List of works - Bradley J Turner

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

scientific article

AMPK Signalling and Defective Energy Metabolism in Amyotrophic Lateral Sclerosis

scientific article published on 23 July 2015

Alzheimer's disease therapeutics: new approaches to an ageing problem.

scientific article published in April 2004

Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting

scientific article published on 04 November 2020

Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

scientific article published on 23 May 2019

Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice

scientific article published on 01 November 2003

Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis

scientific article published in August 2003

Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1.

scientific article published in December 2004

Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair

scientific article

Chemotherapy delays progression of motor neuron disease in the SOD1 G93A transgenic mouse

scientific article published on 01 June 2004

Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts.

scientific article

Design and application of a peptide nucleic acid sequence targeting the p75 neurotrophin receptor

scientific article published on 01 July 2003

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

scientific article published on 27 October 2011

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

scientific article published on 23 February 2016

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

scientific article published on 15 December 2009

Diverse roles for Wnt7a in ventral midbrain neurogenesis and dopaminergic axon morphogenesis.

scientific article

Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

scientific article published on 26 September 2013

ER stress and UPR in familial amyotrophic lateral sclerosis.

scientific article

Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice.

scientific article

Emerging therapies and challenges in spinal muscular atrophy

scientific article

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

scientific article published on 27 July 2016

Exploring germline recombination in Nestin-Cre transgenic mice using floxed androgen receptor

scientific article published on 03 August 2020

Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells.

scientific article

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

scientific journal article

Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.

scientific article published in April 2004

Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment

scientific article published on 26 October 2015

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

scientific article published on 18 February 2014

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell

scientific article published on 14 January 2014

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis.

scientific article published on 13 November 2013

Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS

scientific article published on 14 May 2020

Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.

scientific article

Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS

scientific article published on 19 November 2019

Neuromuscular accumulation of mutant superoxide dismutase 1 aggregates in a transgenic mouse model of familial amyotrophic lateral sclerosis

scientific article published on 01 October 2003

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

scientific article

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.

scientific article published on 24 October 2013

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

scientific article

Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression

scientific article

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

scientific article

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice.

scientific article published on 25 January 2010

Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model.

scientific article published on 28 March 2009

Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.

scientific article published on 5 August 2016

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy

scientific article

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

scientific article

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

scientific article published on 12 January 2015

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

scientific article published on 13 March 2020

The beta-amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane.

scientific article published on 3 November 2005

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.

scientific article published on 21 October 2013

The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis.

scientific article published in September 2003

α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosis

scientific article published on 31 March 2022

List of works by Bradley J Turner

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

AMPK Signalling and Defective Energy Metabolism in Amyotrophic Lateral Sclerosis

Alzheimer's disease therapeutics: new approaches to an ageing problem.

Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting

Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice

Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis

Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1.

Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair

Chemotherapy delays progression of motor neuron disease in the SOD1 G93A transgenic mouse

Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts.

Design and application of a peptide nucleic acid sequence targeting the p75 neurotrophin receptor

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

Diverse roles for Wnt7a in ventral midbrain neurogenesis and dopaminergic axon morphogenesis.

Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

ER stress and UPR in familial amyotrophic lateral sclerosis.

Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice.

Emerging therapies and challenges in spinal muscular atrophy

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Exploring germline recombination in Nestin-Cre transgenic mice using floxed androgen receptor

Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells.

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.

Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis.

Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS

Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.

Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS

Neuromuscular accumulation of mutant superoxide dismutase 1 aggregates in a transgenic mouse model of familial amyotrophic lateral sclerosis

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice.

Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model.

Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

The beta-amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane.

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.

The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis.

α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosis