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List of works by Jean-Emmanuel Hugonnet

Activation of the L,D-transpeptidation peptidoglycan cross-linking pathway by a metallo-D,D-carboxypeptidase in Enterococcus faecium.

scientific article published on 16 December 2009

Acyl acceptor recognition by Enterococcus faecium L,D-transpeptidase Ldtfm

scientific article

Aslfm, the D-aspartate ligase responsible for the addition of D-aspartic acid onto the peptidoglycan precursor of Enterococcus faecium.

scientific article

Characterization of CrgA, a new partner of the Mycobacterium tuberculosis peptidoglycan polymerization complexes

scientific journal article

Characterization of broad-spectrum Mycobacterium abscessus class A β-lactamase.

scientific article published on 16 October 2013

Cloning, purification, crystallization and preliminary crystallographic analysis of a penicillin-binding protein homologue from Pyrococcus abyssi.

scientific article published on 25 October 2005

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

scientific article published on 18 May 2015

Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins

article published in the Proceedings of the National Academy of Sciences of the United States of America

Crystal Structure of a Novel β-Lactam-insensitive Peptidoglycan Transpeptidase

scientific article published on 23 March 2006

Crystallization and preliminary X-ray analysis of Weissella viridescens FemX UDP-MurNAc-pentapeptide:l-alanine ligase.

scientific article

Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).

scientific article

Dynamics Induced by β-Lactam Antibiotics in the Active Site of Bacillus subtilis l,d-Transpeptidase ⬇️

scientific article published on May 9, 2012

Efficient combination of clavulanate and beta-lactam antibiotics against extensively drug-resistant M. tuberculosis

scientific article published in August 2009

Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

scientific article published on 21 October 2016

Fighting resistant tuberculosis with old compounds: the carbapenem paradigm

scientific article published on 01 November 2011

Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif

scientific article

Idiosyncratic features in tRNAs participating in bacterial cell wall synthesis

scientific article

Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

scientific article

In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems

scientific article published on 16 September 2013

Inactivation of Mycobacterium tuberculosis l , d -Transpeptidase Ldt Mt1 by Carbapenems and Cephalosporins ⬇️

scientific article published on May 21, 2012

Inhibition of β-lactamases of mycobacteria by avibactam and clavulanate

scientific article published on 30 December 2016

Kinetic Analysis of Enterococcus faecium l , d -Transpeptidase Inactivation by Carbapenems ⬇️

scientific article published on March 26, 2012

Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity

scientific article (publication date: 2013)

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

scientific article

Methicillin-Susceptible, Vancomycin-Resistant Staphylococcus aureus, Brazil

scientific article

Mutation landscape of acquired cross-resistance to glycopeptide and β-lactam antibiotics in Enterococcus faecium

scientific article

Peptidoglycan cross-linking in glycopeptide-resistant Actinomycetales

scientific article published on 06 January 2014

Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic

scientific article

Reversible inactivation of a peptidoglycan transpeptidase by a β-lactam antibiotic mediated by β-lactam-ring recyclization in the enzyme active site.

scientific article published on 22 August 2017

Role of class A penicillin-binding proteins in PBP5-mediated beta-lactam resistance in Enterococcus faecalis

scientific article

Routes of Synthesis of Carbapenems for Optimizing Both the Inactivation of L,D-Transpeptidase LdtMt1 of Mycobacterium tuberculosis and the Stability toward Hydrolysis by β-Lactamase BlaC.

scientific article published on 18 March 2016

Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes.

scientific article

Structure of Enterococcus faecium l , d -Transpeptidase Acylated by Ertapenem Provides Insight into the Inactivation Mechanism

scientific article

Synthesis of the L-alanyl-L-alanine cross-bridge of Enterococcus faecalis peptidoglycan

scientific article published on 24 September 2002

The CroRS two-component regulatory system is required for intrinsic beta-lactam resistance in Enterococcus faecalis.

scientific article

Tryptophan Fluorescence Quenching in β-Lactam-Interacting Proteins Is Modulated by the Structure of Intermediates and Final Products of the Acylation Reaction

scientific article published on 14 May 2019

Unexpected Inhibition of Peptidoglycan LD-Transpeptidase fromEnterococcus faeciumby the β-Lactam Imipenem

scientific article published in Journal of Biological Chemistry

β-Lactamase inhibition by avibactam in Mycobacterium abscessus

scientific article published on 18 December 2014

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