List of works - Dennis L Wright

Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination

scientific article published on 26 October 2004

Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative

scientific article published on 05 June 2006

Antibacterial Antifolates: From Development through Resistance to the Next Generation

scientific article published on 28 June 2016

Antifolate agents: a patent review (2006 - 2010).

scientific article

Antifolate agents: a patent review (2010 - 2013).

scientific article published on 22 March 2014

Bicyclo[3.2.1]octane synthons from cyclopropenes: functionalization of cycloadducts by nucleophilic additions.

scientific article

Bridged synthons from tetrabromocyclopropene: studies on the rearrangement of the primary Diels-Alder adduct with 2,5-dimethylfuran.

scientific article

Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates.

scientific article

Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens

scientific article published on 5 May 2016

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations

scientific article published on 16 June 2016

Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

scientific article published on 10 February 2022

Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates

scientific article published on 04 January 2016

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

scientific article

Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity

scientific article

Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin A.

scientific article published on 10 March 2014

Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.

scientific article published on 21 September 2013

Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.

scientific article

Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301

scientific article

Electrochemical annulation of five-membered rings through dearomatization of furans and thiophenes

scientific article published on 16 November 2005

Elucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate Reductase

scientific article

Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis

scientific article published on 02 February 2007

Highly substituted oxabicyclic derivatives from furan: synthesis of (±)-platensimycin

scientific article published on 31 March 2011

In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.

scientific article

Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.

scientific article published on 08 January 2009

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.

scientific article published on 26 November 2016

Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.

scientific article

Natural products in parallel synthesis: triazole libraries of nonactic acid

scientific article

New chiral building blocks from tetrabromocyclopropene and furan.

scientific article published in October 2004

Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases.

scientific article

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

scientific article published on 8 July 2015

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells

scientific article published on 16 June 2017

Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.

scientific article published on 20 September 2016

Oxabicyclo[3.2.1]octane derivatives as highly reactive dienophiles: synthesis of bicyclo[5.n.0] systems

scientific article published on 01 February 2005

Pharmaceutical analysis of a novel propargyl-linked antifolate antibiotic in the mouse

scientific article published on 6 March 2017

Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals

scientific article published on 03 October 2005

Post-Glycosylation Diversification (PGD): An Approach for Assembling Collections of Glycosylated Small Molecules

scientific article published on 15 January 2019

Probing the Active Site ofCandida glabrataDihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors

scientific article

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

scientific article

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

scientific article

Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance

scientific article

Resolution of Methyl Nonactate byRhodococcuserythropolisunder Aerobic and Anaerobic Conditions

scientific article published on 01 February 2006

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites

scientific article

Silver-promoted reactions of bicyclo[3.2.1]octadiene derivatives

scientific article published on 01 June 2002

Stereodivergent resolution of oxabicyclic ketones: preparation of key intermediates for platensimycin and other natural products.

scientific article published in October 2013

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species

scientific article

Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens

scientific article published on 15 February 2019

Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase

scientific article

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

scientific article published on 14 June 2019

Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function

scientific article

Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells

scientific article

Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase

scientific article

Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine

scientific article published on 01 April 2011

The challenge of resistance in antimicrobial drug development.

scientific article

The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings.

scientific article published in April 2006

The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs

scientific article published on 01 November 2012

The tandem ring opening/ring closing metathesis route to oxaspirocycles: an approach to phelligridin G.

scientific article published on 21 February 2013

Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus

scientific article published on 15 October 2019

Towards new antifolates targeting eukaryotic opportunistic infections

scientific article published on 23 January 2009

Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.

scientific article

Two-step electrochemical annulation for the assembly of polycyclic systems

scientific article published on 01 October 2002

USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms

scientific article published on 4 October 2017

Unusual influence of substituents on ring-opening metathesis reactions

scientific article published on 01 December 2001

Viridin analogs derived from steroidal building blocks

scientific article published on 13 September 2012

Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein.

scientific article published on 17 January 2012

List of works by Dennis L Wright

Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination

Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative

Antibacterial Antifolates: From Development through Resistance to the Next Generation

Antifolate agents: a patent review (2006 - 2010).

Antifolate agents: a patent review (2010 - 2013).

Bicyclo[3.2.1]octane synthons from cyclopropenes: functionalization of cycloadducts by nucleophilic additions.

Bridged synthons from tetrabromocyclopropene: studies on the rearrangement of the primary Diels-Alder adduct with 2,5-dimethylfuran.

Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates.

Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations

Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity

Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin A.

Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.

Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.

Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301

Electrochemical annulation of five-membered rings through dearomatization of furans and thiophenes

Elucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate Reductase

Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis

Highly substituted oxabicyclic derivatives from furan: synthesis of (±)-platensimycin

In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.

Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.

Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.

Natural products in parallel synthesis: triazole libraries of nonactic acid

New chiral building blocks from tetrabromocyclopropene and furan.

Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases.

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells

Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.

Oxabicyclo[3.2.1]octane derivatives as highly reactive dienophiles: synthesis of bicyclo[5.n.0] systems

Pharmaceutical analysis of a novel propargyl-linked antifolate antibiotic in the mouse

Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals

Post-Glycosylation Diversification (PGD): An Approach for Assembling Collections of Glycosylated Small Molecules

Probing the Active Site ofCandida glabrataDihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance

Resolution of Methyl Nonactate byRhodococcuserythropolisunder Aerobic and Anaerobic Conditions

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites

Silver-promoted reactions of bicyclo[3.2.1]octadiene derivatives

Stereodivergent resolution of oxabicyclic ketones: preparation of key intermediates for platensimycin and other natural products.

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species

Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens

Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function

Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells

Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase

Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine

The challenge of resistance in antimicrobial drug development.

The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings.

The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs

The tandem ring opening/ring closing metathesis route to oxaspirocycles: an approach to phelligridin G.

Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus

Towards new antifolates targeting eukaryotic opportunistic infections

Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.

Two-step electrochemical annulation for the assembly of polycyclic systems

USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms

Unusual influence of substituents on ring-opening metathesis reactions

Viridin analogs derived from steroidal building blocks

Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein.