List of works - Emilia Mellado

A Cyp51B Mutation Contributes to Azole Resistance in Aspergillus fumigatus

scientific article published on 26 November 2020

A New Aspergillus fumigatus Typing Method Based on Hypervariable Tandem Repeats Located within Exons of Surface Protein Coding Genes (TRESP).

scientific article

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

scientific article published on 19 March 2007

A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin

scientific article

A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus.

scientific article

Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds.

scientific article published on 17 February 2009

An alternative host model of a mixed fungal infection by azole susceptible and resistant Aspergillus spp strains

scientific article published on May 2015

An invertebrate model to evaluate virulence in Aspergillus fumigatus: the role of azole resistance.

scientific article published on 4 February 2014

Antifungal susceptibility profile of clinical Alternaria spp. identified by molecular methods

article

Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods.

scientific article published on 8 February 2008

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?

scientific article published in 2021

Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.

scientific article

Aspergillus fumigatus cyp51A polymorphisms, an insight on their significance.

scientific article published on 9 April 2018

Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.

scientific article

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

scientific article published on 01 December 2009

Blood and tissue distribution of posaconazole in a rat model of invasive pulmonary aspergillosis

scientific article

COVID-19 Associated Pulmonary Aspergillosis (CAPA): Hospital or Home Environment as a Source of Life-Threatening Aspergillus fumigatus Infection?

scientific article published in 2022

Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis virulence in the non-conventional host Galleria mellonella

scientific article

Candida tropicalis antifungal cross-resistance is related to different azole target (Erg11p) modifications.

scientific article published on 22 July 2013

Characterization of Aspergillus fumigatus cross-resistance between clinical and DMI azole drugs

scientific article published on 18 December 2020

Clinical relevance of resistance to antifungals.

scientific article

Comparison of Two Highly Discriminatory Typing Methods to Analyze Azole Resistance

scientific article published on 20 July 2018

Corrigendum to "First detection of Aspergillus fumigatus azole resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain" [New Microbes New Infect 6 (2015) 33-34].

scientific article published on 6 May 2016

Could the determination of Aspergillus fumigatus mating type have prognostic value in invasive aspergillosis?

scientific article published on 30 October 2017

Current status of antifungal resistance and its impact on clinical practice.

scientific article published on 18 April 2014

Deciphering the role of the chitin synthase families 1 and 2 in the in vivo and in vitro growth of Aspergillus fumigatus by multiple gene targeting deletion

scientific article

Development and validation of a High Resolution Melting Assay to detect azole resistance in Aspergillus fumigatus

scientific article published on 11 September 2017

Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

scientific article

Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain

scientific article published on 30 August 2010

Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.

scientific article published on 12 May 2008

Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance.

scientific article published on January 2012

Ergosterol biosynthesis pathway in Aspergillus fumigatus.

scientific article

First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain

scientific article published on 20 April 2015

Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus.

scientific article

Frequency of voriconazole resistance in vitro among Spanish clinical isolates of Candida spp. According to breakpoints established by the Antifungal Subcommittee of the European Committee on Antimicrobial Susceptibility Testing.

scientific article

Functional analysis of the fungal/plant class chitinase family in Aspergillus fumigatus

article

Galactomannan enzyme immunoassay and quantitative Real Time PCR as tools to evaluate the exposure and response in a rat model of aspergillosis after posaconazole prophylaxis

scientific article

Genetic relatedness versus biological compatibility between Aspergillus fumigatus and related species

scientific article

Genome-Wide Comparative Analysis of Aspergillus fumigatus Strains: The Reference Genome as a Matter of Concern

scientific article published on 19 July 2018

Genotype distribution of clinical isolates of Trichosporon asahii based on sequencing of intergenic spacer 1.

scientific article published on 16 May 2007

Halophilic bacteria as a source of novel hydrolytic enzymes

scientific article

Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi.

scientific article published on March 2006

Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010). ⬇️

scientific article published on 8 June 2015

Hospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations

scientific article published on 02 January 2021

In Vitro Activities of Three Licensed Antifungal Agents against Spanish Clinical Isolates of Aspergillus spp ⬇️

scientific article published on October 1, 2003

In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis.

scientific article published on June 2006

In vitro activity of antifungals against Zygomycetes.

scientific article published on October 2009

In vitro activity of ravuconazole against 923 clinical isolates of nondermatophyte filamentous fungi.

scientific article published on December 2005

In vivo efficacy of voriconazole and posaconazole therapy in a novel invertebrate model of Aspergillus fumigatus infection

scientific article published on 17 August 2015

Interlaboratory reproducibility of a microsatellite-based typing assay for Aspergillus fumigatus through the use of allelic ladders: proof of concept

scientific article published on 10 January 2009

Interlaboratory reproducibility of a single-locus sequence-based method for strain typing of Aspergillus fumigatus

scientific article published on 04 March 2009

Invasive aspergillosis caused by cryptic Aspergillus species: a report of two consecutive episodes in a patient with leukaemia.

scientific article

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for fast and accurate identification of clinically relevant Aspergillus species.

scientific article

Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability.

scientific article published on 14 April 2010

Molecular identification, antifungal resistance and virulence of Cryptococcus neoformans and Cryptococcus deneoformans isolated in Seville, Spain.

scientific article published on 15 September 2016

Multiple-Triazole–Resistant Aspergillosis

scientific article published on 01 April 2007

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

scientific article published on 25 March 2016

Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in Aspergillus flavus

scientific article published on 17 October 2020

Polyphasic characterization of fungal isolates from a published case of invasive aspergillosis reveals misidentification of Aspergillus felis as Aspergillus viridinutans

scientific article published on 27 January 2014

Population-Based Survey of Filamentous Fungi and Antifungal Resistance in Spain (FILPOP Study).

scientific article published on September 2013

Population-based survey of filamentous fungi and antifungal resistance in Spain (FILPOP Study).

scientific article published on 13 May 2013

Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides

scientific article (publication date: August 2016)

Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

scientific article published on June 2015

Pulmonary mycetoma caused by an atypical isolate of Paecilomyces species in an immunocompetent individual: case report and literature review of Paecilomyces lung infections.

scientific article

Rapid development of Candida krusei echinocandin resistance during caspofungin therapy

scientific article

Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis

scientific article

Ribosomic DNA intergenic spacer 1 region is useful when identifying Candida parapsilosis spp. complex based on high-resolution melting analysis.

scientific article published on 20 May 2014

Role of Aspergillus lentulus 14-α sterol demethylase (Cyp51A) in azole drug susceptibility.

scientific article published on 26 September 2011

Species identification and antifungal susceptibility patterns of species belonging to Aspergillus section Nigri.

scientific article published on 27 July 2009

Susceptibility testing and molecular classification of Paecilomyces spp.

scientific article published on 2 June 2008

The ZrfC alkaline zinc transporter is required for Aspergillus fumigatus virulence and its growth in the presence of the Zn/Mn-chelating protein calprotectin.

scientific article published on 4 December 2013

Triazole Resistance in Aspergillus Species: An Emerging Problem

scientific article

Triazole Resistance in Aspergillus spp.: A Worldwide Problem?

scientific article

[Detection of Aspergillus spp. by real-time PCR in a murine model of pulmonary infection].

scientific article

List of works by Emilia Mellado

A Cyp51B Mutation Contributes to Azole Resistance in <i>Aspergillus fumigatus</i>

A New Aspergillus fumigatus Typing Method Based on Hypervariable Tandem Repeats Located within Exons of Surface Protein Coding Genes (TRESP).

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin

A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus.

Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds.

An alternative host model of a mixed fungal infection by azole susceptible and resistant Aspergillus spp strains

An invertebrate model to evaluate virulence in Aspergillus fumigatus: the role of azole resistance.

Antifungal susceptibility profile of clinical Alternaria spp. identified by molecular methods

Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods.

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?

Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.

Aspergillus fumigatus cyp51A polymorphisms, an insight on their significance.

Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

Blood and tissue distribution of posaconazole in a rat model of invasive pulmonary aspergillosis

COVID-19 Associated Pulmonary Aspergillosis (CAPA): Hospital or Home Environment as a Source of Life-Threatening Aspergillus fumigatus Infection?

Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis virulence in the non-conventional host Galleria mellonella

Candida tropicalis antifungal cross-resistance is related to different azole target (Erg11p) modifications.

Characterization of <i>Aspergillus fumigatus</i> cross-resistance between clinical and DMI azole drugs

Clinical relevance of resistance to antifungals.

Comparison of Two Highly Discriminatory Typing Methods to Analyze Azole Resistance

Corrigendum to "First detection of Aspergillus fumigatus azole resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain" [New Microbes New Infect 6 (2015) 33-34].

Could the determination of Aspergillus fumigatus mating type have prognostic value in invasive aspergillosis?

Current status of antifungal resistance and its impact on clinical practice.

Deciphering the role of the chitin synthase families 1 and 2 in the in vivo and in vitro growth of Aspergillus fumigatus by multiple gene targeting deletion

Development and validation of a High Resolution Melting Assay to detect azole resistance in Aspergillus fumigatus

Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain

Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.

Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance.

Ergosterol biosynthesis pathway in Aspergillus fumigatus.

First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain

Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus.

Frequency of voriconazole resistance in vitro among Spanish clinical isolates of Candida spp. According to breakpoints established by the Antifungal Subcommittee of the European Committee on Antimicrobial Susceptibility Testing.

Functional analysis of the fungal/plant class chitinase family in Aspergillus fumigatus

Galactomannan enzyme immunoassay and quantitative Real Time PCR as tools to evaluate the exposure and response in a rat model of aspergillosis after posaconazole prophylaxis

Genetic relatedness versus biological compatibility between Aspergillus fumigatus and related species

Genome-Wide Comparative Analysis of Aspergillus fumigatus Strains: The Reference Genome as a Matter of Concern

Genotype distribution of clinical isolates of Trichosporon asahii based on sequencing of intergenic spacer 1.

Halophilic bacteria as a source of novel hydrolytic enzymes

Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi.

Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010). ⬇️

Hospital Environment as a Source of Azole-Resistant <i>Aspergillus fumigatus</i> Strains with TR34/L98H and G448S Cyp51A Mutations

In Vitro Activities of Three Licensed Antifungal Agents against Spanish Clinical Isolates of Aspergillus spp ⬇️

In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis.

In vitro activity of antifungals against Zygomycetes.

In vitro activity of ravuconazole against 923 clinical isolates of nondermatophyte filamentous fungi.

In vivo efficacy of voriconazole and posaconazole therapy in a novel invertebrate model of Aspergillus fumigatus infection

Interlaboratory reproducibility of a microsatellite-based typing assay for Aspergillus fumigatus through the use of allelic ladders: proof of concept

Interlaboratory reproducibility of a single-locus sequence-based method for strain typing of Aspergillus fumigatus

Invasive aspergillosis caused by cryptic Aspergillus species: a report of two consecutive episodes in a patient with leukaemia.

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for fast and accurate identification of clinically relevant Aspergillus species.

Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability.

Molecular identification, antifungal resistance and virulence of Cryptococcus neoformans and Cryptococcus deneoformans isolated in Seville, Spain.

Multiple-Triazole–Resistant Aspergillosis

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in Aspergillus flavus

Polyphasic characterization of fungal isolates from a published case of invasive aspergillosis reveals misidentification of Aspergillus felis as Aspergillus viridinutans

Population-Based Survey of Filamentous Fungi and Antifungal Resistance in Spain (FILPOP Study).

Population-based survey of filamentous fungi and antifungal resistance in Spain (FILPOP Study).

Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides

Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

Pulmonary mycetoma caused by an atypical isolate of Paecilomyces species in an immunocompetent individual: case report and literature review of Paecilomyces lung infections.

Rapid development of Candida krusei echinocandin resistance during caspofungin therapy

Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis

Ribosomic DNA intergenic spacer 1 region is useful when identifying Candida parapsilosis spp. complex based on high-resolution melting analysis.

Role of Aspergillus lentulus 14-α sterol demethylase (Cyp51A) in azole drug susceptibility.

Species identification and antifungal susceptibility patterns of species belonging to Aspergillus section Nigri.

Susceptibility testing and molecular classification of Paecilomyces spp.

The ZrfC alkaline zinc transporter is required for Aspergillus fumigatus virulence and its growth in the presence of the Zn/Mn-chelating protein calprotectin.

Triazole Resistance in Aspergillus Species: An Emerging Problem

Triazole Resistance in Aspergillus spp.: A Worldwide Problem?

[Detection of Aspergillus spp. by real-time PCR in a murine model of pulmonary infection].