List of works - Miguel Navarro

A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei

scientific article published in Nature

Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48.

scientific article published on 12 March 2018

Autophagy in protists.

scientific article published on February 2011

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

scientific article

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.

scientific article published on 12 September 2016

Cohesin regulates VSG monoallelic expression in trypanosomes

scientific article published on July 2009

Defeating Leishmania resistance to Miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: A proof of mechanism for trypanosomatid chemotherapy

Diamine and aminoalcohol derivatives active against Trypanosoma brucei

scientific article published on 06 November 2011

Dynamics and size polymorphisms of minichromosomes in Leishmania major LV-561 cloned lines

scientific article published on October 1, 1992

Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness

scientific article published on 21 May 2014

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents

scientific article published on 08 February 2019

From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.

scientific article

Glossina palpalis palpalis populations from Equatorial Guinea belong to distinct allopatric clades

scientific article published on 17 January 2014

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

scientific article

Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign

scientific article (publication date: October 2014)

Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

scientific article published on 17 January 2016

In situ analysis of a variant surface glycoprotein expression-site promoter region in Trypanosoma brucei

scientific article published on 01 July 1998

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

scientific article

Inverted repeat structure and homologous sequences in the LD1 amplicons of Leishmania spp

scientific article published on 01 November 1994

Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei.

scientific article

Location in the source chromosome of the 180-kb minichromosome of Leishmania major and characterization of the novel junction.

scientific article

Molecular evidence of a Trypanosoma brucei gambiense sylvatic cycle in the human african trypanosomiasis foci of Equatorial Guinea

scientific article published on 24 July 2015

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions

scientific article (publication date: 2012)

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.

scientific article

New tubulins in protozoal parasites.

scientific article published in April 2000

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei

scientific article published on 11 July 2017

Nuclear architecture underlying gene expression in Trypanosoma brucei

scientific article published on 4 May 2007

Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei

scientific article

RNA pol II subunit RPB7 is required for RNA pol I-mediated transcription in Trypanosoma brucei

scientific article

Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation

scholarly article

Role of RPB7 in RNA pol I transcription in Trypanosoma brucei.

scientific article

SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes

scientific article published on 06 November 2019

SUMOylation by the E3 ligase TbSIZ1/PIAS1 positively regulates VSG expression in Trypanosoma brucei.

scientific article

Target of rapamycin (TOR) kinase in Trypanosoma brucei: an extended family.

scientific article published in August 2013

Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei

scientific article

The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei

scientific article published on October 2016

The molecular karyotype of the megabase chromosomes of Trypanosoma brucei stock 427.

scientific article published in December 2000

The protozoan nucleus

scientific article published on 12 May 2016

The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing

scientific article

Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei

scientific article

Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity

scientific article

Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/inactivation and chromatin remodeling of expression sites

scientific article

Trypanosome TOR as a major regulator of cell growth and autophagy

scientific article

Trypanosome TOR complex 2 functions in cytokinesis

scientific article published on 9 March 2009

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.

scientific article

List of works by Miguel Navarro

A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei

Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48.

Autophagy in protists.

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.

Cohesin regulates VSG monoallelic expression in trypanosomes

Defeating Leishmania resistance to Miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: A proof of mechanism for trypanosomatid chemotherapy

Diamine and aminoalcohol derivatives active against Trypanosoma brucei

Dynamics and size polymorphisms of minichromosomes in Leishmania major LV-561 cloned lines

Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents

From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.

Glossina palpalis palpalis populations from Equatorial Guinea belong to distinct allopatric clades

Guidelines for the use and interpretation of assays for monitoring autophagy

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign

Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

In situ analysis of a variant surface glycoprotein expression-site promoter region in Trypanosoma brucei

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

Inverted repeat structure and homologous sequences in the LD1 amplicons of Leishmania spp

Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei.

Location in the source chromosome of the 180-kb minichromosome of Leishmania major and characterization of the novel junction.

Molecular evidence of a Trypanosoma brucei gambiense sylvatic cycle in the human african trypanosomiasis foci of Equatorial Guinea

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.

New tubulins in protozoal parasites.

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei

Nuclear architecture underlying gene expression in Trypanosoma brucei

Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei

RNA pol II subunit RPB7 is required for RNA pol I-mediated transcription in Trypanosoma brucei

Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation

Role of RPB7 in RNA pol I transcription in Trypanosoma brucei.

SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes

SUMOylation by the E3 ligase TbSIZ1/PIAS1 positively regulates VSG expression in Trypanosoma brucei.

Target of rapamycin (TOR) kinase in Trypanosoma brucei: an extended family.

Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei

The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei

The molecular karyotype of the megabase chromosomes of Trypanosoma brucei stock 427.

The protozoan nucleus

The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing

Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei

Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity

Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/inactivation and chromatin remodeling of expression sites

Trypanosome TOR as a major regulator of cell growth and autophagy

Trypanosome TOR complex 2 functions in cytokinesis

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.