List of works - Harri Niinikoski

A novel common variant in DCST2 is associated with length in early life and height in adulthood

scientific article published on 3 October 2014

Abnormal coagulation and enhanced fibrinolysis due to lysinuric protein intolerance associates with bleeds and renal impairment

scientific article published on 02 August 2018

Advanced dental maturity of Finnish 6- to 12-yr-old children is associated with high energy intake

scientific article

Age-Specific Estimates and Comparisons of Youth Tri-Ponderal Mass Index and Body Mass Index in Predicting Adult Obesity-Related Outcomes

scientific article published on 19 November 2019

Alexander disease as a cause of nocturnal vomiting in a 7-year-old girl

scientific article published on 6 May 2009

Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis

scientific journal article

Association of Adiponectin with Adolescent Cardiovascular Health in a Dietary Intervention Study

scientific article published on 15 May 2015

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of fitness with vascular intima-media thickness and elasticity in adolescence

scientific article published on 10 June 2013

Association of physical activity with vascular endothelial function and intima-media thickness

scientific article published on 03 October 2011

Attainment of Targets of the 20-Year Infancy-Onset Dietary Intervention and Blood Pressure Across Childhood and Young Adulthood: The Special Turku Coronary Risk Factor Intervention Project (STRIP)

scientific article published on 14 September 2020

Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1.

scientific article published on 29 September 2011

Behavior of 3-year old children in a prospective randomized trial of reduced saturated fat and cholesterol diet since infancy: the STRIP baby project

scientific article published on 01 January 1997

Blood pressure is lower in children and adolescents with a low-saturated-fat diet since infancy: the special turku coronary risk factor intervention project

scientific article published on 13 April 2009

Breast milk fatty acid composition differs between overweight and normal weight women: the STEPS Study

scientific article published on 26 May 2012

Carbohydrate intake, serum lipids and apolipoprotein E phenotype show association in children.

scientific article published on 26 June 2009

Cardiometabolic Determinants of Carotid and Aortic Distensibility From Childhood to Early Adulthood

scientific article

Cardiovascular disease risk factors in young children in the STRIP baby project.

scientific article

Cardiovascular disease risk factors in young children in the STRIP baby project. Special Turku coronary Risk factor Intervention Project for children

scientific article published on 01 April 1999

Carnitine deficiency and L-carnitine supplementation in lysinuric protein intolerance

scientific article published in April 2008

Case 2: Two young children with polydipsia, polyuria and severe hypertension

scientific article published on 01 July 2006

Cholesterol measurement by reflotron dry chemistry in infants, children and adults

scientific article published on 01 February 1994

Cohort Profile: the STRIP Study (Special Turku Coronary Risk Factor Intervention Project), an Infancy-onset Dietary and Life-style Intervention Trial

scientific article published on 22 April 2008

Combined hyperlipidemia in patients with lysinuric protein intolerance

scientific article published on 23 February 2010

Constantly low HDL-cholesterol concentration relates to endothelial dysfunction and increased in vivo LDL-oxidation in healthy young men

scientific article published on 01 November 1999

Correlation of toddlers' serum lipoprotein(a) concentration with parental values and grandparents' coronary heart disease: the STRIP baby study

scientific article published on 01 April 1996

Decreased large artery distensibility in borderline hypertension is related to increased in vivo low-density lipoprotein oxidation

scientific article published on 01 January 2002

Development of overweight in an atherosclerosis prevention trial starting in early childhood. The STRIP study

scientific article published on 01 April 2006

Dietary Fats and Atherosclerosis From Childhood to Adulthood

scientific article published on 24 March 2020

Dietary and lifestyle counselling reduces the clustering of overweight-related cardiometabolic risk factors in adolescents

scientific article published on 11 December 2009

Dietary fiber does not displace energy but is associated with decreased serum cholesterol concentrations in healthy children

scientific article published on 13 January 2010

Dietary patterns and nutrient intakes of 7-year-old children taking part in an atherosclerosis prevention project in Finland

scientific article published in April 2002

Distensibility of the aorta and carotid artery and left ventricular mass from childhood to early adulthood

scientific article published on 27 October 2014

Dysfunction in macrophage toll-like receptor signaling caused by an inborn error of cationic amino acid transport

scientific article published on 22 July 2015

Early impairment of coronary flow reserve in young men with borderline hypertension.

