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List of works by Jean-Jacques Toulmé

2'-O-methyl-RNA hairpins generate loop-loop complexes and selectively inhibit HIV-1 Tat-mediated transcription

scientific article published on 01 October 2002

A boost for the emerging field of RNA nanotechnology

scientific article published on May 2011

A functional selection of viral genetic elements in cultured cells to identify hepatitis C virus RNA translation inhibitors

scientific article

A phosphorothioate oligonucleotide blocks reverse transcription via an antisense mechanism

scientific article published on 01 March 1994

A spectroscopic probe of stacking interactions between nucleic acid bases and tryptophan residues of proteins ⬇️

scientific article published on December 11, 1979

Absorption and fluorescence studies of the binding of the recA gene product from E. coli to single-stranded and double-stranded DNA. Ionic strength dependence

scientific article published on 01 February 1984

Advances in binder identification and characterisation: the case of oligonucleotide aptamers ⬇️

scientific article published on 08 December 2011

An acridine-linked oligodeoxynucleotide targeted to the common 5' end of trypanosome mRNAs kills cultured parasites.

scientific article published on January 1987

An improved design of the kissing complex-based aptasensor for the detection of adenosine.

scientific article published on 16 June 2015

Anti-HIV activity of steric block oligonucleotides

scientific article published on 01 October 2006

Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression--a review.

scientific article

Antisense effect of oligodeoxynucleotides complementary to the mini-exon sequence of the protozoan parasite Leishmania amazonensis

scientific article published on 01 January 1993

Antisense oligonucleotides targeted to the domain IIId of the hepatitis C virus IRES compete with 40S ribosomal subunit binding and prevent in vitro translation

scientific article

Antisense phosphorothioate oligonucleotides: selective killing of the intracellular parasite Leishmania amazonensis.

scientific article published on August 1994

Apical loop-internal loop interactions: a new RNA-RNA recognition motif identified through in vitro selection against RNA hairpins of the hepatitis C virus mRNA.

scientific article published in May 2002

Aptamer selection by direct microfluidic recovery and surface plasmon resonance evaluation

scientific article

Aptamer-mediated nanoparticle interactions: from oligonucleotide-protein complexes to SELEX screens.

scientific article published on January 2015

Aptamers as imaging agents

scientific article published on 27 September 2010

Aptamers targeting RNA molecules

scientific article published on 01 January 2009

Aptamers: a new class of oligonucleotides in the drug discovery pipeline?

scientific article published on 28 August 2009

Benzoquinazoline derivatives as substitutes for thymine in nucleic acid complexes. Use of fluorescence emission of benzo[g]quinazoline-2,4-(1H,3H)-dione in probing duplex and triplex formation.

scientific article

Bimodal loop-loop interactions increase the affinity of RNA aptamers for HIV-1 RNA structures

scientific article published on 01 February 2006

Binding of oligopyrimidines to the RNA hairpin responsible for the ribosome gag-pol frameshift in HIV-1.

scientific article

Blockage of AM V reverse transcriptase by antisense oligodeoxynucleotides ⬇️

scientific article published on November 12, 1990

Comparative analysis of translation efficiencies of hepatitis C virus 5' untranslated regions among intraindividual quasispecies present in chronic infection: opposite behaviors depending on cell type

scientific article (publication date: November 2000)

Comparative studies of tricyclo-DNA- and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression.

scientific article published on January 2007

Deciphering aromatic oligoamide foldamer-DNA interactions

scientific article published on 01 December 2011

Design of a dual aptamer-based recognition strategy for human matrix metalloproteinase 9 protein by piezoelectric biosensors

scientific article published on 8 August 2015

Determinants of apical loop-internal loop RNA-RNA interactions involving the HCV IRES.

scientific article published on September 2004

ELAKCA: Enzyme-Linked Aptamer Kissing Complex Assay as a Small Molecule Sensing Platform

scientific article published on 11 February 2016

Effect of phosphate ions on the fluorescence of tryptophan derivatives. Implications in fluorescence investigation of protein-nucleic acid complexes

scientific article published on January 1, 1979

Effect of the terminal phosphate derivatization of beta- and alpha-oligodeoxynucleotides on their antisense activity in protein biosynthesis, stability and uptake by eucaryotic cells

scientific article published on 01 May 1992

Electrostatics Explains the Position-Dependent Effect of G⋅U Wobble Base Pairs on the Affinity of RNA Kissing Complexes

scientific article published on 31 July 2017

Encapsidation of RNA–Polyelectrolyte Complexes with Amphiphilic Block Copolymers: Toward a New Self-Assembly Route

scientific article published on 29 November 2012

Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas

scientific article

Fluorescence study of the association between gene 32 protein of bacteriophage T4 and poly(1-N6-ethenoadenylic acid). Evidence for energy transfer.

scientific article published in January 1980

Gel renaturation assay for ribonucleases

scientific article published on 01 January 2001

HAPIscreen, a method for high-throughput aptamer identification.

scientific article

Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA.

scientific article published in March 2005

Improved leishmanicidal effect of phosphorotioate antisense oligonucleotides by LDL-mediated delivery

scientific article published on 01 November 1995

In vitro selection of RNA aptamers derived from a genomic human library against the TAR RNA element of HIV-1.

scientific article

Influence of DNA binding on the formation and reactions of tryptophan and tyrosine radicals in peptides and proteins

scientific article published on 01 February 1984

Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA

scientific article

Interaction of a tryptophan-containing peptide with chromatin core particles. A fluorescence study.

scientific article published on April 1984

LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1.

scientific article published on 14 February 2007

LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1.

scientific article published on 4 June 2004

Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex

scientific article

Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription

scientific article

Mapping of a minimal AU-rich sequence required for lipopolysaccharide-induced binding of a 55-kDa protein on tumor necrosis factor-alpha mRNA.

scientific article published on May 1998

Mechanisms for the recognition of chemically-modified DNA by peptides and proteins

scientific article published on 01 August 1982

Modified oligonucleotides in rabbit reticulocytes: uptake, stability and antisense properties ⬇️

scientific article published on November 1, 1991

NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer

scientific article

New candidates for true antisense

scientific article published on 01 January 2001

New ways of initiating translation in eukaryotes.

scientific article published on December 2001

Nucleic acid aptamers

scientific article published on 01 March 2016

Nucleic acids targeted to drugs: SELEX against a quadruplex ligand

scientific article published on 31 May 2011

RNase H-mediated inhibition of translation by antisense oligodeoxyribonucleotides: use of backbone modification to improve specificity

scientific article published on 01 November 1992

Regulating eukaryotic gene expression with aptamers.

scientific article

Riboswitches based on kissing complexes for the detection of small ligands.

scientific article published on 10 June 2014

SELEX and dynamic combinatorial chemistry interplay for the selection of conjugated RNA aptamers.

scientific article published in November 2006

Selective inhibition of cell-free translation by oligonucleotides targeted to a mRNA hairpin structure.

scientific article

Selective inhibitory DNA aptamers of the human RNase H1 ⬇️

scientific article published on October 1, 2003

Sensitive detection of low levels of ribonuclease H activity by an improved renaturation gel assay.

scientific article

Single-molecule observations of RNA-RNA kissing interactions in a DNA nanostructure

scientific article published on 06 October 2015

Specific regulation of gene expression by antisense, sense and antigene nucleic acids ⬇️

scientific article published on June 21, 1990

Spectroscopic study of the structural changes of scorpion hemocyanin, induced by pH variations and addition of various salts ⬇️

scientific article published on January 1976

Stacking interactions between aromatic amino acids and adenine ring of ATP in zinc mediated ternary complexes ⬇️

scientific article published on April 1, 1978

Surface plasmon resonance investigation of RNA aptamer-RNA ligand interactions.

scientific article

Systematic screening of LNA/2'-O-methyl chimeric derivatives of a TAR RNA aptamer

scientific article published on 30 January 2007

The binding of T4 gene 32 protein to MS2 virus RNA and transfer RNA ⬇️

scientific article published on March 25, 1980

The common 5' terminal sequence on trypanosome mRNAs: a target for anti-messenger oligodeoxynucleotides.

scientific article

Towards the selection of phosphorothioate aptamers optimizing in vitro selection steps with phosphorothioate nucleotides.

scientific article

Use of dynamic combinatorial chemistry for the identification of covalently appended residues that stabilize oligonucleotide complexes.

scientific article

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