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List of works by Annabelle Lewis

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

scientific article (publication date: 2013)

A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA

scientific journal article

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding

scientific article published on 14 August 2014

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

scientific article published on December 2014

Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer.

scientific article published on 15 March 2017

Chromosome loops, insulators, and histone methylation: new insights into regulation of imprinting in clusters.

scientific article

Co-evolution of X-chromosome inactivation and imprinting in mammals

scientific article

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo

scientific article published on 4 October 2006

Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions

scientific article published in February 2003

Epigenetics and imprinting of the trophoblast -- a workshop report.

scientific article published on 3 April 2006

Erratum to “Epigenetics and Imprinting of the Trophoblast – A Workshop Report” [Placenta 27, supplement A, Trophoblast Research, Vol. 20 S122–S126]

scholarly article published in Placenta

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

scientific article

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

scientific journal article

Five endometrial cancer risk loci identified through genome-wide association analysis

scientific article published on 02 May 2016

Genomic imprinting: CTCF protects the boundaries

scientific article published on April 2004

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.

scientific article published on 6 May 2012

How imprinting centres work

scientific article

Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.

scientific article published on 31 October 2004

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

scientific article (publication date: May 2014)

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

scientific article

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

scientific article published on 8 December 2017

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

scientific article published on 6 October 2010

Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region

scientific article

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression

scientific article published on 25 February 2009

The C-terminus of Apc does not influence intestinal adenoma development or progression

scientific article

The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability

scientific article published on 08 July 2020

The Utility of Mouse Models in Post-GWAS Research ⬇️

scientific article published on December 7, 2012

The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing

scientific article published on 14 January 2009

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