scientific article published on July 1998

Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood

scientific article published on 31 January 2018

Effect of Infancy-onset Dietary Intervention on Salivary Cholesterol of Children: a Randomized Controlled Trial

scientific article published on 07 April 2011

Effect of repeated dietary counseling on serum lipoproteins from infancy to adulthood

scientific article published on 13 February 2012

Effects of 20-year infancy-onset dietary counselling on cardiometabolic risk factors in the Special Turku Coronary Risk Factor Intervention Project (STRIP): 6-year post-intervention follow-up

scientific article published on 01 May 2020

Effects of a home-based exercise program on metabolic risk factors and fitness in long-term survivors of childhood acute lymphoblastic leukemia

scientific article published on 19 December 2011

Endothelial function in healthy 11-year-old children after dietary intervention with onset in infancy: the Special Turku Coronary Risk Factor Intervention Project for children (STRIP).

scientific article

Endothelial function in long-term survivors of childhood acute lymphoblastic leukemia: Effects of a home-based exercise program

scientific article published on 20 April 2013

Essential fats for future health. Proceedings of the 9th Unilever Nutrition Symposium, 26-27 May 2010.

scientific article published on December 2010

Exploring the transcriptomic variation caused by the Finnish founder mutation of lysinuric protein intolerance (LPI).

scientific article published on 16 December 2011

Fatty acid composition of serum cholesterol esters as a reflector of low-saturated-fat, low-cholesterol diet in young children: the STRIP project. The Special Turku coronary Risk factor Intervention Project

scientific article published on 01 April 2000

Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study

scientific article published on 11 December 2015

Genitopatellar syndrome in an adolescent female with severe osteoporosis and endocrine abnormalities.

scientific article

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

scientific article

Genome-wide associations for birth weight and correlations with adult disease

scientific article

Glycogen storage disease type IX: High variability in clinical phenotype

scientific article

Growth hormone therapy is safe and effective in patients with lysinuric protein intolerance

scientific article

Growth patterns and obesity development in overweight or normal-weight 13-year-old adolescents: the STRIP study

scientific article published in October 2008

Growth until 3 years of age in a prospective, randomized trial of a diet with reduced saturated fat and cholesterol.

scientific article

Hazards associated with pregnancies and deliveries in lysinuric protein intolerance

scientific article

High sucrose intake at 3 years of age is associated with increased salivary counts of mutans streptococci and lactobacilli, and with increased caries rate from 3 to 16 years of age.

scientific article

High sucrose intake is associated with poor quality of diet and growth between 13 months and 9 years of age: the special Turku Coronary Risk Factor Intervention Project

scientific article published in June 2008

Home-Based Exercise Training Improves Left Ventricle Diastolic Function in Survivors of Childhood ALL: A Tissue Doppler and Velocity Vector Imaging Study

scientific article published on 16 May 2016

Hyperglycemia and lower diet quality in pregnant overweight women and increased infant size at birth and at 13 months of age--STEPS study

scientific article published in February 2013

Ideal cardiovascular health in adolescence: effect of lifestyle intervention and association with vascular intima-media thickness and elasticity (the Special Turku Coronary Risk Factor Intervention Project for Children [STRIP] study).

scientific article published on 23 April 2013

Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS).

scientific article published on 23 December 2016

Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI).

scientific article published on 27 May 2016

Impact of Repeated Dietary Counseling Between Infancy and 14 Years of Age on Dietary Intakes and Serum Lipids and Lipoproteins

scientific article published on 13 August 2007

Impact of nutrition counselling on nutrition knowledge and nutrient intake of 7- to 9-y-old children in an atherosclerosis prevention project

scientific article published in January 2004

Infancy-onset dietary counseling of low-saturated-fat diet improves insulin sensitivity in healthy adolescents 15-20 years of age: the Special Turku Coronary Risk Factor Intervention Project (STRIP) study

scientific article published on 25 June 2013

Influence of Cardiovascular Risk Status on Coronary Flow Reserve in Healthy Young Men

scientific article published on 01 June 1997

Influence of dietary fat on the nutrient intake and growth of children from 1 to 5 y of age: the Special Turku Coronary Risk Factor Intervention Project

scientific article published on 01 March 1999

Inhaled Sargramostim Induces Resolution of Pulmonary Alveolar Proteinosis in Lysinuric Protein Intolerance

scientific article published on 26 October 2016

Initiation and exclusivity of breastfeeding: association with mothers' and fathers' prenatal and postnatal depression and marital distress

scientific article published on 30 January 2016

Insulin-induced lipoatrophy in children

scientific article published on January 2010

Intake and indicators of iron and zinc status in children consuming diets low in saturated fat and cholesterol: the STRIP baby study. Special Turku Coronary Risk Factor Intervention Project for Babies

scientific article published on 01 September 1997

Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children

scientific article published on 8 October 2014

Is carbohydrate intake in the first years of life related to future risk of NCDs?

