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List of works by Nicolas Singewald

129S1/SvImJ mice display impaired contextual fear extinction, enhanced fear incubation and deficit extinction consolidation phenotypes: rescue via pharmacological and non-pharmacological treatments

scholarly article by Nigel Whittle et al published 2011 in BMC Pharmacology

5-HT receptor subtypes involved in the anxiogenic-like action and associated Fos response of acute fluoxetine treatment in rats.

scientific article published on 7 March 2006

A hypomorphic vasopressin allele prevents anxiety-related behavior

scientific article

A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment.

scientific article

A mouse model to study the C-terminal regulation of CaV1.3 L-type calcium channels.

scientific article published on 17 September 2012

Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain

scientific article published on 01 October 2000

Adult neurogenesis in a psychopathological mouse model of trait anxiety and comorbid depression-like behavior: effect of antidepressants.

scientific article published on 12 November 2009

Aldosterone increases earlier than corticosterone in new animal models of depression: is this an early marker?

scientific article published on 14 August 2012

Altered GABA transmission in a mouse model of increased trait anxiety

scientific article

Altered brain activity processing in high-anxiety rodents revealed by challenge paradigms and functional mapping.

scientific article

Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior ⬇️

scientific article published on October 16, 2012

Behavioral and neurobiological effects of deep brain stimulation in a mouse model of high anxiety- and depression-like behavior.

scientific article published on 16 January 2013

Behavioural characterization of prodynorphin knockout mice.

scientific article published on 5 November 2008

Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala

scientific article published on 11 February 2014

Blood pressure changes modify the release rates of catecholamines in the intermediate nucleus of the solitary tract.

scientific article published in February 1992

Ca1.3 L-type calcium channels modulate depression-like behavior in mice independent of deaf phenotype

scientific article published on 12 November 2009

Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I.

scientific article published on 28 August 2006

Catecholamine release in the locus coeruleus is modified by experimentally induced changes in haemodynamics.

scientific article published in January 1993

Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain

scientific article

Changes in brain protein expression are linked to magnesium restriction-induced depression-like behavior.

scientific article published on 11 February 2011

Chronic treatment with a selective neurokinin-1 receptor antagonist in a mouse model of trait anxiety and depression: focus on behaviour and neuropeptidergic mechanisms.

scientific article

Circadian abnormalities in a mouse model of high trait anxiety and depression

scientific article

Combined Neuropeptide S and D-Cycloserine Augmentation Prevents the Return of Fear in Extinction-Impaired Rodents: Advantage of Dual versus Single Drug Approaches.

scientific article

Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system

scientific article published on 01 November 2008

Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior.

scientific article published on 13 May 2008

Corticotropin-releasing factor modulates basal and stress-induced excitatory amino acid release in the locus coeruleus of conscious rats.

scientific article published in February 1996

Decreased social interaction in aged rats may not reflect changes in anxiety-related behaviour

scientific article

Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model ⬇️

scientific article published on June 18, 2012

Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice.

scientific article published in November 2007

Dietary magnesium restriction reduces amygdala-hypothalamic GluN1 receptor complex levels in mice

scientific article

Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology.

scientific article

Different fear states engage distinct networks within the intercalated cell clusters of the amygdala.

scientific article published in March 2011

Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice

scientific article published on 11 April 2019

Differential stress-induced neuronal activation patterns in mouse lines selectively bred for high, normal or low anxiety

scientific article

Disturbances in blood pressure homeostasis modify GABA release in the locus coeruleus

scientific article published on 01 September 1994

Durable fear memories require PSD-95

scientific article published on 31 March 2015

Durable fear memories require PSD-95.

scientific article published on 16 December 2014

Dysregulation of select ATP-dependent chromatin remodeling factors in high trait anxiety

scientific article

Effects of disrupted ghrelin receptor function on fear processing, anxiety and saccharin preference in mice

scientific article published on 06 September 2019

Effects of ghrelin receptor activation on forebrain dopamine release, conditioned fear and fear extinction in C57BL/6J mice

scientific article published on 03 March 2020

Effects of neuroactive compounds, noxious and cardiovascular stimuli on the release of amino acids in the rat locus coeruleus.

scientific article published in October 1994

Endogenous dynorphin in emotional control and stress response.

scientific article published on 12 November 2009

Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions

scientific article (publication date: 28 February 2011)

Enhanced fear expression in a psychphathological mouse model of trait anxiety: pharmacological interventions.

scientific article published on 16 November 2010

Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction.

scientific article published on 06 December 2016

Epigenetic Mechanisms Within the Cingulate Cortex Regulate Innate Anxiety-Like Behavior

scientific article published on 01 April 2019

Erratum to: Dietary magnesium restriction reduces amygdala-hypothalamic GluN1 receptor complex levels in mice

scientific article published in July 2015

Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain.

scientific article published in June 2004

Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in down's syndrome and Alzheimer's Disease

article

Exploring the role of neuropeptide S in the regulation of arousal: a functional anatomical study

scientific article published on 13 October 2015

Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high- and low-anxiety dams rats during maternal aggression: regulation by oxytocin.

scientific article published in August 2007

Fear learning induces structural and functional plasticity at GABAergic synapses in the basolateral amygdala.

scientific article published on 5 September 2011

Fear learning triggers structural changes at GABAergic synapses in the basal amygdala.

scientific article published on 16 November 2010

Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development

scientific article published on 12 November 2007

Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior

scientific article

GABA selectively controls the secretory activity of oxytocin neurons in the rat supraoptic nucleus.

scientific article published on February 2004

GPR39 Zn(2+)-sensing receptor: a new target in antidepressant development?

scientific article

Genetic functional inactivation of neuronal nitric oxide synthase affects stress-related Fos expression in specific brain regions.

scientific article published in June 2004

Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes.

scientific article published on 15 February 2012

HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?

scientific article

High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats

scientific article

Histone deacetylase inhibitors, glutamatergic drugs and deep brain stimulation rescue resistance to fear extinction in a genetic mouse model.

scientific article published on 17 September 2012

Hypothalamic and hippocampal release of serotonin in rats bred for hyper- or hypo-anxiety.

scientific article published on December 2002

Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors

scientific article

Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain

scientific article

Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain

scientific article published on August 2008

Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety.

scientific article published on September 2004

In vivo release of catecholamines in the locus coeruleus.

scientific article published in October 1994

In vivo release patterns and cardiovascular properties of inhibitory and excitatory amino acids in the hypothalamus

scientific article published on 01 March 1995

Increased cocaine-induced conditioned place preference during periadolescence in maternally separated male BALB/c mice: the role of cortical BDNF, microRNA-212, and MeCP2.

scientific article published on 9 July 2016

Increased conditioned place preference for cocaine in high anxiety related behavior (HAB) mice is associated with an increased activation in the accumbens corridor

scientific article

Increased in vivo release of neuropeptide S in the amygdala of freely moving rats after local depolarisation and emotional stress.

scientific article published on 23 August 2011

Increased novelty-induced motor activity and reduced depression-like behavior in NPY Y4 receptor knockout mice.

scientific article

Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice

scientific article

Individual contribution of metabotropic glutamate receptor (mGlu) 2 and 3 to c-Fos expression pattern evoked by mGlu2/3 antagonism.

scientific article published on 24 September 2008

Individual differences in recovery from traumatic fear

scientific article

Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs

scientific article (publication date: 15 February 2003)

Influence of estrous cycle on explorative behaviour of wild-type and prodynorphin knockout mice.

scientific article published on 5 November 2008

Influence of excitatory amino acids on basal and sensory stimuli-induced release of 5-HT in the locus coeruleus.

scientific article

Inhibition of catecholamine (noradrenaline, dopamine) release in the locus coeruleus and the hypothalamus by baroreceptor activation: identification of the involved baroreceptors

scientific article published on 01 September 1995

Inhibitory function of the dorsomedial hypothalamic nucleus on the hypothalamic-pituitary-adrenal axis response to an emotional stressor but not immune challenge.

scientific article published on January 2013

Involvement of catecholaminergic neurones of the nucleus of the solitary tract (NTS) in blood pressure regulation

scientific article published on 01 January 1991

Ionic and haemodynamic changes influence the release of the excitatory amino acid glutamate in the posterior hypothalamus

scientific article published on 01 December 1995

Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels

scientific article

Loss of Nogo receptor homolog NgR2 alters spine morphology of CA1 neurons and emotionality in adult mice.

scientific article

Magnesium-deficient diet alters depression- and anxiety-related behavior in mice--influence of desipramine and Hypericum perforatum extract.

scientific article published in December 2004

MicroRNA-Mediated Rescue of Fear Extinction Memory by miR-144-3p in Extinction-Impaired Mice.

scientific article

Modulation of magnesium deficiency-induced anxiety and HPA axis dysregulation by therapeutic drug treatment.

scientific article

Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice

scientific article

Neuroanatomical substrates involved in the anxiogenic-like effect of acute fluoxetine treatment.

scientific article published in December 2002

Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry

scientific article published in January 2000

Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats.

scientific article published on April 2004

Neurobiological correlates of successful deep brain stimulation in a mouse model of high trait affect.

scientific article

Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline

scientific article published on 30 July 2020

Neuronal circuits of fear extinction

scientific article published on 11 February 2010

Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression.

