List of works - Alessandro Natoni

A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization.

scientific article published on January 2013

A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response

scientific article (publication date: 2014)

Calicivirus translation initiation requires an interaction between VPg and eIF 4 E.

scientific article

Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

scientific article published on 24 July 2013

CyBorD-DARA is potent initial induction for MM and enhances ADCP: initial results of the 16-BCNI-001/CTRIAL-IE 16-02 study

scientific article published on 01 June 2019

E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271.

scientific article published on 25 April 2017

Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells.

scientific article

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

scientific article

Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells.

scientific article published on 27 April 2007

Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.

scientific article

Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.

scientific article published on 18 July 2011

NOXA contributes to the sensitivity of PERK-deficient cells to ER stress.

scientific article

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.

scientific article

Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model

scientific article published on 31 January 2020

TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2.

scientific article

Targeting AML through DR4 with a novel variant of rhTRAIL

scientific article

Targeting Selectins and Their Ligands in Cancer

scientific article

Targeting the Pim kinases in multiple myeloma

scientific article (publication date: 2015)

The mitochondrial pathway of apoptosis is triggered during feline calicivirus infection

scientific article published on February 2006

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma

scientific article

List of works by Alessandro Natoni

A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization.

A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response

Calicivirus translation initiation requires an interaction between VPg and eIF 4 E.

Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

CyBorD-DARA is potent initial induction for MM and enhances ADCP: initial results of the 16-BCNI-001/CTRIAL-IE 16-02 study

E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271.

Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells.

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells.

Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.

Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.

NOXA contributes to the sensitivity of PERK-deficient cells to ER stress.

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.

Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model

TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2.

Targeting AML through DR4 with a novel variant of rhTRAIL

Targeting Selectins and Their Ligands in Cancer

Targeting the Pim kinases in multiple myeloma

The mitochondrial pathway of apoptosis is triggered during feline calicivirus infection

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma