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List of works by Wolfdieter Springer

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

scientific article

A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress

scientific article published on 4 October 2005

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

scientific article

Activation of the E3 ubiquitin ligase Parkin.

scientific article

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

scientific article published on 28 July 2018

Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease

scientific article published on 29 July 2019

DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients.

scientific article

Disease relevance of phosphorylated ubiquitin (p-S65-Ub)

scientific article

Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

scientific article

Hexokinases link DJ-1 to the PINK1/parkin pathway

scientific article published on 29 September 2017

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

scientific article

In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling

scientific article published in 2024

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).

scientific article

Mechanisms and models of alpha-synuclein-related neurodegeneration.

scientific article published on September 2006

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy.

scientific article published on 6 November 2017

Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders

scientific article

NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1.

scientific article

Non-radioactive in vitro PINK1 Kinase Assays Using Ubiquitin or Parkin as Substrate

scientific article published on October 2016

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.

scientific article published on January 2017

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?

scientific article

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

scientific article

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.

scientific article published on 4 February 2008

Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans.

scientific article published on 8 April 2010

Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin

scientific article

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

scientific article

Regulation of PINK1-Parkin-mediated mitophagy.

scientific article

Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans

scientific article published in August 2004

Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder

scientific article

Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples

scientific article published on 28 October 2020

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

scientific article published on 3 June 2015

UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination

scientific article

Waldenstrom macroglobulinemia cells devoid of BTKC481S or CXCR4WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.

scientific article

miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).

scientific article published on 26 July 2016

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