List of works - Jeffrey J Babon

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

scientific article

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

scientific article published on 28 November 2018

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

scientific article

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

scientific article

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections

scientific article

CIS is a potent checkpoint in NK cell-mediated tumor immunity

scientific article

COL4A4 mutation in thin basement membrane disease previously described in Alport syndrome

scientific article (publication date: August 2001)

Chemical cleavage reactions of DNA on solid support: application in mutation detection ⬇️

scientific article published on May 13, 2003

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.

scientific article published on 26 October 2015

Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling

scientific article

Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops

scientific article

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

scientific article published on 01 November 2019

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.

scientific article published on February 2016

Expression and Purification of JAK1 and SOCS1 for Structural and Biochemical Studies.

scientific article published in January 2018

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia

scientific article

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

scientific article published on 17 May 2019

Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.

scientific article

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

scientific article published on 01 July 2019

Identification of a second binding site on the TRIM25 B30.2 domain.

scientific article published on 19 December 2017

Inhibition of IL-6 family cytokines by SOCS3.

scientific article published on 10 January 2014

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

scientific article

Interaction of linear homologous DNA duplexes via Holliday junction formation.

scientific article published in January 2001

JAK1 Takes a FERM Hold of Type II Cytokine Receptors.

scientific article published in June 2016

Letter to the Editor: Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2)

scientific article published in January 2005

Leukemia inhibitory factor (LIF)

scientific article

Measuring translational diffusion of 15N-enriched biomolecules in complex solutions with a simplified 1H-15N HMQC-filtered BEST sequence

scientific article published on 21 May 2018

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

scientific article

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6Rα)

scientific article published on 01 October 2019

Mutation detection using fluorescent enzyme mismatch cleavage with T4 endonuclease VII

scientific article published on 01 June 1999

NMR measurement of biomolecular translational and rotational motion for evaluating changes of protein oligomeric state in solution

scientific article published in April 2022

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS

scientific article published on 13 January 2014

Neutrophils Require SHP1 To Regulate IL-1 Production and Prevent Inflammatory Skin Disease

scientific article published on 15 December 2010

Novel TP53 gene mutations in tumors of Russian patients with breast cancer detected using a new solid phase chemical cleavage of mismatch method and identified by sequencing.

scientific article

Protein effective rotational correlation times from translational self-diffusion coefficients measured by PFG-NMR

scientific article published on 14 June 2008

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

scientific article published on 09 December 2019

Purification of SOCS (Suppressor of Cytokine Signaling) SH2 Domains for Structural and Functional Studies

scientific article published in January 2017

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates

scientific article

Regulation of Janus kinases by SOCS proteins

scientific article published on August 2013

Resonance assignment and secondary structure of an N-terminal fragment of the human La protein

article

Resonance assignment for the N-terminal region of the eukaryotic initiation factor 5 (eIF5)

scientific article published on 01 January 2006

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

scientific journal article

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

scientific article

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

scientific journal article

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein

scientific journal article

Structural studies on Plasmodium vivax merozoite surface protein-1

scientific article

Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5

scientific article

Structure and Sodium Channel Activity of an Excitatory I 1 -Superfamily Conotoxin † , ‡

scientific article

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

scientific article published on January 2013

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

scientific article published in February 2012

Suppression of cytokine signaling: the SOCS perspective

scientific article published on 30 March 2013

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

scientific article

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

scientific article published on 14 February 2017

Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum

scientific article published on 17 September 2003

TGF-β and IL-6 family signalling crosstalk: an integrated model

scientific article

TLR7 gain-of-function genetic variation causes human lupus

scientific article published on 27 April 2022

Techniques to examine nucleotide binding by pseudokinases

scientific article published on August 2013

The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

scientific article

The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression

scientific article published on March 2009

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

scientific article published on 20 December 2005

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

scientific article

The biology and mechanism of action of suppressor of cytokine signaling 3

scientific article

The molecular basis of JAK/STAT inhibition by SOCS1.

scientific article published on 19 April 2018

The molecular details of cytokine signaling via the JAK/STAT pathway

scientific article published on 01 December 2018

The molecular regulation of Janus kinase (JAK) activation

scientific article

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

scientific article

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

scientific article published on April 2006

The use of resolvases T4 endonuclease VII and T7 endonuclease I in mutation detection.

scientific article

VHL: Cullin-g the hypoxic response.

scientific article published in March 2015

List of works by Jeffrey J Babon

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections

CIS is a potent checkpoint in NK cell-mediated tumor immunity

COL4A4 mutation in thin basement membrane disease previously described in Alport syndrome

Chemical cleavage reactions of DNA on solid support: application in mutation detection ⬇️

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.

Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling

Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.

Expression and Purification of JAK1 and SOCS1 for Structural and Biochemical Studies.

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

Identification of a second binding site on the TRIM25 B30.2 domain.

Inhibition of IL-6 family cytokines by SOCS3.

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

Interaction of linear homologous DNA duplexes via Holliday junction formation.

JAK1 Takes a FERM Hold of Type II Cytokine Receptors.

Letter to the Editor: Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2)

Leukemia inhibitory factor (LIF)

Measuring translational diffusion of 15N-enriched biomolecules in complex solutions with a simplified 1H-15N HMQC-filtered BEST sequence

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6Rα)

Mutation detection using fluorescent enzyme mismatch cleavage with T4 endonuclease VII

NMR measurement of biomolecular translational and rotational motion for evaluating changes of protein oligomeric state in solution

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS

Neutrophils Require SHP1 To Regulate IL-1 Production and Prevent Inflammatory Skin Disease

Novel TP53 gene mutations in tumors of Russian patients with breast cancer detected using a new solid phase chemical cleavage of mismatch method and identified by sequencing.

Protein effective rotational correlation times from translational self-diffusion coefficients measured by PFG-NMR

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Purification of SOCS (Suppressor of Cytokine Signaling) SH2 Domains for Structural and Functional Studies

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates

Regulation of Janus kinases by SOCS proteins

Resonance assignment and secondary structure of an N-terminal fragment of the human La protein

Resonance assignment for the N-terminal region of the eukaryotic initiation factor 5 (eIF5)

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein

Structural studies on Plasmodium vivax merozoite surface protein-1

Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5

Structure and Sodium Channel Activity of an Excitatory I 1 -Superfamily Conotoxin † , ‡

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

Suppression of cytokine signaling: the SOCS perspective

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum

TGF-β and IL-6 family signalling crosstalk: an integrated model

TLR7 gain-of-function genetic variation causes human lupus

Techniques to examine nucleotide binding by pseudokinases

The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

The biology and mechanism of action of suppressor of cytokine signaling 3

The molecular basis of JAK/STAT inhibition by SOCS1.

The molecular details of cytokine signaling via the JAK/STAT pathway

The molecular regulation of Janus kinase (JAK) activation

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

The use of resolvases T4 endonuclease VII and T7 endonuclease I in mutation detection.

VHL: Cullin-g the hypoxic response.