List of works - Gavin I Welsh

A Composite Hydrogel Scaffold Permits Self-Organization and Matrix Deposition by Cocultured Human Glomerular Cells

scientific article published on 30 July 2019

A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli.

scientific article published on 9 February 2018

A role for NPY-NPY2R signaling in albuminuric kidney disease

scientific article published on 19 June 2020

A systems model of phosphorylation for inflammatory signaling events

scientific article

Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D2 dopamine receptors

scientific article published on 01 May 1998

Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase

scientific article published on 01 June 1997

Acute laminar shear stress reversibly increases human glomerular endothelial cell permeability via activation of endothelial nitric oxide synthase

scientific article

Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx

scientific article published on 31 October 2018

An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles

scientific article

Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease

scientific article published on 02 November 2019

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus

scientific article published on 10 November 2015

Clinical and genetic analysis of patients with cystinuria in the United Kingdom.

scientific article published on 11 May 2015

Clinical genetic testing using a custom-designed steroid-resistant nephrotic syndrome gene panel: analysis and recommendations

scientific article published on 05 August 2017

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease

scientific article

Depot-specific effects of fatty acids on lipid accumulation in children's adipocytes

scientific article published on 16 July 2007

Differential Expression of VEGF-Axxx Isoforms Is Critical for Development of Pulmonary Fibrosis

scientific article

Editorial: Podocyte Pathology and Nephropathy.

scientific article published on 17 September 2015

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF).

scientific article

Establishment of conditionally immortalized human glomerular mesangial cells in culture, with unique migratory properties.

scientific article published on 8 June 2011

Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts.

scientific article published on February 1993

Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid

scientific article published in April 2007

GSK3: a SHAGGY frog story

scientific article published on 01 July 1996

Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

scientific article published on 20 January 2017

Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans

scientific journal article

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes

scientific article

High fat feeding promotes obesity and renal inflammation and protects against post cardiopulmonary bypass acute kidney injury in swine

scientific article

High glucose causes dysfunction of the human glomerular endothelial glycocalyx ⬇️

scientific article published on October 27, 2010

Human Th17 cells produce a soluble mediator that increases podocyte motility via signaling pathways that mimic PAR-1 activation

scientific article published on 24 July 2019

IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

scientific article published on 24 March 2021

IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro

scientific article

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes

scientific article published on 15 September 2015

Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse.

scientific article

Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF-I, IGFBP-3 and TNFalpha

scientific article published on 4 August 2005

Kinetic regulation of multi-ligand binding proteins ⬇️

scientific article

Levamisole in steroid-sensitive nephrotic syndrome: usefulness in adult patients and laboratory insights into mechanisms of action via direct action on the kidney podocyte.

scientific article

Lighting up insulin action.

scientific article

MAGI2 Mutations Cause Congenital Nephrotic Syndrome

scientific article published on 8 December 2016

Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction.

scientific article published on 13 August 2014

Metabolite Changes in Maternal and Fetal Plasma Following Spontaneous Labour at Term in Humans Using Untargeted Metabolomics Analysis: A Pilot Study

scientific article published on 30 April 2019

Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells.

scientific article published on October 1995

Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes

scientific article published on 01 April 2007

Nerve and epidermal growth factor induce protein synthesis and eIF2B activation in PC12 cells

scientific article published on 01 March 1998

Nuclear translocation of IQGAP1 protein upon exposure to puromycin aminonucleoside in cultured human podocytes: ERK pathway involvement.

scientific article published in July 2016

Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.

scientific article published on January 1997

Phosphodiesterase-5 inhibition prevents postcardiopulmonary bypass acute kidney injury in swine

scientific article published on 08 October 2011

Phosphorylation of only serine-51 in protein synthesis initiation factor-2 is associated with inhibition of peptide-chain initiation in reticulocyte lysates

scientific article published on 01 May 1991

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

scientific article published in Nature Communications

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function

scientific article published on 01 July 2019

Podocyte RhoGTPases: new therapeutic targets for nephrotic syndrome?

scientific article published on 04 November 2019

Preeclamptic sera directly induce slit-diaphragm protein redistribution and alter podocyte barrier-forming capacity

scientific article published on 27 October 2008

Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade.

scientific article published in April 2011

Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.

scientific article published on 29 August 2017

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

scientific article published on 16 November 2004

Proteome analysis of adipogenesis.

scientific article published in April 2004

RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathways.

scientific article

Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx

scientific article

Regulation of Neph3 gene in podocytes--key roles of transcription factors NF-kappaB and Sp1.

scientific article published on 24 August 2009

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

scientific article

Regulation of initiation factor eIF-2B by GSK-3 regulated phosphorylation.

scientific article published on May 1997

Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms

scientific article published on 01 March 1997

Regulation of protein synthesis by insulin through IRS-1.

scientific article

Regulation of small GTP-binding proteins by insulin.

scientific article

Reversal of anemia with allogenic RBC transfusion prevents post-cardiopulmonary bypass acute kidney injury in swine.

scientific article

Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes.

scientific article published on 14 November 2007

Role of protein kinase B in insulin-regulated glucose uptake.

