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List of works by Silvia Giordano

A long term, non-tumorigenic rat hepatocyte cell line and its malignant counterpart, as tools to study hepatocarcinogenesis

scientific article published on February 2017

A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine

scientific article published on 21 March 2022

A point mutation in the MET oncogene abrogates metastasis without affecting transformation.

scientific article

Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity

scientific article

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition.

scientific article

Activation of RAS family members confers resistance to ROS1 targeting drugs.

scientific article

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

scientific article

BRAF and MEK inhibitors increase PD1-positive melanoma cells leading to a potential lymphocyte-independent synergism with anti-PD1 antibody.

scientific article published on 12 April 2018

Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study.

scientific article published on 5 December 2017

By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy.

scientific article

C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells

scientific article published on 01 April 1998

C-terminal truncated forms of Met, the hepatocyte growth factor receptor

scientific article published on December 1991

CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes

scientific article (publication date: March 2003)

Cancer therapy: can the challenge be MET?

scientific article

Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

scientific article

Cell-Autonomous and Non–Cell-Autonomous Mechanisms of HGF/MET–Driven Resistance to Targeted Therapies: From Basic Research to a Clinical Perspective ⬇️

scientific article published on July 30, 2013

Clinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas

scientific article published on 21 May 2020

Clustered protocadherins methylation alterations in cancer

scientific article published on 09 July 2019

Colorectal cancer early methylation alterations affect the crosstalk between cell and surrounding environment, tracing a biomarker signature specific for this tumor.

scientific article published on 15 March 2018

Control of invasive growth by the HGF receptor family ⬇️

scientific article published on November 1, 1997

Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis

scientific article published on 03 October 2015

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

scientific article published on 7 May 2007

Differential requirement of the last C-terminal tail of Met receptor for cell transformation and invasiveness.

scientific article published on September 2001

Downregulating Neuropilin-2 triggers a novel mechanism enabling EGFR-dependent resistance to oncogene-targeted therapies

scientific article published on 11 December 2017

Drug development of MET inhibitors: targeting oncogene addiction and expedience

scientific article

Dual MET/EGFR therapy leads to complete response and resistance prevention in a MET-amplified gastroesophageal xenopatient cohort

scientific article published on 15 August 2016

Editorial: Metabolism As a Therapeutic Target.

scientific article published on 9 November 2017

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

scientific article published on 28 June 2010

ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells.

scientific article published on February 2003

From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage.

scientific article published on January 2008

Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling

scientific article (publication date: 11 January 2001)

HER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and are sensitive to the multitargeted kinase inhibitor sorafenib

scientific article published on 9 December 2010

HGF/MET signalling protects Plasmodium-infected host cells from apoptosis.

scientific article

HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells

scientific article

Hepatocyte growth factor and its receptor are required for malaria infection

scientific article published on 12 October 2003

Hepatocyte growth factor is a regulator of monocyte-macrophage function

scientific article published on 01 January 2001

How Can Gastric Cancer Molecular Profiling Guide Future Therapies?

scientific article published on 31 May 2016

Human ASH-1 promotes neuroendocrine differentiation in androgen deprivation conditions and interferes with androgen responsiveness in prostate cancer cells.

scientific article published on 08 May 2013

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

scientific article (publication date: April 2003)

Increase of MET gene copy number confers resistance to a monovalent MET antibody and establishes drug dependence

scientific article

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

scientific article published on 30 August 2018

Interplay between scatter factor receptors and B plexins controls invasive growth

scientific article

Invasive growth: A two-way street for semaphorin signalling

scientific article published on 01 December 2004

Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene.

scientific article published on December 1992

Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats

scientific article

MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors

scientific article published on 14 September 2010

MET overexpression turns human primary osteoblasts into osteosarcomas.

scientific article published on May 2006

MET receptor is overexpressed but not mutated in oral squamous cell carcinomas.

scientific article published in December 2001

Met as a therapeutic target in HCC: facts and hopes.

scientific article

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

scientific article published on 7 April 2016

MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer

scientific article published on 16 December 2011

MiRNAs as new master players.

scientific article published on July 2009

MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).

scientific article published on 18 November 2013

MicroRNAs impair MET-mediated invasive growth

scientific article

MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?

scientific article published on 26 December 2012

Molecular cancer therapy: can our expectation be MET?

scientific article published on 04 March 2008

Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy

scientific article

Negative receptor signalling

scientific article

Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies

scientific article published on 13 August 2018

Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases

scientific article published on 12 October 2020

Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis.

scientific article published on 22 April 2015

Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

scientific article published on 08 December 2009

Only a subset of Met-activated pathways are required to sustain oncogene addiction

scientific article

Patient-Derived Orthotopic Xenograft models in gastric cancer: a systematic review

scientific article published on 06 April 2020

Plexin-B3 is a functional receptor for semaphorin 5A.

scientific article published on 25 June 2004

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration

scientific article published on 29 April 2020

Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS)

scientific article published on 6 February 2006

Proteins phosphorylated on tyrosine as markers of human tumor cell lines

scientific article published on 01 April 1987

Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells

scientific article published on 29 April 2004

Reply to: "YAP in tumorigenesis: Friend or foe?"

scientific article published on 17 February 2015

Resistance to targeted therapies: a role for microRNAs?

scientific article published on 03 September 2013

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.

scientific article published on 22 March 2018

Sema4D induces angiogenesis through Met recruitment by Plexin B1

scientific article

Semaphorin pathways orchestrate osteogenesis

scientific article published on 01 June 2006

Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression.

scientific article published on 16 January 2012

Silencing the MET oncogene leads to regression of experimental tumors and metastases

scientific article published on 06 August 2007

Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas

scientific article published on 01 March 2000

Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

scientific article

TGFalpha expression impairs Trastuzumab-induced HER2 downregulation

scientific article published in April 2005

Targeted therapies for gastric cancer: failures and hopes from clinical trials

scientific article published on 26 January 2017

Targeted therapies in cancer and mechanisms of resistance

scientific article published on 01 July 2014

Targeting MET: why, where and how? ⬇️

scientific article published on June 21, 2013

Targeting Plasmodium host cells: survival within hepatocytes

scientific article published in October 2004

The Dual Roles of NRF2 in Cancer.

scientific article published on 2 June 2016

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

scientific article (publication date: 14 March 2002)

The landscape of d16HER2 splice variant expression across HER2-positive cancers

scientific article published on 05 March 2019

The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival

scientific article

The semaphorin 4D receptor controls invasive growth by coupling with Met

scientific article (publication date: September 2002)

Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages

scientific article published on 16 June 2008

Tumorigenic and metastatic activity of human thyroid cancer stem cells

scientific article published on 19 October 2010

YAP activation is an early event and a potential therapeutic target in liver cancer development.

scientific article

YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC.

scientific article published on 11 November 2017

Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.

scientific article

miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling.

scientific article published in September 2018

miRs*: Innocent bystanders only?

scientific article published on 24 August 2016

p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line

scientific article published on August 1988

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