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List of works by Jeffrey W. Holmes

A Comparison of Phenomenologic Growth Laws for Myocardial Hypertrophy

scientific article published in March 2017

A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation

scientific article

A multiscale model of cardiac concentric hypertrophy incorporating both mechanical and hormonal drivers of growth

scientific article published on 24 September 2020

A novel method for quantitating delayed enhancement of the left atrium.

scientific article published on 2 February 2011

Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling

scientific article published on December 2006

An ultrasound-driven kinematic model for deformation of the infarcted mouse left ventricle incorporating a near-incompressibility constraint

scientific article

Anisotropic reinforcement of acute anteroapical infarcts improves pump function

scientific article

Cardiovascular solid mechanics grows and remodels

scientific article published on 09 December 2011

Changes in Global and Regional Mechanics Due to Atrial Fibrillation: Insights from a Coupled Finite-Element and Circulation Model

scientific article

Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure

scientific article published on 01 November 2000

Clinical Applications of Patient-Specific Models: The Case for a Simple Approach

scientific article published on 16 February 2018

Collagen fiber alignment does not explain mechanical anisotropy in fibroblast populated collagen gels

scientific article published in October 2007

Comparison of quantitative wall-motion analysis and strain for detection of coronary stenosis with three-dimensional dobutamine stress echocardiography.

scientific article

Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: a primary role of mechanical unloading underlying reverse remodeling

scientific article published on 01 August 2001

Computational Model Predicts Paracrine and Intracellular Drivers of Fibroblast Phenotype After Myocardial Infarction

scientific article published on 21 March 2020

Computational modeling of cardiac fibroblasts and fibrosis

scientific article

Contribution of extracellular matrix to the mechanical properties of the heart

scientific article

Coronary Occlusion Detection with 4D Optical Flow Based Strain Estimation on 4D Ultrasound

Coupled agent-based and finite-element models for predicting scar structure following myocardial infarction

scientific article

Creating alignment and anisotropy in engineered heart tissue: role of boundary conditions in a model three-dimensional culture system

scientific article published in August 2003

Crossing Into the Next Frontier of Cardiac Extracellular Matrix Research

scientific article published on October 2016

Depressed regional deformation near anterior papillary muscle ⬇️

scientific article published on July 1, 1995

Dynamic cardiac information from optical flow using four dimensional ultrasound

scientific article published in January 2005

Effect of Scar Compaction on the Therapeutic Efficacy of Anisotropic Reinforcement Following Myocardial Infarction in the Dog.

scientific article

Effect of ablation pattern on mechanical function in the atrium

scientific article

Effects of sequential biventricular pacing during acute right ventricular pressure overload

scientific article published on 02 June 2006

Effects of stretch and shortening on gene expression in intact myocardium

scientific article

Electromechanical and scar characteristics at left ventricular lead implant site in the context of overall dyssynchrony with cine DENSE predict cardiac resynchronization therapy outcomes.

scientific article published on 16 January 2014

Emergence of Collagen Orientation Heterogeneity in Healing Infarcts and an Agent-Based Model

scientific article

Enhanced regional deformation at the anterior papillary muscle insertion site after chordal transsection.

scientific article published in February 1996

Evaluation of optical flow algorithms for tracking endocardial surfaces on three-dimensional ultrasound data

Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat.

scientific article

Frequency-dependence of myocardial energetics in failing human myocardium as quantified by a new method for the measurement of oxygen consumption in muscle strip preparations

scientific article published on 01 August 1998

Functional implications of myocardial scar structure.

scientific article published in May 1997

Guidelines for Experimental Models of Myocardial Ischemia and Infarction

scientific article published on 12 January 2018

High temporal-resolution phase-contrast MRI demonstrates impaired left-ventricular diastolic relaxation in mice fed a high-fat high-sucrose diet.

scientific article

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

scientific article

Imaging cardiac mechanics: what information do we need to extract from cardiac images?

scientific article published on January 2006

Imaging left-ventricular mechanical activation in heart failure patients using cine DENSE MRI: Validation and implications for cardiac resynchronization therapy

scientific article

Impact of mechanical activation, scar, and electrical timing on cardiac resynchronization therapy response and clinical outcomes

scientific article

Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium

scientific article published on 12 October 2007

Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles

scientific article

Isotonic biaxial loading of fibroblast-populated collagen gels: a versatile, low-cost system for the study of mechanobiology.