scientific article

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.

scientific article

Simultaneous sequencing of 24 genes associated with steroid-resistant nephrotic syndrome

scientific article published on 24 January 2013

Site-specific differences of insulin action in adipose tissue derived from normal prepubertal children

scientific article published on August 2005

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

scholarly article by Zhaoying Li published in September 2018

Studies with wortmannin indicate that insulin stimulation of lipogenesis involves multiple signalling pathways

scientific article published on 01 May 1995

T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3

scientific article

TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways

scientific article published on 17 January 2019

TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility

scientific article published on 15 August 2019

The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells.

scientific article published on 14 October 2017

The human glomerular podocyte is a novel target for insulin action

scientific article published on November 2005

Using green fluorescent protein to study intracellular signalling.

scientific article

VEGF and sVEGFR-1 in malignant pleural effusions: association with survival and pleurodesis outcomes

scientific article published on 07 April 2012

VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells.

scientific article published on 2 June 2017

VEGF regulates local inhibitory complement proteins in the eye and kidney.

scientific article published on 05 December 2016

VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy

scientific article published on 02 November 2018

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

scientific article published on October 1994

List of works by Gavin I Welsh

A Composite Hydrogel Scaffold Permits Self-Organization and Matrix Deposition by Cocultured Human Glomerular Cells

A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli.

A role for NPY-NPY2R signaling in albuminuric kidney disease

A systems model of phosphorylation for inflammatory signaling events

Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D2 dopamine receptors

Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase

Acute laminar shear stress reversibly increases human glomerular endothelial cell permeability via activation of endothelial nitric oxide synthase

Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx

An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles

Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus

Clinical and genetic analysis of patients with cystinuria in the United Kingdom.

Clinical genetic testing using a custom-designed steroid-resistant nephrotic syndrome gene panel: analysis and recommendations

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease

Depot-specific effects of fatty acids on lipid accumulation in children's adipocytes

Differential Expression of VEGF-Axxx Isoforms Is Critical for Development of Pulmonary Fibrosis

Editorial: Podocyte Pathology and Nephropathy.

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF).

Establishment of conditionally immortalized human glomerular mesangial cells in culture, with unique migratory properties.

Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts.

Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid

GSK3: a SHAGGY frog story

Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes

High fat feeding promotes obesity and renal inflammation and protects against post cardiopulmonary bypass acute kidney injury in swine

High glucose causes dysfunction of the human glomerular endothelial glycocalyx ⬇️

Human Th17 cells produce a soluble mediator that increases podocyte motility via signaling pathways that mimic PAR-1 activation

IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes

Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse.

Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF-I, IGFBP-3 and TNFalpha

Kinetic regulation of multi-ligand binding proteins ⬇️

Levamisole in steroid-sensitive nephrotic syndrome: usefulness in adult patients and laboratory insights into mechanisms of action via direct action on the kidney podocyte.

Lighting up insulin action.

MAGI2 Mutations Cause Congenital Nephrotic Syndrome

Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction.

Metabolite Changes in Maternal and Fetal Plasma Following Spontaneous Labour at Term in Humans Using Untargeted Metabolomics Analysis: A Pilot Study

Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells.

Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes

Nerve and epidermal growth factor induce protein synthesis and eIF2B activation in PC12 cells

Nuclear translocation of IQGAP1 protein upon exposure to puromycin aminonucleoside in cultured human podocytes: ERK pathway involvement.

Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.

Phosphodiesterase-5 inhibition prevents postcardiopulmonary bypass acute kidney injury in swine

Phosphorylation of only serine-51 in protein synthesis initiation factor-2 is associated with inhibition of peptide-chain initiation in reticulocyte lysates

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function

Podocyte RhoGTPases: new therapeutic targets for nephrotic syndrome?

Preeclamptic sera directly induce slit-diaphragm protein redistribution and alter podocyte barrier-forming capacity

Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade.

Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

Proteome analysis of adipogenesis.

RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathways.

Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx

Regulation of Neph3 gene in podocytes--key roles of transcription factors NF-kappaB and Sp1.

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

Regulation of initiation factor eIF-2B by GSK-3 regulated phosphorylation.

Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms

Regulation of protein synthesis by insulin through IRS-1.

Regulation of small GTP-binding proteins by insulin.

Reversal of anemia with allogenic RBC transfusion prevents post-cardiopulmonary bypass acute kidney injury in swine.

Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes.

Role of protein kinase B in insulin-regulated glucose uptake.

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.

Simultaneous sequencing of 24 genes associated with steroid-resistant nephrotic syndrome

Site-specific differences of insulin action in adipose tissue derived from normal prepubertal children

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

Studies with wortmannin indicate that insulin stimulation of lipogenesis involves multiple signalling pathways

T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3

TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways

TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility

The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells.

The human glomerular podocyte is a novel target for insulin action

Using green fluorescent protein to study intracellular signalling.

VEGF and sVEGFR-1 in malignant pleural effusions: association with survival and pleurodesis outcomes

VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells.

VEGF regulates local inhibitory complement proteins in the eye and kidney.