14-3-3ε

Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study

Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight

Isoform specific phosphorylation of p53 by protein kinase CK1.

Kinase CK2 inhibition: an update.

Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases

Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

Protein kinase CK2 inhibitors: a patent review

Pyrazoloquinazoline Tricyclic System as Novel Scaffold to Design New Kinase CK2 Inhibitors

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.

Stealth Iron Oxide Nanoparticles for Organotropic Drug Targeting

Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

TG2 regulates the heat-shock response by the post-translational modification of HSF1

Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors

Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.

The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design

The Golgi "casein kinase" Fam20C is a genuine "phosvitin kinase" and phosphorylates polyserine stretches devoid of the canonical consensus

The Regulatory β Subunit of Protein Kinase CK2 Contributes to the Recognition of the Substrate Consensus Sequence. A Study with an eIF2β-Derived Peptide†

The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation

The acidophilic kinases PLK2 and PLK3: structure, substrate targeting and inhibition.

The dark side of protein kinase CK2 inhibition

The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131.

The landscape of BRAF transcript and protein variants in human cancer.

The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.

The role of the N-terminal domain in the regulation of the "constitutively active" conformation of protein kinase CK2α: insight from a molecular dynamics investigation

The selectivity of inhibitors of protein kinase CK2: an update

Tools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases

Understanding mammalian glutathione peroxidase 7 in the light of its homologs.

Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer

Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors