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List of works by Jens Lykkesfeldt

2-nitro-3-(p-hydroxyphenyl)propionate and aci-1-nitro-2-(p-hydroxyphenyl)ethane, two intermediates in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. ⬇️

scientific article published on January 1991

A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate®) ⬇️

scientific article published on April 16, 2012

Acetyl- l -carnitine fed to old rats partially restores mitochondrial function and ambulatory activity ⬇️

scientific article published on August 4, 1998

Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation.

scientific article published in September 1998

Age-dependent change in Vitamin C status: a phenomenon of maturation rather than of ageing

scientific article published on 25 April 2005

Ampicillin-improved glucose tolerance in diet-induced obese C57BL/6NTac mice is age dependent.

scientific article

Antioxidant supplementation does not alter endurance training adaptation

scientific article published in July 2010

Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle

scientific article published on 12 March 2007

Antioxidant supplementation for lung disease in cystic fibrosis

scientific article

Artemisinin induces omeprazole metabolism in human beings

scientific article published on 01 August 1998

Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used

scientific article

Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes.

scientific article published on February 2000

Ascorbate status modulates reticuloendothelial iron stores and response to deferasirox iron chelation in ascorbate-deficient rats.

scientific article

Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo

scientific article

Assessment of implantable infusion pumps for continuous infusion of human insulin in rats: potential for group housing

scientific article published on 27 July 2016

Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics: a case-control study

scientific article

Atorvastatin and Vitamin E Accelerates NASH Resolution by Dietary Intervention in a Preclinical Guinea Pig Model

scientific article published on 19 November 2019

Authors' perspective: What is the optimum intake of vitamin C in humans?

scientific article published on January 2012

Biopterin status in dogs with myxomatous mitral valve disease is associated with disease severity and cardiovascular risk factors.

scientific article published on September 2014

Brief Communication: Plasma lipid oxidation predicts atherosclerotic status better than cholesterol in diabetic apolipoprotein E deficient mice

scientific article published on 24 July 2016

Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice.

scientific article

Chronic Hyperinsulinaemic Hypoglycaemia in Rats Is Accompanied by Increased Body Weight, Hyperleptinaemia, and Decreased Neuronal Glucose Transporter Levels in the Brain

scientific article published on 21 March 2017

Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs.

scientific article published on 20 January 2012

Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression.

scientific article

Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin

scientific article published on 03 September 2013

Clarithromycin, trimethoprim, and penicillin and oxidative nucleic acid modifications in humans: randomised, controlled trials

scientific article

Comparison of Three Sample Preparation Procedures for the Quantification of L-Arginine, Asymmetric Dimethylarginine, and Symmetric Dimethylarginine in Human Plasma Using HPLC-FLD.

scientific article published in February 2018

Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults

scientific article

Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet-induced obesity

scientific article published on 18 March 2019

Determination of Ascorbic Acid and Dehydroascorbic Acid in Plasma by High-Performance Liquid Chromatography with Coulometric Detection - Are They Reliable Biomarkers of Oxidative Stress?

scientific article published on 01 August 1995

Determination of Reduced and Oxidized Coenzyme Q10 in Canine Plasma and Heart Tissue by HPLC-ECD: Comparison with LC-MS/MS Quantification

scientific article published on 30 July 2019

Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride

scientific article published on 01 June 2000

Determination of the disappearance rate of iodine-125 labelled oils from the injection site after intramuscular and subcutaneous administration to pigs.

scientific article published in November 2001

Diet-induced dyslipidemia leads to nonalcoholic fatty liver disease and oxidative stress in guinea pigs.

scientific article published on 22 October 2015

Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation

scientific article published on 01 September 2020

Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats

scientific article published on 24 January 2018

Differential toxicological response to positively and negatively charged nanoparticles in the rat brain.

scientific article published in November 2014

Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives

scientific article published on 30 March 2020

Distribution of enrofloxacin in intestinal tissue and contents of healthy pigs after oral and intramuscular administrations.

scientific article published in October 2002

Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs.

scientific article published on 13 April 2015

Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies.

scientific article published on 18 September 2015

Does Vitamin C Deficiency Increase Lifestyle-Associated Vascular Disease Progression? Evidence Based on Experimental and Clinical Studies ⬇️

scientific article published on June 20, 2013

Does vitamin C deficiency affect cognitive development and function?

scientific article

Does vitamin C deficiency promote fatty liver disease development?

scientific article

Does vitamin C deficiency result in impaired brain development in infants?

scientific article published in January 2009

Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies

scientific article published on 09 December 2013

Dyslipidemia: Obese or Not Obese-That Is Not the Question.

scientific article

Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model.

scientific article

Effect of High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers: A Randomized Controlled Crossover Pilot Study.

scientific article

Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training

article

Effect of insulin-induced hypoglycaemia on the central nervous system: evidence from experimental studies.

scientific article published on March 2014

Effect of insulin-induced hypoglycaemia on the peripheral nervous system: focus on adaptive mechanisms, pathogenesis and histopathological changes.

scientific article

Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat.

scientific article published on 3 February 2018

Effect of melatonin on human nighttime endotoxaemia: randomized, double-blinded, cross-over study.

scientific article published on November 2014

Effect of smoking cessation on plasma ascorbic acid concentration.

scientific article published on July 1996

Effect of smoking on erythorbic acid pharmacokinetics

scientific article published in May 2003

Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells

scientific article published on 21 March 2011

Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia.

scientific article

Elimination of ascorbic acid after high-dose infusion in prostate cancer patients: a pharmacokinetic evaluation

scientific article published on 7 October 2014

Endothelial dysfunction in the early postoperative period after major colon cancer surgery

scientific article

Erratum to: Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs.

scientific article published in June 2015

Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigs.

scientific article published in June 2003

Expression of endothelin type B receptors in uterine artery smooth muscle cells from pregnant Guinea pigs

scientific article published on 22 January 2019

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

scientific article published on 04 July 2018

Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposure.

scientific article published in October 2011

Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs

scientific article published on 5 March 2014

Glycemic Control during Pregnancy-A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women?

scientific article published on 31 May 2019

Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo

scientific article published on 13 August 2013

Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals

scientific article

Heterozygous Mutations in Gtp-Cyclohydrolase-1 Reduce Bh4 Biosynthesis but Not Pain Sensitivity.

scientific article published on 20 February 2018

High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs

scientific article published on 28 September 2010

High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs

scientific article published on 09 August 2016

High-fat feeding increases hepatic vitamin C synthesis and its circulatory mobilization in mice

scientific article

Histopathological nerve and skeletal muscle changes in rats subjected to persistent insulin-induced hypoglycemia

scientific article published on 29 October 2015

Importance of gestational hypoglycaemia for foetal malformations and skeletal development in rats

scientific article published on 20 October 2019

In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines.

scientific article published on 3 August 2016

In vivo toxicity of cationic micelles and liposomes

article

In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain.

scientific article published on 10 July 2014

Increased oxidative damage in vitamin C deficiency is accompanied by induction of ascorbic acid recycling capacity in young but not mature guinea pigs

scientific article published in May 2002

Increased systemic oxidatively generated DNA and RNA damage in schizophrenia

scientific article published on 01 March 2013

Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes

scientific article published on 02 August 2020

Involvement of cytochrome P450 in oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomal enzyme system isolated from jasmonic acid-induced seedlings of Sinapis alba L

scientific article

Is Diabetes Associated with Lower Vitamin C Status in Pregnant Women? A Prospective Study

scientific article published on 01 June 2016

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials

scientific article published on 15 December 2009

Keeping the intracellular vitamin C at a physiologically relevant level in endothelial cell culture.

scientific article published on 25 September 2009

Kinetics of acid-induced degradation of tetra- and dihydrobiopterin in relation to their relevance as biomarkers of endothelial function.

scientific article published on 15 October 2012

L-dehydroascorbic acid can substitute l-ascorbic acid as dietary vitamin C source in guinea pigs

scientific article

Long term Westernized diet leads to region-specific changes in brain signaling mechanisms

scientific article published on 12 April 2018

Lower limb ischaemia and reperfusion injury in healthy volunteers measured by oxidative and inflammatory biomarkers

scientific article published on 10 April 2014

Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking.

scientific article published on 7 February 2007

Markers of Oxidative Stress in Dogs with Myxomatous Mitral Valve Disease are Influenced by Sex, Neuter Status, and Serum Cholesterol Concentration.

scientific article published on 29 January 2017

Maternal vitamin C deficiency does not reduce hippocampal volume and β-tubulin III intensity in prenatal Guinea pigs

scientific article published on 6 March 2016

Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs

scientific article

Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs

scientific article published on 4 December 2014

Measurement of Ascorbic Acid and Dehydroascorbic Acid in Biological Samples ⬇️

scientific article published on August 1, 2002

Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction

Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model.

scientific article published on 17 October 2013

Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice

scientific article (publication date: 2016)

Morphine reduces spinal c-fos expression dose-dependently during experimental laparotomy in pigs: a combined pharmacokinetic and surgical study

scientific article published on 01 August 2007

Nephrectomized and hepatectomized animal models as tools in preclinical pharmacokinetics

scientific article

No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial.

scientific article published on October 2010

Non-terminal blood sampling techniques in guinea pigs

scientific article published on 11 October 2014

Normal weight dyslipidemia: Is it all about the liver?

scientific article published on 12 February 2016

Oxidants and antioxidants in disease: oxidative stress in farm animals.

scientific article published on 17 August 2006

Oxidative DNA damagein vivo: Relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion

scientific article published on 01 December 1998

Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance.

