List of works - John Curnow

A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease ⬇️

scientific article

A threshold level of TLR9 mRNA predicts cellular responsiveness to CpG-ODN in haematological and non-haematological tumour cell lines.

scientific article

Aqueous humor suppression of dendritic cell function helps maintain immune regulation in the eye during human uveitis

scientific article published on 21 February 2012

Association analysis of TGFBR3 gene with Behçet's disease and idiopathic intermediate uveitis in a Caucasian population.

scientific article published on 12 February 2015

Bridging innate and adaptive immunity: removing the toll

scientific article published on 29 July 2011

CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells.

scientific article published on 20 March 2017

CD8 requirements for negative selection events are directly related to the TCR-antigen interaction

scientific article published on 01 January 1994

CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation.

scientific article

Cerebrospinal fluid immunoglobulin light chain ratios predict disease progression in multiple sclerosis

scientific article published on 09 May 2018

Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye

scientific article published on 01 August 2006

Conjunctival Neutrophils Predict Progressive Scarring in Ocular Mucous Membrane Pemphigoid

scientific article published on October 2016

Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatment.

scientific article

Cytokine production and antigen recognition by human mucosal homing conjunctival effector memory CD8+ T cells

scientific article

Cytoplasmic calcium fluxes induced in cytotoxic effector cells by engagement of Fc gamma receptors I, II, and III

scientific article published on August 1, 1992

Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis

article

Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis.

scientific article published on January 2008

Differential survival of leucocyte subsets by synovial, bone marrow and skin fibroblasts: site-specific rescue of CD4 T cells versus activation-induced rescue of neutrophils

Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum

scientific article (publication date: 2010)

Diverse patterns of unresponsiveness in an acetylcholine receptor-specific T-cell clone from a myasthenia gravis patient after engaging the T-cell receptor with three different ligands

scientific article published on 01 March 1998

Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury.

scientific article published on 24 December 2009

EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15

scientific article

Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome

scientific article published on 01 November 2001

Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?

scientific article published on 2 September 2008

Elevation of conjunctival epithelial CD45INTCD11b⁺CD16⁺CD14⁻ neutrophils in ocular Stevens-Johnson syndrome and toxic epidermal necrolysis.

scientific article published on 10 July 2013

Endogenous Cortisol and TGF- in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function

scientific article published on 24 November 2010

Epstein-Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-kappaB transcription factor pathway.

scholarly article

Exploring the pathogenesis of IIH: an inflammatory perspective

scientific article published on 03 August 2008

High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

scientific article published on 08 August 2014

Induction of primary immune responses by allogeneic human myoblasts: dissection of the cell types required for proliferation, IFNgamma secretion and cytotoxicity

scientific article published in June 1998

Inflammatory mediators of uveitis: cytokines and chemokines.

scientific article published on December 2006

Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling.

scientific article published in October 2004

Intraocular Immune Mechanisms in Uveitis

Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo-reactivity

scientific article published on 05 December 2014

Memory T cells constitute a subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics.

scientific article

Multiplex Bead Analysis of Vitreous Humor of Patients with Vitreoretinal Disorders

scientific article published on 01 May 2007

Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis.

scientific article published in November 2005

Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors

scientific article published on 17 October 2015

Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium.

scientific article published on September 2000

Phenotypic and functional differentiation of KG-1 into dendritic-like cells.

scientific article published on August 2007

Presentation by myoblasts of an epitope from endogenous acetylcholine receptor indicates a potential role in the spreading of the immune response

scientific article

Restricted IgG1 subclass of anti-Yo antibodies in paraneoplastic cerebellar degeneration

scientific article published on 01 March 2001

Serum cytokine profiles in Behçet's disease: Is there a role for IL-15 in pathogenesis?

scientific article published on 13 August 2008

Soluble gp130, an antagonist of IL-6 transsignaling, is elevated in uveitis aqueous humor.

scientific article published on 9 May 2008

Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis

scientific article published on January 2006

TCR-associated zeta-Fc epsilon RI gamma heterodimers on CD4-CD8- NK1.1+ T cells selected by specific class I MHC antigen

scientific article published on 01 October 1995

The balance between deletion and activation of CD4+8+ thymocytes is controlled by T cell receptor-antigen interactions and is affected by cyclosporin A

scientific article published on 01 October 1994

The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis

scientific article published in October 2002

The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice

scholarly article by Nathalie Auphan et al published July 1994 in European Journal of Immunology

The generation and antigen-specificity of CD4+CD25+ regulatory T cells.

scientific article published on September 2006

The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue

scientific article published on 01 November 2011

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy

scientific article published on 30 October 2009

The role of apoptosis in antibody-dependent cellular cytotoxicity.

scientific article published in January 1993

Validation of a fornix depth measurer: a putative tool for the assessment of progressive cicatrising conjunctivitis

scientific article

Vernal keratoconjunctivitis-like disease in adults.

scientific article published on 23 January 2013

List of works by John Curnow

A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease ⬇️

A threshold level of TLR9 mRNA predicts cellular responsiveness to CpG-ODN in haematological and non-haematological tumour cell lines.

Aqueous humor suppression of dendritic cell function helps maintain immune regulation in the eye during human uveitis

Association analysis of TGFBR3 gene with Behçet's disease and idiopathic intermediate uveitis in a Caucasian population.

Bridging innate and adaptive immunity: removing the toll

CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells.

CD8 requirements for negative selection events are directly related to the TCR-antigen interaction

CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation.

Cerebrospinal fluid immunoglobulin light chain ratios predict disease progression in multiple sclerosis

Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye

Conjunctival Neutrophils Predict Progressive Scarring in Ocular Mucous Membrane Pemphigoid

Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatment.

Cytokine production and antigen recognition by human mucosal homing conjunctival effector memory CD8+ T cells

Cytoplasmic calcium fluxes induced in cytotoxic effector cells by engagement of Fc gamma receptors I, II, and III

Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis

Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis.

Differential survival of leucocyte subsets by synovial, bone marrow and skin fibroblasts: site-specific rescue of CD4 T cells versus activation-induced rescue of neutrophils

Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum

Diverse patterns of unresponsiveness in an acetylcholine receptor-specific T-cell clone from a myasthenia gravis patient after engaging the T-cell receptor with three different ligands

Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury.

EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15

Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome

Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?

Elevation of conjunctival epithelial CD45INTCD11b⁺CD16⁺CD14⁻ neutrophils in ocular Stevens-Johnson syndrome and toxic epidermal necrolysis.

Endogenous Cortisol and TGF- in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function

Epstein-Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-kappaB transcription factor pathway.

Exploring the pathogenesis of IIH: an inflammatory perspective

High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

Induction of primary immune responses by allogeneic human myoblasts: dissection of the cell types required for proliferation, IFNgamma secretion and cytotoxicity

Inflammatory mediators of uveitis: cytokines and chemokines.

Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling.

Intraocular Immune Mechanisms in Uveitis

Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo-reactivity

Memory T cells constitute a subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics.

Multiplex Bead Analysis of Vitreous Humor of Patients with Vitreoretinal Disorders

Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis.

Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors

Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium.

Phenotypic and functional differentiation of KG-1 into dendritic-like cells.

Presentation by myoblasts of an epitope from endogenous acetylcholine receptor indicates a potential role in the spreading of the immune response

Restricted IgG1 subclass of anti-Yo antibodies in paraneoplastic cerebellar degeneration

Serum cytokine profiles in Behçet's disease: Is there a role for IL-15 in pathogenesis?

Soluble gp130, an antagonist of IL-6 transsignaling, is elevated in uveitis aqueous humor.

Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis

TCR-associated zeta-Fc epsilon RI gamma heterodimers on CD4-CD8- NK1.1+ T cells selected by specific class I MHC antigen

The balance between deletion and activation of CD4+8+ thymocytes is controlled by T cell receptor-antigen interactions and is affected by cyclosporin A

The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis

The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice

The generation and antigen-specificity of CD4+CD25+ regulatory T cells.

The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy

The role of apoptosis in antibody-dependent cellular cytotoxicity.

Validation of a fornix depth measurer: a putative tool for the assessment of progressive cicatrising conjunctivitis

Vernal keratoconjunctivitis-like disease in adults.