List of works - Nicolas Cenac

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D

scientific article published on 18 December 2018

A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice.

scientific article published on 6 November 2015

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.

scientific article

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

scientific article published on 03 June 2013

Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS.

scientific article published on 15 July 2014

Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response

scientific article published on 15 September 2015

Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition

scientific article published on 8 June 2009

Apelin targets gut contraction to control glucose metabolism via the brain

scientific article

Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis

scientific article published on 25 September 2020

Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome

scientific article published on 19 August 2011

Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism

scientific article published in September 2003

Colonic luminal proteases activate colonocyte proteinase-activated receptor-2 and regulate paracellular permeability in mice.

scientific article published on January 2007

Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures.

scientific article published on 14 July 2015

Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.

scientific article

Development, plasticity and modulation of visceral afferents

scientific article

Different activation signals induce distinct mast cell degranulation strategies

scientific article

Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice

scientific article published on 07 October 2019

Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice

scientific article

Epithelial expression and function of trypsin-3 in irritable bowel syndrome

scientific article

FPR2: A Novel Promising Target for the Treatment of Influenza

scientific article published on 5 September 2017

Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections

scientific article published on 30 March 2016

Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917.

scientific article published on 3 November 2017

In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.

scientific article published on 5 August 2016

Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2

scientific article

Inhibition of sensory afferents activation and visceral pain by a brominated algal diterpene.

scientific article

Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response.

scientific article published on 29 January 2010

Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons

scientific article published on 5 October 2007

LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites

scientific article published on 15 June 2013

Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain.

scientific article

Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis

scientific article published in January 2011

Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity

scientific article published on 8 May 2009

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.

scientific article

PAR(2) and temporomandibular joint inflammation in the rat.

scientific article published on 22 July 2010

PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways

scientific article

PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells.

scientific article published on 16 June 2016

PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.

scientific article

Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine

scientific article

Polyunsaturated fatty acid metabolites: biosynthesis in Leishmania and role in parasite/host interaction

scientific article published on 09 January 2019

Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity

scientific article published in April 2010

Protease-Activated Receptor 1 is Implicated in Irritable Bowel Syndrome Mediators-Induced Signalling to Thoracic Human Sensory Neurons

scientific article published on 15 March 2018

Protease-Activated Receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation.

scientific article published on 7 September 2017

Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

scientific article published on 23 November 2006

Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation

scientific journal article

Protease-activated receptors as therapeutic targets in visceral pain.

scientific article published on December 2013

Proteases and protease-activated receptors (PARs): novel signals for pain.

scientific article

Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents

scientific article

Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

scientific article published on 15 December 2014

Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response

scientific article published in September 2005

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

scientific article published on 22 April 2015

Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue–Derived Stromal Vascular Cells

article

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice

scientific article published on 16 August 2016

Role for protease activity in visceral pain in irritable bowel syndrome

scientific article

Role of transient receptor potential vanilloid 4 in rat joint inflammation

scientific article published on 19 December 2011

Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine

scientific article published on 7 November 2011

Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice

scientific article published on September 2003

T-lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice

scientific article published on 19 April 2017

Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT).

scientific article

The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease

scientific article published on 3 May 2016

Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.

scientific article

Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice

scientific article published on October 2010

Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms

scientific article published on 10 May 2008

List of works by Nicolas Cenac

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D

A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice.

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS.

Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response

Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition

Apelin targets gut contraction to control glucose metabolism via the brain

Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis

Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome

Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism

Colonic luminal proteases activate colonocyte proteinase-activated receptor-2 and regulate paracellular permeability in mice.

Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures.

Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.

Development, plasticity and modulation of visceral afferents

Different activation signals induce distinct mast cell degranulation strategies

Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice

Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice

Epithelial expression and function of trypsin-3 in irritable bowel syndrome

FPR2: A Novel Promising Target for the Treatment of Influenza

Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections

Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917.

In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.

Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2

Inhibition of sensory afferents activation and visceral pain by a brominated algal diterpene.

Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response.

Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons

LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites

Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain.

Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis

Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.

PAR(2) and temporomandibular joint inflammation in the rat.

PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways

PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells.

PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.

Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine

Polyunsaturated fatty acid metabolites: biosynthesis in Leishmania and role in parasite/host interaction

Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity

Protease-Activated Receptor 1 is Implicated in Irritable Bowel Syndrome Mediators-Induced Signalling to Thoracic Human Sensory Neurons

Protease-Activated Receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation.

Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation

Protease-activated receptors as therapeutic targets in visceral pain.

Proteases and protease-activated receptors (PARs): novel signals for pain.

Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents

Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue–Derived Stromal Vascular Cells

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice

Role for protease activity in visceral pain in irritable bowel syndrome

Role of transient receptor potential vanilloid 4 in rat joint inflammation

Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine

Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice

T-lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice

Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT).

The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease

Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.

Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice

Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms