List of works - Pietro Luigi Poliani

A gene therapy approach to treat demyelinating diseases using nonreplicative herpetic vectors engineered to produce cytokines ⬇️

scientific article published on June 1, 1998

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.

scientific article

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development

scientific article published on 15 April 2011

Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID

scientific article

Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients

scientific article published on 11 January 2017

Anti-CD3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications

scientific article published on 21 June 2012

Brain engraftment and therapeutic potential of stem/progenitor cells derived from mouse skin.

scientific article published in April 2006

CCRL2 regulates M1/M2 polarization during EAE recovery phase

scientific article published on 07 January 2016

CEACAM1/VEGF cross-talk during neuroblastic tumour differentiation

scientific article published on 01 April 2007

Caveolin 1 is a marker of poor differentiation in Rhabdomyosarcoma

scientific article

Caveolin-1, Caveolin-2 and Cavin-1 are strong predictors of adipogenic differentiation in human tumors and cell lines of liposarcoma

scientific article published on 4 May 2016

Caveolins in rhabdomyosarcoma ⬇️

scientific article published on December 1, 2011

Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma

scientific article

Cavin-2 is a specific marker for detection of well-differentiated liposarcoma

scientific article

Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination

scientific article published on 01 November 1998

Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice.

scientific article published in January 2001

Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection.

scientific article published on 15 January 2011

Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors

scientific article published on 22 April 2020

Constitutional de novo deletion of the FBXW7 gene in a patient with focal segmental glomerulosclerosis and multiple primitive tumors

scientific article published on 20 October 2015

Correction of murine Rag2 severe combined immunodeficiency by lentiviral gene therapy using a codon-optimized RAG2 therapeutic transgene

scientific article

Critical role for prokineticin 2 in CNS autoimmunity

scientific article

Cutaneous distribution of plasmacytoid dendritic cells in lupus erythematosus. Selective tropism at the site of epithelial apoptotic damage

scientific article published on 21 July 2009

Cytokines and immunity in multiple sclerosis: the dual signal hypothesis.

scientific article

DNA threads released by activated CD4+ T lymphocytes provide autocrine costimulation

scientific article published on 15 April 2019

Defect of regulatory T cells in patients with Omenn syndrome

scientific article published on 01 January 2010

Development of an HSV-based vector for the treatment of Parkinson's disease

scientific article published on March 1997

Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein

scientific article published on 23 January 2014

Dexamethasone inhibits the anti-tumor effect of interleukin 4 on rat experimental gliomas.

scientific article published in January 2003

EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide

scientific article published on 3 March 2015

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay

scientific article

Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome

scientific article published on 04 May 2009

Efficacy of the EDP-M Scheme Plus Adjunctive Surgery in the Management of Patients with Advanced Adrenocortical Carcinoma: The Brescia Experience

scientific article published on 10 April 2020

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.

scientific article

Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis

scientific article

Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma

scientific article published in April 2007

Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice.

scientific article published on 14 February 2011

Exacerbation of experimental autoimmune encephalomyelitis by passive transfer of IgG antibodies from a multiple sclerosis patient responsive to immunoadsorption

scientific article

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency

scientific article

Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1.

scientific article published on 2 March 2006

Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice.

scientific article published on August 2001

Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification.

scientific article

Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme

scientific article

High doses of cobalt induce optic and auditory neuropathy

scientific article published on 12 October 2012

Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

scientific article

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome

scientific article

Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells

scientific article

Hypomorphic Rag mutations can cause destructive midline granulomatous disease

scientific article

Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration.

scientific article published on 19 September 2013

IL-10 critically modulates B cell responsiveness in Rankl-/- mice.

scientific article published on 30 March 2015

Immunophenotypic and genotypic analysis of a case of primary peripheral primitive neuroectodermal tumour (pPNET) of the urinary bladder

scientific article published on 01 January 2002

In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott-Aldrich Syndrome Protein-Deficient B Cells.

scientific article

Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3)

scientific article published on 01 February 2000

Inhibition of angiogenesis by β-galactosylceramidase deficiency in globoid cell leukodystrophy.

scientific article published on September 2013

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

scientific article

Intra-tumoral dendritic cells increase efficacy of peripheral vaccination by modulation of glioma microenvironment

scientific article published on 6 January 2010

Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome

scientific article

Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function.

scientific article published on 9 February 2017

MET inhibition overcomes radiation resistance of glioblastoma stem-like cells

scientific article published on 02 May 2016

MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line

scientific article published on 18 June 2015

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin

scientific article published on 7 June 2009

Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas

scientific article published in November 2006

Of Omenn and mice.

scientific article published on 05 February 2008

Osteopetrosis rescue upon RANKL administration to Rankl(-/-) mice: a new therapy for human RANKL-dependent ARO.

scientific article

Pattern of relapse of glioblastoma multiforme treated with radical radio-chemotherapy: Could a margin reduction be proposed?

scientific article published on 30 March 2016

Phosphocaveolin-1 enforces tumor growth and chemoresistance in rhabdomyosarcoma.

scientific article published on 10 January 2014

Post-surgical therapeutic approaches to glioblastoma patients submitted to biopsy (BA) or "partial" resection (PR): the possibilities to treat also them without renunciations. Study from the Brescia Neuro-Oncology Group

scientific article published on 15 March 2015

Rag defects and thymic stroma: lessons from animal models.

scientific article

Recombination-activating gene 1 (Rag1)-deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome

scientific article published on 9 December 2013

Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells

scientific article published in March 2005

Reply: To PMID 24332219.

scientific article published on 26 June 2014

Schwann cells in neuroblastoma express erythropoietin

scientific article published on 13 December 2006

Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case

scientific article published on 03 December 2008

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions

scientific article published in November 2011

Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains

scientific article published on 13 January 2018

TREM2 sustains microglial expansion during aging and response to demyelination

scientific article published on 20 April 2015

The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses

article

The therapeutic potential of neural stem/progenitor cells in murine globoid cell leukodystrophy is conditioned by macrophage/microglia activation

scientific article published on 30 September 2005

The treatment of patients with 1-3 brain metastases: is there a place for whole brain radiotherapy alone, yet? A retrospective analysis

scientific article published on 28 April 2015

Thymus microenvironment in human primary immunodeficiency diseases.

scientific article published on December 2009

Thymus transplantation for complete DiGeorge syndrome: European experience.

scientific article

Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models

scientific article

Treatment with anti-FcεRIα antibody exacerbates EAE and T-cell immunity against myelin.

scientific article

miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression

scientific article published in May 2015

ζ Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance

scientific article published on 14 December 2012

List of works by Pietro Luigi Poliani

A gene therapy approach to treat demyelinating diseases using nonreplicative herpetic vectors engineered to produce cytokines ⬇️

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development

Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID

Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients

Anti-CD3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications

Brain engraftment and therapeutic potential of stem/progenitor cells derived from mouse skin.

CCRL2 regulates M1/M2 polarization during EAE recovery phase

CEACAM1/VEGF cross-talk during neuroblastic tumour differentiation

Caveolin 1 is a marker of poor differentiation in Rhabdomyosarcoma

Caveolin-1, Caveolin-2 and Cavin-1 are strong predictors of adipogenic differentiation in human tumors and cell lines of liposarcoma

Caveolins in rhabdomyosarcoma ⬇️

Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma

Cavin-2 is a specific marker for detection of well-differentiated liposarcoma

Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination

Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice.

Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection.

Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors

Constitutional de novo deletion of the FBXW7 gene in a patient with focal segmental glomerulosclerosis and multiple primitive tumors

Correction of murine Rag2 severe combined immunodeficiency by lentiviral gene therapy using a codon-optimized RAG2 therapeutic transgene

Critical role for prokineticin 2 in CNS autoimmunity

Cutaneous distribution of plasmacytoid dendritic cells in lupus erythematosus. Selective tropism at the site of epithelial apoptotic damage

Cytokines and immunity in multiple sclerosis: the dual signal hypothesis.

DNA threads released by activated CD4+ T lymphocytes provide autocrine costimulation

Defect of regulatory T cells in patients with Omenn syndrome

Development of an HSV-based vector for the treatment of Parkinson's disease

Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein

Dexamethasone inhibits the anti-tumor effect of interleukin 4 on rat experimental gliomas.

EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay

Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome

Efficacy of the EDP-M Scheme Plus Adjunctive Surgery in the Management of Patients with Advanced Adrenocortical Carcinoma: The Brescia Experience

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.

Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis

Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma

Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice.

Exacerbation of experimental autoimmune encephalomyelitis by passive transfer of IgG antibodies from a multiple sclerosis patient responsive to immunoadsorption

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency

Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1.

Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice.

Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification.

Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme

High doses of cobalt induce optic and auditory neuropathy

Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome

Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells

Hypomorphic Rag mutations can cause destructive midline granulomatous disease

Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration.

IL-10 critically modulates B cell responsiveness in Rankl-/- mice.

Immunophenotypic and genotypic analysis of a case of primary peripheral primitive neuroectodermal tumour (pPNET) of the urinary bladder

In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott-Aldrich Syndrome Protein-Deficient B Cells.

Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3)

Inhibition of angiogenesis by β-galactosylceramidase deficiency in globoid cell leukodystrophy.

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Intra-tumoral dendritic cells increase efficacy of peripheral vaccination by modulation of glioma microenvironment

Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome

Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function.

MET inhibition overcomes radiation resistance of glioblastoma stem-like cells

MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin

Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas

Of Omenn and mice.

Osteopetrosis rescue upon RANKL administration to Rankl(-/-) mice: a new therapy for human RANKL-dependent ARO.

Pattern of relapse of glioblastoma multiforme treated with radical radio-chemotherapy: Could a margin reduction be proposed?

Phosphocaveolin-1 enforces tumor growth and chemoresistance in rhabdomyosarcoma.

Post-surgical therapeutic approaches to glioblastoma patients submitted to biopsy (BA) or "partial" resection (PR): the possibilities to treat also them without renunciations. Study from the Brescia Neuro-Oncology Group

Rag defects and thymic stroma: lessons from animal models.

Recombination-activating gene 1 (Rag1)-deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome

Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells

Reply: To PMID 24332219.

Schwann cells in neuroblastoma express erythropoietin

Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions

Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains

TREM2 sustains microglial expansion during aging and response to demyelination

The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses

The therapeutic potential of neural stem/progenitor cells in murine globoid cell leukodystrophy is conditioned by macrophage/microglia activation

The treatment of patients with 1-3 brain metastases: is there a place for whole brain radiotherapy alone, yet? A retrospective analysis

Thymus microenvironment in human primary immunodeficiency diseases.