scientific article published on 11 July 2012

Large-artery elastic properties in young men : relationships to serum lipoproteins and oxidized low-density lipoproteins

scientific article published on 01 February 1999

Left ventricular mass and geometry in adolescence: early childhood determinants

scientific article published on 17 September 2012

Long-term oral lysine supplementation in lysinuric protein intolerance

scientific article published in February 2007

Longitudinal child-oriented dietary intervention: Association with parental diet and cardio-metabolic risk factors. The Special Turku Coronary Risk Factor Intervention Project

scientific article published on 20 July 2017

Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study

scientific article published on 05 November 2018

Low-saturated fat, low-cholesterol diet in 3-year-old children: effect on intake and composition of trans fatty acids and other fatty acids in serum phospholipid fraction-The STRIP study. Special Turku coronary Risk factor Intervention Project [...]

scientific article

Low-saturated-fat and low-cholesterol diet does not alter pubertal development and hormonal status in adolescents

scientific article published on 20 July 2018

Maternal and fetal genetic contribution to gestational weight gain

article

Maternal and fetal genetic contribution to gestational weight gain.

scientific article published on 9 October 2017

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

scientific article published on 01 May 2019

Maternal overweight impacts infant feeding patterns--the STEPS Study.

scientific article

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

scientific article published on 07 May 2020

Metabolic syndrome from adolescence to early adulthood: effect of infancy-onset dietary counseling of low saturated fat: the Special Turku Coronary Risk Factor Intervention Project (STRIP).

scientific article published on 20 January 2015

Modifying coronary heart disease risk factors in children: is it ever too early to start?

scientific article

Mothers' restrictive eating and food neophobia and fathers' dietary quality are associated with breast-feeding duration and introduction of solid foods: the STEPS study

scientific article published on 4 December 2014

Neonatal hypothyroidism after amiodarone therapy

scientific article published on 21 March 2007

Nephropathy advancing to end-stage renal disease: a novel complication of lysinuric protein intolerance

scientific article

Net portal absorption of enterally fed alpha-ketoglutarate is limited in young pigs

scientific article published on 01 November 2002

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

Nutrient intake in lysinuric protein intolerance

scientific article published on 21 June 2007

Nutrient intake, weight, and Leu7Pro polymorphism in prepro-neuropeptide Y in children

scientific article published on 15 August 2006

Nutrient intakes by young children in a prospective randomized trial of a low-saturated fat, low-cholesterol diet. The STRIP Baby Project. Special Turku Coronary Risk Factor Intervention Project for Babies

scientific article published on 01 February 1997

Nutrition knowledge and food intake of seven-year-old children in an atherosclerosis prevention project with onset in infancy: the impact of child-targeted nutrition counselling given to the parents

scientific article published in April 2001

Onset of small intestinal atrophy is associated with reduced intestinal blood flow in TPN-fed neonatal piglets.

scientific article published in June 2004

PROKR2 mutations in autosomal recessive Kallmann syndrome

scientific article

Parental nutrition knowledge and nutrient intake in an atherosclerosis prevention project: the impact of child-targeted nutrition counselling

scientific article published on 01 August 2003

Physical activity and fitness in adolescent and young adult long-term survivors of childhood acute lymphoblastic leukaemia

scientific article

Prospective randomized trial of low-saturated-fat, low-cholesterol diet during the first 3 years of life. The STRIP baby project.

scientific article published in September 1996

Prospective, randomized, infancy-onset trial of the effects of a low-saturated-fat, low-cholesterol diet on serum lipids and lipoproteins before school age: The Special Turku Coronary Risk Factor Intervention Project (STRIP).

scientific article published in September 2000

Psychological wellbeing in 20-year-old adults receiving repeated lifestyle counselling since infancy

scientific article published on 29 May 2015

Regulation of growth of 7- to 36-month-old children by energy and fat intake in the prospective, randomized STRIP baby trial.

scientific article published in November 1997

Response to the letter to the editor "Indices of insulin sensitivity and resistance: adequate logarithmic transformation are needed to keep mathematical equivalence" by Tomoyuki Kawada

scientific article published on 9 April 2013

Risk factors for coronary heart disease in children and young adults.