scientific article published in June 2002

LV volume quantification via spatiotemporal analysis of real-time 3-D echocardiography

scientific article published on 01 June 2001

Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties.

scientific article published in March 2005

Left ventricular assist device-induced reverse ventricular remodeling.

scientific article

Making better scar: Emerging approaches for modifying mechanical and electrical properties following infarction and ablation

scientific article

Mechanical boundary conditions bias fibroblast invasion in a collagen-fibrin wound model

scientific article

Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis

scientific article published on 15 May 2007

Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts ⬇️

scientific article published on April 10, 2012

Mechanical strain alters gene expression in an in vitro model of hypertrophic scarring

scientific article published in July 2005

Mechanics of cell growth ⬇️

scientific article published on January 31, 2012

Model-based design of mechanical therapies for myocardial infarction

scientific article

Model-based screening of wall motion measures for detection of ischemia in three-dimensional cardiac images

scientific article published in January 2006

Modifying the mechanics of healing infarcts: Is better the enemy of good?

scientific article

Nitrite-induced cross-linking alters remodeling and mechanical properties of collagenous engineered tissues

scientific article published in May 2006

Normalized diastolic properties after left ventricular assist result from reverse remodeling of chamber geometry

scientific article published on 01 September 2001

Parameterization of left ventricular wall motion for detection of regional ischemia

scientific article published in July 2005

Physiological Implications of Myocardial Scar Structure

scientific article

Postprocedure mapping of cardiac resynchronization lead position using standard fluoroscopy systems: implications for the nonresponder with scar

scientific article

Potential strain-dependent mechanisms defining matrix alignment in healing tendons

article

Predicting the Time Course of Ventricular Dilation and Thickening Using a Rapid Compartmental Model

scientific article

Predictions of hypertrophy and its regression in response to pressure overload

scientific article published on 07 December 2019

QUANTITATIVE VALIDATION OF OPTICAL FLOW BASED MYOCARDIAL STRAIN MEASURES USING SONOMICROMETRY

scientific article

Quantification of global and regional left atrial function in paroxysmal atrial fibrillation using CMR derived 4-D wall motion analysis

article published in 2010

Quantitative three-dimensional wall motion analysis predicts ischemic region size and location

scientific article

Region-based endocardium tracking on real-time three-dimensional ultrasound

scientific article published on 29 October 2008

Regional functional depression immediately after ventricular septal defect closure

scientific article published in October 2004

Regional mechanics determine collagen fiber structure in healing myocardial infarcts

scientific article

Remodeling of engineered tissue anisotropy in response to altered loading conditions

scientific article

Role of boundary conditions in determining cell alignment in response to stretch

scientific article published on 17 January 2018

Segmentation of real-time three-dimensional ultrasound for quantification of ventricular function: a clinical study on right and left ventricles

scientific article published in September 2005

Sequencing of mRNA identifies re-expression of fetal splice variants in cardiac hypertrophy.

scientific article

Simultaneous variation of ventricular pacing site and timing with biventricular pacing in acute ventricular failure improves function by interventricular assist

scientific article

Special Issue: Spotlight of the Future of Cardiovascular Engineering Frontiers and Challenges in Cardiovascular Biomechanics

scientific article

Strains at the myotendinous junction predicted by a micromechanical model

scientific article

Structural mechanism for alteration of collagen gel mechanics by glutaraldehyde crosslinking

scientific article

Structure and mechanics of healing myocardial infarcts

scientific article

Surgical reinforcement alters collagen alignment and turnover in healing myocardial infarcts

scientific article published on 20 July 2018

The development of structural and mechanical anisotropy in fibroblast populated collagen gels

scientific article published in October 2005

Theoretical quality assessment of myocardial elastography with in vivo validation

scientific article published in November 2007

Tissue engineering of skeletal muscle.

scientific article published in November 2007

Wall-motion based analysis of global and regional left atrial mechanics

scientific article

Why Is Infarct Expansion Such an Elusive Therapeutic Target?

scientific article

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