scientific article published on 9 May 2011

Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

scientific article published on 27 August 2019

On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

scientific article published on 19 October 2020

Perinatal asphyxia exerts lifelong effects on neuronal responsiveness to stress in specific brain regions in the rat.

scientific article published in September 2003

Peripheral chemoreceptor activation enhances 5-hydroxytryptamine release in the locus coeruleus of conscious rats

scientific article published on 01 July 2000

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

scientific article

Pharmacophore Modeling, Virtual Screening, and in Vitro Testing Reveal Haloperidol, Eprazinone, and Fenbutrazate as Neurokinin Receptors Ligands

scientific article published on 12 June 2014

Polyamines in frontal cortex of patients with Down syndrome and Alzheimer disease

scientific article published in March 1996

Potential of microRNAs as novel targets in the alleviation of pathological fear

scientific article published on 13 October 2017

Prefrontal inputs to the amygdala instruct fear extinction memory formation.

scientific article

Prefrontal single-unit firing associated with deficient extinction in mice.

scientific article

Reduced Anxiety-Like Behavior and Altered Hippocampal Morphology in Female p75NTR(exon IV-/-) Mice

scientific article published on June 2016

Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice.

scientific article

Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress

scientific article published on 01 December 1995

Release of neurotransmitters in the locus coeruleus.

scientific article published in October 1998

Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids.

scientific article published in February 2005

Release of serotonin in the locus coeruleus of normotensive and spontaneously hypertensive rats (SHR).

scientific article

Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis.

scientific article published in October 2002

Repetitive transcranial magnetic stimulation increases the release of dopamine in the nucleus accumbens shell of morphine-sensitized rats during abstinence.

scientific article

Rodent models of impaired fear extinction

scientific article published on 31 October 2018

Role for Chromatin Remodeling Factor Chd1 in Learning and Memory

scientific article published on 23 January 2019

Role of nitric oxide in the stress-induced release of serotonin in the locus coeruleus.

scientific article

Role of voltage-gated L-type Ca2+ channel isoforms for brain function.

scientific article published in November 2006

Satb2 determines miRNA expression and long-term memory in the adult central nervous system.

scientific article

Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.

scientific article published on March 2015

Septal urocortin 3 modulates stress-coping behaviour but not hypothalamic-pituitary-adrenal axis activity during forced swimming.

scientific article

Serotonin (5-HT) in brains of adult patients with Down syndrome.

scientific article published in January 1999

Serotonin outflow in the hypothalamus of conscious rats: origin and possible involvement in cardiovascular control.

scientific article published in December 1995

Serotonin(1A)-receptor-dependent signaling proteins in mouse hippocampus.

scientific article published on 14 July 2009

Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear

scientific article

Sinoaortic denervation abolishes blood pressure-induced GABA release in the locus coeruleus of conscious rats.

scientific article published on 17 October 2005

Social interaction reward in rats has anti-stress effects

scientific article published on 26 January 2020

Stereoselective and region-specific induction of immediate early gene expression in rat parietal cortex by blockade of neurokinin 1 receptors

scientific article published on 4 October 2005

Stress-induced release of substance P in the locus coeruleus modulates cortical noradrenaline release

scientific article published on 19 September 2007

Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning

scientific article published on 19 September 2019

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

scientific article

Sub-chronic dietary tryptophan depletion – An animal model of depression with improved face and good construct validity

scientific article published in February 2012

Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation.

scientific article

Substance P in the medial amygdala: emotional stress-sensitive release and modulation of anxiety-related behavior in rats

scholarly article

Tachykinin receptors as therapeutic targets in stress-related disorders.

scientific article published on January 2009

Temporal factors in the extinction of fear in inbred mouse strains differing in extinction efficacy.

scientific article published on 05 July 2013

The L-type calcium channel Cav1.3 is required for proper hippocampal neurogenesis and cognitive functions

scientific article published on 3 October 2015

The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system.

scientific article published on 21 August 2006

The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression.

scientific article

The clinical implications of mouse models of enhanced anxiety.

scientific article

The galanin system in depression and antidepressant treatment: focus on the locus coeruleus

The release of catecholamines in hypothalamus and locus coeruleus is modulated by peripheral chemoreceptors

scientific article published on 01 October 1999

The release of inhibitory amino acids in the hypothalamus is tonically modified by impulses from aortic baroreceptors as a consequence of blood pressure fluctuations.

scientific article published in September 1997

Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion.

scientific article published in August 2002

Vasopressin selectively modulates the release of taurine within the septum of the rat brain

scientific article published on 01 December 1999

Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice

scientific article published in January 2006

Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in mice

scientific article published on 31 October 2008

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