List of works - Romano Orru

1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles

scientific article published on 08 September 2008

2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry

scientific article published on 05 February 2016

A Hybrid Solid-State NMR and Electron Microscopy Structure-Determination Protocol for Engineering Advanced para-Crystalline Optical Materials.

scientific article published on 24 January 2017

A microwave-assisted diastereoselective multicomponent reaction to access dibenzo[c,e]azepinones: synthesis and biological evaluation.

scientific article published on 22 March 2011

A multicomponent reaction towards N-(cyanomethyl)amides

scientific article published on 01 June 2009

A multicomponent synthesis of triazinane diones.

scientific article

A novel four-component reaction for the synthesis of functionalised dihydropyrimidinesElectronic supplementary information (ESI) available: 1H and 13C NMR data for 9 and 10. See http://www.rsc.org/suppdata/cc/b3/b308243a

scientific article published on 01 October 2003

A novel three-component reaction toward dihydrooxazolopyridines

scientific article published on 01 January 2009

A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines

scientific article published on 12 July 2007

A universal procedure for the [¹⁸F]trifluoromethylation of aryl iodides and aryl boronic acids with highly improved specific activity.

scientific article

Activity and enantioselectivity of the hydroxynitrile lyase MeHNL in dry organic solvents.

scientific article

Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

scientific article published on 29 August 2016

Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

scientific article published on 25 September 2015

Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet–Spengler-type cyclization sequence

scientific article published on 27 September 2010

Base Metal Catalyzed Isocyanide Insertions

scientific article published on 04 October 2019

Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanide

scientific article published on 12 July 2016

Chemoselective addition of isocyanides to N-tert-butanesulfinimines

scientific article published in 2014

Copper(i) catalyzed oxidative hydrolysis of Ugi 3-component and Ugi-azide reaction products towards 2° α-ketoamides and α-ketotetrazoles.

scientific article

Determination of Controlled Self-Assembly of a Paracrystalline Material by Homology Modelling with Hybrid NMR and TEM.

scientific article published on 28 May 2017

Diastereoselective Multicomponent Synthesis of Dihydropyridones with an Isocyanide Functionality

scientific article published on 01 November 2006

Diastereoselective One-Pot Synthesis of Tetrafunctionalized 2-Imidazolines

scientific article published on 22 May 2014

Efficient C2 functionalisation of 2H-2-imidazolines.

scientific article published on 8 November 2007

Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation.

scientific article published in February 2006

Finding Furfural Hydrogenation Catalysts via Predictive Modelling.

scientific article published on 2 September 2010

Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones

scientific article published on 03 July 2008

Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols.

scientific article published on 15 June 2018

Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions

scientific article published on 01 July 2010

IBX-mediated oxidation of unactivated cyclic amines: application in highly diastereoselective oxidative Ugi-type and aza-Friedel-Crafts reactions.

scientific article published on 14 September 2015

In situ formation of allyl ketones via Hiyama-Nozaki reactions followed by a chromium-mediated Oppenauer oxidation.

scientific article

Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

scientific article published on 08 June 2016

Iodospirocyclization of Tryptamine-Derived Isocyanides: Formal Total Synthesis of Aspidofractinine

scientific article published on 17 October 2018

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.

scientific article published on 04 March 2014

Isocyanoacetate derivatives: synthesis, reactivity, and application.

scientific article published on September 2010

Metal-free one-pot α-carboxylation of primary alcohols.

scientific article

Mild and Practical Indole C2 Allylation by Allylboration of in situ Generated 3-Chloroindolenines

scientific article published on 17 January 2019

Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade

scientific article published on 20 December 2017

Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity ⬇️

scientific article published on June 27, 2011

Multicomponent Synthesis of Dihydropyrimidines and Thiazines

scientific article published on 01 September 2006

Multicomponent Synthesis of N-Heterocyclic Carbene Complexes

Multicomponent reactions - opportunities for the pharmaceutical industry.

scientific article

Multicomponent reactions in drug discovery and medicinal chemistry

scientific article published on 01 November 2018

Multicomponent synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thiones.

scientific article published on 8 February 2012

Multicomponent synthesis of 4-aminophthalazin-1(2H)-ones by palladium-catalyzed isocyanide insertion

scientific article published on 25 June 2013

Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines

scientific article published in 2003

One-Pot Synthesis of N-Substituted β-Amino Alcohols from Aldehydes and Isocyanides

scientific article published on 13 April 2015

Palladium-Catalyzed Construction of Amidines from Arylboronic Acids under Oxidative Conditions.

scientific article

Palladium-catalyzed migratory insertion of isocyanides: an emerging platform in cross-coupling chemistry

scientific article published on 10 June 2013

Palladium-catalyzed synthesis of 2-aminobenzoxazinones by aerobic oxidative coupling of anthranilic acids and isocyanides.

scientific article

Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

scientific article published on 15 November 2011

Recent developments in asymmetric multicomponent reactions.

scientific article published on May 2012

Scope and limitations of an efficient four-component reaction for dihydropyridin-2-ones.

scientific article published in March 2010

Selective formation of 2-imidazolines and 2-substituted oxazoles by using a three-component reaction

scientific article published on 01 January 2008

Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines.

scientific article

Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids.

scientific article published on 8 March 2017

Stereoselective Synthesis of Fused Vinylcyclopropanes by Intramolecular Tsuji-Trost Cascade Cyclization

scientific article published on 12 October 2018

Stereoselective synthesis of N-aryl proline amides by biotransformation–Ugi-Smiles sequence

scientific article published on 19 December 2011

Stereoselective synthesis of fluorinated aminoglycosyl phosphonates

scientific article published on 01 February 2015

Sustainable synthesis of diverse privileged heterocycles by palladium-catalyzed aerobic oxidative isocyanide insertion

scientific article published on 14 November 2012

Sustainable three-component synthesis of isothioureas from isocyanides, thiosulfonates, and amines

scientific article published on 15 September 2014

Synthesis and photophysics of a red-light absorbing supramolecular chromophore system

scientific article published on 25 June 2014

Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines.

scientific article

Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion

scientific article published on 16 January 2020

Synthesis of Imidazolidine-2-(thi)ones via C2-Selective Oxidation and Thionation of 2-Imidazolinium Halides

Synthesis of Secondary Amides from Thiocarbamates

scientific article published on 05 July 2018

Synthesis of conformationally constrained peptidomimetics using multicomponent reactions

scientific article published in January 2009

Synthesis of heterocycles by formal cycloadditions of isocyanides.

scientific article

Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles.

scientific article published in October 2016

The efficient one-pot reaction of up to eight components by the union of multicomponent reactions

scientific article published on 01 January 2009

Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions).

scientific article published on 28 March 2017

Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization

scientific article published on 16 May 2019

Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions.

scientific article

YidC is involved in the biogenesis of the secreted autotransporter hemoglobin protease.

scientific article published on 19 October 2010

List of works by Romano Orru

1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles

2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry

A Hybrid Solid-State NMR and Electron Microscopy Structure-Determination Protocol for Engineering Advanced para-Crystalline Optical Materials.

A microwave-assisted diastereoselective multicomponent reaction to access dibenzo[c,e]azepinones: synthesis and biological evaluation.

A multicomponent reaction towards N-(cyanomethyl)amides

A multicomponent synthesis of triazinane diones.

A novel four-component reaction for the synthesis of functionalised dihydropyrimidinesElectronic supplementary information (ESI) available: 1H and 13C NMR data for 9 and 10. See http://www.rsc.org/suppdata/cc/b3/b308243a

A novel three-component reaction toward dihydrooxazolopyridines

A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines

A universal procedure for the [¹⁸F]trifluoromethylation of aryl iodides and aryl boronic acids with highly improved specific activity.

Activity and enantioselectivity of the hydroxynitrile lyase MeHNL in dry organic solvents.

Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet–Spengler-type cyclization sequence

Base Metal Catalyzed Isocyanide Insertions

Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanide

Chemoselective addition of isocyanides to N-tert-butanesulfinimines

Copper(i) catalyzed oxidative hydrolysis of Ugi 3-component and Ugi-azide reaction products towards 2° α-ketoamides and α-ketotetrazoles.

Determination of Controlled Self-Assembly of a Paracrystalline Material by Homology Modelling with Hybrid NMR and TEM.

Diastereoselective Multicomponent Synthesis of Dihydropyridones with an Isocyanide Functionality

Diastereoselective One-Pot Synthesis of Tetrafunctionalized 2-Imidazolines

Efficient C2 functionalisation of 2H-2-imidazolines.

Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation.

Finding Furfural Hydrogenation Catalysts via Predictive Modelling.

Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones

Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols.

Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions

IBX-mediated oxidation of unactivated cyclic amines: application in highly diastereoselective oxidative Ugi-type and aza-Friedel-Crafts reactions.

In situ formation of allyl ketones via Hiyama-Nozaki reactions followed by a chromium-mediated Oppenauer oxidation.

Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

Iodospirocyclization of Tryptamine-Derived Isocyanides: Formal Total Synthesis of Aspidofractinine

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.

Isocyanoacetate derivatives: synthesis, reactivity, and application.

Metal-free one-pot α-carboxylation of primary alcohols.

Mild and Practical Indole C2 Allylation by Allylboration of in situ Generated 3-Chloroindolenines

Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade

Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity ⬇️

Multicomponent Synthesis of Dihydropyrimidines and Thiazines

Multicomponent Synthesis of N-Heterocyclic Carbene Complexes

Multicomponent reactions - opportunities for the pharmaceutical industry.

Multicomponent reactions in drug discovery and medicinal chemistry

Multicomponent synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thiones.

Multicomponent synthesis of 4-aminophthalazin-1(2H)-ones by palladium-catalyzed isocyanide insertion

Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines

One-Pot Synthesis of N-Substituted β-Amino Alcohols from Aldehydes and Isocyanides

Palladium-Catalyzed Construction of Amidines from Arylboronic Acids under Oxidative Conditions.

Palladium-catalyzed migratory insertion of isocyanides: an emerging platform in cross-coupling chemistry

Palladium-catalyzed synthesis of 2-aminobenzoxazinones by aerobic oxidative coupling of anthranilic acids and isocyanides.

Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

Recent developments in asymmetric multicomponent reactions.

Scope and limitations of an efficient four-component reaction for dihydropyridin-2-ones.

Selective formation of 2-imidazolines and 2-substituted oxazoles by using a three-component reaction

Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines.

Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids.

Stereoselective Synthesis of Fused Vinylcyclopropanes by Intramolecular Tsuji-Trost Cascade Cyclization

Stereoselective synthesis of N-aryl proline amides by biotransformation–Ugi-Smiles sequence

Stereoselective synthesis of fluorinated aminoglycosyl phosphonates

Sustainable synthesis of diverse privileged heterocycles by palladium-catalyzed aerobic oxidative isocyanide insertion

Sustainable three-component synthesis of isothioureas from isocyanides, thiosulfonates, and amines

Synthesis and photophysics of a red-light absorbing supramolecular chromophore system

Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines.

Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion

Synthesis of Imidazolidine-2-(thi)ones via C2-Selective Oxidation and Thionation of 2-Imidazolinium Halides

Synthesis of Secondary Amides from Thiocarbamates

Synthesis of conformationally constrained peptidomimetics using multicomponent reactions

Synthesis of heterocycles by formal cycloadditions of isocyanides.

Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles.

The efficient one-pot reaction of up to eight components by the union of multicomponent reactions

Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions).

Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization

Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions.

YidC is involved in the biogenesis of the secreted autotransporter hemoglobin protease.