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List of works by Tobias Engel

A calcium-sensitive feed-forward loop regulating the expression of the ATP-gated purinergic P2X7 receptor via specificity protein 1 and microRNA-22.

scientific article published on 10 November 2016

A mouse model to study tau pathology related with tau phosphorylation and assembly

scientific article published on 23 March 2007

ATPergic signalling during seizures and epilepsy

scientific article

Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus

scientific article published on 30 May 2014

Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures

scientific article published on 23 April 2019

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor

scientific article published on 30 July 2010

BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus.

scientific article

Bax regulates neuronal Ca2+ homeostasis.

scientific article

Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

scientific article published on 31 December 2010

Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice.

scientific article published on 17 August 2012

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death.

scientific article

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

scientific journal article

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures

scientific article published on 29 January 2013

Characterization of Alzheimer paired helical filaments by electron microscopy

scientific article

Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse

scientific article published on 07 September 2020

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

scientific article published on 24 October 2006

Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y1 Receptor in Experimental Epilepsy

scientific article published on 02 May 2019

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.

scientific article

Contribution of apoptosis-associated signaling pathways to epileptogenesis: lessons from Bcl-2 family knockouts

scientific article published on 16 July 2013

Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration

scientific article published on 27 July 2005

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

scientific article (publication date: 2016)

Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus.

scientific article

Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice

scientific article published on 12 January 2017

Distinct behavioral and epileptic phenotype differences in 129/P mice compared to C57BL/6 mice subject to intraamygdala kainic acid-induced status epilepticus

scientific article published on 13 October 2016

Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice

scientific article published on 9 January 2017

Effects of transient focal cerebral ischemia in mice deficient in puma.

scientific article published on 13 January 2009

Elevated Plasma microRNA-206 Levels Predict Cognitive Decline and Progression to Dementia from Mild Cognitive Impairment

scientific article published on 13 November 2019

Elevated p53 and lower MDM2 expression in hippocampus from patients with intractable temporal lobe epilepsy

scientific article

Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus

scientific article

Expression and function of the metabotropic purinergic P2Y receptor family in experimental seizure models and patients with drug-refractory epilepsy

scientific article published on 21 July 2017

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

scientific article

Functional P2X<sub>7</sub> Receptors in the Auditory Nerve of Hearing Rodents Localize Exclusively to Peripheral Glia

scientific article published in 2021

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

scientific article

Haploinsufficient TNAP Mice Display Decreased Extracellular ATP Levels and Expression of Pannexin-1 Channels.

scientific article

High concordance between hippocampal transcriptome of the mouse intra-amygdala kainic acid model and human temporal lobe epilepsy

scientific article published on 18 October 2020

Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.

scientific article

In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury

scientific article published on 02 March 2011

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079.

scientific article published on 28 June 2013

Lithium, a potential protective drug in Alzheimer's disease

scientific article published on 06 March 2008

Looking for novel functions of tau.

scientific article published on August 2012

Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus

scientific article published on 7 October 2010

MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset

scientific article published on September 2016

MicroRNAs in Neurodegenerative Diseases.

scientific article published on 16 June 2017

Mitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain

scientific journal article

NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner

scientific article

Neonatal Seizures and Purinergic Signalling

scientific article published on 22 October 2020

Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation.

scientific article published on 27 July 2016

Overexpression of 14-3-3ζ Increases Brain Levels of C/EBP Homologous Protein CHOP.

scientific article published on 18 February 2015

P2X purinoceptors as a link between hyperexcitability and neuroinflammation in status epilepticus

scientific article published on 02 April 2015

P2X receptors as targets for the treatment of status epilepticus

scientific article

P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage

scientific article published on 21 April 2014

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.

scientific article

Purinergic signaling-induced neuroinflammation and status epilepticus

scientific article published on 30 March 2016

RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis.

scientific article

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma

scientific article published on 4 November 2009

Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis

scientific article

Regulation of P2X7 receptor expression and function in the brain

scientific article published on 26 December 2018

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice.

scientific article published on 23 December 2011

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

scientific article

Spatio-temporally restricted blood-brain barrier disruption after intra-amygdala kainic acid-induced status epilepticus in mice

scientific article published on 20 November 2012

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

scientific article published on 24 February 2017

Targeting the proteasome in epilepsy

scientific article published on 8 June 2017

Tau kinase I overexpression induces dentate gyrus degeneration

scientific article

Tau phosphorylation in hippocampus results in toxic gain-of-function.

scientific article published on August 2010

The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy

scientific article published on 2 February 2017

The Metabotropic Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy.

scientific article published on 7 March 2018

Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.

scientific article

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.

scientific article published in June 2016

Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice.

scientific article published on 4 April 2008

miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132

scientific article

microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

scientific article

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