scientific article

Sonography in the detection of achilles tendon xanthomata in children with familial hypercholesterolaemia

scientific article published on 01 November 1994

Special Turku Coronary Risk Factor Intervention Project for Babies (STRIP)

scientific article published on 01 November 2000

Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids

scientific article published on 02 August 2018

Sucrose intake since infancy and dental health in 10-year-old children

scientific article published in March 2004

Tandem mass spectrometric analysis of human milk triacylglycerols from normal weight and overweight mothers on different diets

scientific article

Temperament profiles are associated with dietary behavior from childhood to adulthood

scientific article published on 03 April 2020

The association of dietary alpha-linolenic acid with blood pressure and subclinical atherosclerosis in people born small for gestational age: the Special Turku Coronary Risk Factor Intervention Project study

scientific article published on 18 February 2015

The effect of dietary intervention on paraffin-stimulated saliva and dental health of children participating in a randomized controlled trial.

scientific article

The initiatives and outcomes for cardiovascular risks that can be achieved through paediatric counselling

scientific article published on February 2009

Total parenteral nutrition adversely affects gut barrier function in neonatal piglets

scientific article published on 11 September 2003

Urine Beta2-Microglobulin Is an Early Marker of Renal Involvement in LPI

scientific article published on 30 June 2015

When and how to start prevention of atherosclerosis? Lessons from the Cardiovascular Risk in the Young Finns Study and the Special Turku Coronary Risk Factor Intervention Project

scientific article published on 30 August 2011

[Congenital disorder of glycosylation type Ia (CDG Ia) - underdiagnosed entity?].

scientific article

[Milk is coming out from the baby's thoracic cavity...]

scientific article published on 01 January 2001

[Phenylketonuria].

scientific article published in January 2009

List of works by Harri Niinikoski

A novel common variant in DCST2 is associated with length in early life and height in adulthood

Abnormal coagulation and enhanced fibrinolysis due to lysinuric protein intolerance associates with bleeds and renal impairment

Advanced dental maturity of Finnish 6- to 12-yr-old children is associated with high energy intake

Age-Specific Estimates and Comparisons of Youth Tri-Ponderal Mass Index and Body Mass Index in Predicting Adult Obesity-Related Outcomes

Alexander disease as a cause of nocturnal vomiting in a 7-year-old girl

Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis

Association of Adiponectin with Adolescent Cardiovascular Health in a Dietary Intervention Study

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

Association of fitness with vascular intima-media thickness and elasticity in adolescence

Association of physical activity with vascular endothelial function and intima-media thickness

Attainment of Targets of the 20-Year Infancy-Onset Dietary Intervention and Blood Pressure Across Childhood and Young Adulthood: The Special Turku Coronary Risk Factor Intervention Project (STRIP)

Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1.

Behavior of 3-year old children in a prospective randomized trial of reduced saturated fat and cholesterol diet since infancy: the STRIP baby project

Blood pressure is lower in children and adolescents with a low-saturated-fat diet since infancy: the special turku coronary risk factor intervention project

Breast milk fatty acid composition differs between overweight and normal weight women: the STEPS Study

Carbohydrate intake, serum lipids and apolipoprotein E phenotype show association in children.

Cardiometabolic Determinants of Carotid and Aortic Distensibility From Childhood to Early Adulthood

Cardiovascular disease risk factors in young children in the STRIP baby project.

Cardiovascular disease risk factors in young children in the STRIP baby project. Special Turku coronary Risk factor Intervention Project for children

Carnitine deficiency and L-carnitine supplementation in lysinuric protein intolerance

Case 2: Two young children with polydipsia, polyuria and severe hypertension

Cholesterol measurement by reflotron dry chemistry in infants, children and adults

Cohort Profile: the STRIP Study (Special Turku Coronary Risk Factor Intervention Project), an Infancy-onset Dietary and Life-style Intervention Trial

Combined hyperlipidemia in patients with lysinuric protein intolerance

Constantly low HDL-cholesterol concentration relates to endothelial dysfunction and increased in vivo LDL-oxidation in healthy young men

Correlation of toddlers' serum lipoprotein(a) concentration with parental values and grandparents' coronary heart disease: the STRIP baby study

Decreased large artery distensibility in borderline hypertension is related to increased in vivo low-density lipoprotein oxidation

Development of overweight in an atherosclerosis prevention trial starting in early childhood. The STRIP study

Dietary Fats and Atherosclerosis From Childhood to Adulthood

Dietary and lifestyle counselling reduces the clustering of overweight-related cardiometabolic risk factors in adolescents

Dietary fiber does not displace energy but is associated with decreased serum cholesterol concentrations in healthy children

Dietary patterns and nutrient intakes of 7-year-old children taking part in an atherosclerosis prevention project in Finland

Distensibility of the aorta and carotid artery and left ventricular mass from childhood to early adulthood

Dysfunction in macrophage toll-like receptor signaling caused by an inborn error of cationic amino acid transport

Early impairment of coronary flow reserve in young men with borderline hypertension.

Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood

Effect of Infancy-onset Dietary Intervention on Salivary Cholesterol of Children: a Randomized Controlled Trial

Effect of repeated dietary counseling on serum lipoproteins from infancy to adulthood

Effects of 20-year infancy-onset dietary counselling on cardiometabolic risk factors in the Special Turku Coronary Risk Factor Intervention Project (STRIP): 6-year post-intervention follow-up

Effects of a home-based exercise program on metabolic risk factors and fitness in long-term survivors of childhood acute lymphoblastic leukemia

Endothelial function in healthy 11-year-old children after dietary intervention with onset in infancy: the Special Turku Coronary Risk Factor Intervention Project for children (STRIP).

Endothelial function in long-term survivors of childhood acute lymphoblastic leukemia: Effects of a home-based exercise program

Essential fats for future health. Proceedings of the 9th Unilever Nutrition Symposium, 26-27 May 2010.

Exploring the transcriptomic variation caused by the Finnish founder mutation of lysinuric protein intolerance (LPI).

Fatty acid composition of serum cholesterol esters as a reflector of low-saturated-fat, low-cholesterol diet in young children: the STRIP project. The Special Turku coronary Risk factor Intervention Project

Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study

Genitopatellar syndrome in an adolescent female with severe osteoporosis and endocrine abnormalities.

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

Genome-wide associations for birth weight and correlations with adult disease

Glycogen storage disease type IX: High variability in clinical phenotype

Growth hormone therapy is safe and effective in patients with lysinuric protein intolerance

Growth patterns and obesity development in overweight or normal-weight 13-year-old adolescents: the STRIP study

Growth until 3 years of age in a prospective, randomized trial of a diet with reduced saturated fat and cholesterol.

Hazards associated with pregnancies and deliveries in lysinuric protein intolerance

High sucrose intake at 3 years of age is associated with increased salivary counts of mutans streptococci and lactobacilli, and with increased caries rate from 3 to 16 years of age.

High sucrose intake is associated with poor quality of diet and growth between 13 months and 9 years of age: the special Turku Coronary Risk Factor Intervention Project

Home-Based Exercise Training Improves Left Ventricle Diastolic Function in Survivors of Childhood ALL: A Tissue Doppler and Velocity Vector Imaging Study

Hyperglycemia and lower diet quality in pregnant overweight women and increased infant size at birth and at 13 months of age--STEPS study

Ideal cardiovascular health in adolescence: effect of lifestyle intervention and association with vascular intima-media thickness and elasticity (the Special Turku Coronary Risk Factor Intervention Project for Children [STRIP] study).

Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS).

Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI).

Impact of Repeated Dietary Counseling Between Infancy and 14 Years of Age on Dietary Intakes and Serum Lipids and Lipoproteins

Impact of nutrition counselling on nutrition knowledge and nutrient intake of 7- to 9-y-old children in an atherosclerosis prevention project

Infancy-onset dietary counseling of low-saturated-fat diet improves insulin sensitivity in healthy adolescents 15-20 years of age: the Special Turku Coronary Risk Factor Intervention Project (STRIP) study

Influence of Cardiovascular Risk Status on Coronary Flow Reserve in Healthy Young Men

Influence of dietary fat on the nutrient intake and growth of children from 1 to 5 y of age: the Special Turku Coronary Risk Factor Intervention Project

Inhaled Sargramostim Induces Resolution of Pulmonary Alveolar Proteinosis in Lysinuric Protein Intolerance

Initiation and exclusivity of breastfeeding: association with mothers' and fathers' prenatal and postnatal depression and marital distress

Insulin-induced lipoatrophy in children

Intake and indicators of iron and zinc status in children consuming diets low in saturated fat and cholesterol: the STRIP baby study. Special Turku Coronary Risk Factor Intervention Project for Babies

Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children

Is carbohydrate intake in the first years of life related to future risk of NCDs?

Large-artery elastic properties in young men : relationships to serum lipoproteins and oxidized low-density lipoproteins

Left ventricular mass and geometry in adolescence: early childhood determinants

Long-term oral lysine supplementation in lysinuric protein intolerance

Longitudinal child-oriented dietary intervention: Association with parental diet and cardio-metabolic risk factors. The Special Turku Coronary Risk Factor Intervention Project

Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study

Low-saturated fat, low-cholesterol diet in 3-year-old children: effect on intake and composition of trans fatty acids and other fatty acids in serum phospholipid fraction-The STRIP study. Special Turku coronary Risk factor Intervention Project [...]

Low-saturated-fat and low-cholesterol diet does not alter pubertal development and hormonal status in adolescents