scientific article

Oxidative stress and damage in liver, but not in brain, of Fischer 344 rats subjected to dietary iron supplementation with lipid-soluble [(3,5,5-trimethylhexanoyl)ferrocene].

scientific article

Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation.

scientific article published in May 2005

Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial

scientific article published on 01 June 2012

Pasteurization Procedures for Donor Human Milk Affect Body Growth, Intestinal Structure, and Resistance against Bacterial Infections in Preterm Pigs

scientific article published on 15 March 2017

Pharmacokinetics of Repeated Oral Dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease

scientific article published on 04 September 2020

Pharmacokinetics of amoxicillin after oral administration in recently weaned piglets with experimentally induced Escherichia coli subtype O149:F4 diarrhea.

scientific article

Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles

scientific article

Poor Vitamin C Status Late in Pregnancy Is Associated with Increased Risk of Complications in Type 1 Diabetic Women: A Cross-Sectional Study

scientific article published on 23 February 2017

Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in guinea pigs.

scientific article published on 15 November 2011

Poor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with type 1 diabetes

scientific article published on 24 June 2009

Positive charge, negative effect: the impact of cationic nanoparticles in the brain.

scientific article

Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains

scientific article published on 20 January 2014

Prolonged effect of a new O-glycoPEGylated FVIII (N8-GP) in a murine saphenous vein bleeding model.

scientific article

Prolonged maternal vitamin C deficiency overrides preferential fetal ascorbate transport but does not influence perinatal survival in guinea pigs

scientific article published on 16 April 2013

Pronounced inflammatory response to endotoxaemia during nighttime: a randomised cross-over trial.

scientific article published on 27 January 2014

Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hindlimbs of Chronic Hypoglycaemic Rats

scientific article published on 06 September 2017

Pulsatile Hyperglycaemia Induces Vascular Oxidative Stress and GLUT 1 Expression More Potently than Sustained Hyperglycaemia in Rats on High Fat Diet

scientific article published on 20 January 2016

Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection.

scientific article published in June 2003

Regulation of vitamin C homeostasis during deficiency

scientific article

Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research

scientific article published on 15 August 2016

Role of marginal vitamin C deficiency in atherogenesis: in vivo models and clinical studies

scientific article

Role of vitamin C and E supplementation on IL-6 in response to training

scientific article published on 29 December 2011

Simultaneous determination of urinary free cortisol and 6β-hydroxycortisol by high-performance liquid chromatography to measure human CYP3A activity

scientific article published on 01 October 1994

Simultaneous quantification of monoamine neurotransmitters and their biogenic metabolites intracellularly and extracellularly in primary neuronal cell cultures and in sub-regions of guinea pig brain

scientific article published on 16 June 2016

Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial

scientific article published on 30 May 2016

Spatial Memory Dysfunction Induced by Vitamin C Deficiency Is Associated with Changes in Monoaminergic Neurotransmitters and Aberrant Synapse Formation

scientific article published on 29 June 2018

Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

scientific article published on 8 March 2011

Strategies for Using Plagiarism Software in the Screening of Incoming Journal Manuscripts: Recommendations Based on a Recent Literature Survey

scientific article

Synthesis of Benzylglucosinolate in Tropaeolum majus L. (Isothiocyanates as Potent Enzyme Inhibitors)

scientific article published on 01 June 1993

The Pharmacokinetics of Vitamin C

scientific article published on 09 October 2019

The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection -- a pilot study

scientific article published on 23 October 2014

The kidneys play a central role in the clearance of rhGH in rats.

scientific article published on 2 March 2016

The kidneys play an important role in the clearance of rFVIIa in rats

scientific article published on 25 March 2014

Thick methacrylate sections devoid of lost caps simplify stereological quantifications based on the optical fractionator design

scientific article published on 15 September 2015

Toxicological Effects during and following Persistent Insulin-Induced Hypoglycaemia in Healthy Euglycaemic Rats.

scientific article published on 20 February 2017

Translational aspects of rectal evoked potentials: a comparative study in rats and humans

scientific article published on 23 May 2013

Utility of melatonin to treat surgical stress after major vascular surgery--a safety study

scientific article

Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

scientific article published on 07 July 2018

Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

scientific article published on 26 February 2018

Vitamin C

scientific article published on 01 January 2014

Vitamin C Deficiency Reduces Muscarinic Receptor Coronary Artery Vasoconstriction and Plasma Tetrahydrobiopterin Concentration in Guinea Pigs

scientific article published on 3 July 2017

Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain

scientific article

Vitamin C pharmacokinetics of plain and slow release formulations in smokers

scientific article published in October 2004

Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers

scientific article

Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: a single-arm phase II trial

scientific article

Whey protein reduces early life weight gain in mice fed a high-fat diet

scientific article

[Nitrosamine formation via non-prescription drugs?]

scientific article published on 01 December 1993

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