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List of works by Rachel L. Graham

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease ⬇️

scientific article

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant

scientific article

A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques

scientific article published in Scientific Reports

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

scientific article (preprint)

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

scientific article published on 06 April 2020

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing

scientific article

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

scientific article published in September 2019

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

scientific article

Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus

scientific article published on 30 April 2013

Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication

scientific article

Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines

scholarly article by Vineet D. Menachery published in September 2018

Combination attenuation offers strategy for live-attenuated coronavirus vaccines

scholarly article published 28 April 2018

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

scientific article

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity

scientific article

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses

scientific article

Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing

scientific article

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

scientific article published on 22 August 2017

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication

scientific article published on 01 January 2006

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

scientific article published on 15 November 2017

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis

scientific article published on 28 March 2007

Novel modulators of p53-signaling encoded by unknown genes of emerging viruses

scientific article published on 07 January 2021

Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication

scientific article published on 18 July 2007

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

scientific article published on 07 July 2020

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

scientific article published on 28 April 2020

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

scientific article

Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice

scientific article published on March 2005

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

scholarly article

The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication

scientific article published on January 2006

The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication

scientific article

Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection

scientific article published on 14 February 2020

Trypsin treatment unlocks barrier for zoonotic coronaviruses infection

scientific article published on 17 September 2019

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