List of works - Stephan Hahn

A genetic roadmap of pancreatic cancer: still evolving

scientific article published on 9 October 2017

A microRNA-based test improves endoscopic ultrasound-guided cytologic diagnosis of pancreatic cancer.

scientific article

A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding

scientific article published in 2014

A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.

scientific article published on 19 January 2015

A web-based platform for mining pancreatic expression datasets

scientific article published on 18 May 2009

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas ⬇️

scientific article published on 01 August 1997

Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis

scientific article

Analysis of U2 small nuclear RNA fragments in the bile differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders

scientific article published on 31 January 2014

Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation

scientific article published on 01 April 2009

Anticipation in familial pancreatic cancer.

scientific article published on 21 June 2005

Application of fluorescence difference gel electrophoresis saturation labelling for the analysis of microdissected precursor lesions of pancreatic ductal adenocarcinoma

scientific article

Asymmetric rhenium tricarbonyl complexes show superior luminescence properties in live cell imaging.

scientific article published on 23 December 2016

Automated identification of subcellular organelles by coherent anti-stokes Raman scattering.

scientific article published on May 2014

Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing

scientific article published on 16 November 2016

Circular RNA expression in basal cell carcinoma.

scientific article

Circular RNA expression in cutaneous squamous cell carcinoma

scientific article

Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients.

scientific article

Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma

scientific article published on 14 September 2012

Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for primary central nervous system lymphoma

scientific article published on 6 August 2015

Circulating U2 small nuclear RNA fragments as a novel diagnostic tool for patients with epithelial ovarian cancer.

scientific article

Clinical and genetic analysis of 18 pancreatic carcinoma/melanoma-prone families

scientific article published on 22 December 2009

Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases, and benign melanocytic nevi.

scientific article

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

scientific article (publication date: 19 January 1996)

DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression

scientific article published on 01 May 1999

Differential proteome analysis of colon carcinoma cell line SW480 after reconstitution of the tumour suppressor Smad4.

scientific article published on 17 October 2006

Discarding duplicate ditags in LongSAGE analysis may introduce significant error

scientific article

Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5).

scientific article

EU Pancreas: an integrated European platform for pancreas cancer research--from basic science to clinical and public health interventions for a rare disease

scientific article published in January 2013

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

scientific article published on 01 July 1996

Evaluation of the 4q32-34 locus in European familial pancreatic cancer.

scientific article published on October 2006

Expression of microRNAs in basal cell carcinoma.

scientific article

Expression profiles of long noncoding RNAs in cutaneous squamous cell carcinoma

scientific article published on 12 April 2016

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

scientific article

Gene expression analysis of cell death induction by taurolidine in different malignant cell lines

scientific article published on 30 October 2010

Genetics of hereditary pancreatic carcinoma

scientific article published on 01 March 2005

German National Case Collection of Familial Pancreatic Cancer – Clinical-Genetic Analysis of the First 21 Families

article

Global microRNA expression profiling of microdissected tissues identifies miR-135b as a novel biomarker for pancreatic ductal adenocarcinoma

scientific article published on 19 November 2011

HNPCC-associated small bowel cancer: clinical and molecular characteristics

scientific article published on 01 March 2005

HNPCC: six new pathogenic mutations

scientific article

High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition

scientific article

Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region.

scientific article

In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging

scientific article published on 14 July 2015

Induction of pancreatic cancer cell migration by an autocrine epidermal growth factor receptor activation.

scientific article published on 5 May 2014

Innovative substance 2250 as a highly promising anti-neoplastic agent in malignant pancreatic carcinoma - in vitro and in vivo

scientific article

Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε. ⬇️

scientific article

Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells

scientific article

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells

scientific article published on 26 June 2015

Lentiviral overexpression of miRNAs

scientific article published on January 2014

Long-noncoding RNAs in basal cell carcinoma.

scientific article published on 09 February 2016

Low frequency of CHEK2 mutations in familial pancreatic cancer

scientific article published on 20 July 2006

Manual microdissection combined with antisense RNA-longSAGE for the analysis of limited cell numbers

scientific article

MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL.

scientific article published on 27 January 2012

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.

scientific article published on 26 August 2015

MicroRNA-30c as a novel diagnostic biomarker for primary and secondary B-cell lymphoma of the CNS.

scientific article

MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma

scientific article published on 23 June 2012

Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine

scientific article published on 01 October 2003

Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts

scientific article (publication date: 2013)

Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors

scientific article published on 01 April 1999

New insights in the composition of extracellular vesicles from pancreatic cancer cells: implications for biomarkers and functions

scientific article published on 18 November 2014

Norepinephrine inhibits the migratory activity of pancreatic cancer cells.

scientific article published on 29 April 2013

Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets

scientific article

Prevalence of familial pancreatic cancer in Germany

scientific article published in July 2004

Quantitative RT-PCR specific for precursor and mature miRNAs

scientific article published on 01 January 2014

RNASEL germline variants are associated with pancreatic cancer

scientific article published on 01 December 2005

Raman micro-spectroscopy monitors acquired resistance to targeted cancer therapy at the cellular level

scientific article published in Scientific Reports

Recent discoveries in cancer genetics of exocrine pancreatic neoplasia

scientific article published on 01 August 1998

Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.

scientific article

Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models

scientific article published on 16 July 2021

Smad4 deficiency in cervical carcinoma cells.

scientific article

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

scientific article

Suppression of soluble adenylyl cyclase protects smooth muscle cells against oxidative stress-induced apoptosis.

scientific article

The Pancreatic Expression database: 2011 update

scientific article

The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells

scientific article

The pancreatic expression database: recent extensions and updates

scientific article

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

scientific journal article

Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions

scientific article published on 01 October 2005

Tumor suppressor Smad4 mediates downregulation of the anti-adhesive invasion-promoting matricellular protein SPARC: Landscaping activity of Smad4 as revealed by a "secretome" analysis.

scientific article

Unveiling of miRNA Expression Patterns in Purkinje Cells During Development

scientific article

Update of Familial Pancreatic Cancer in Germany

article

[S3-Guidelines "Exocrine pancreatic cancer" 2007]

scientific article published on 01 June 2007

aRNA-longSAGE: a new approach to generate SAGE libraries from microdissected cells

scientific article

List of works by Stephan Hahn

A genetic roadmap of pancreatic cancer: still evolving

A microRNA-based test improves endoscopic ultrasound-guided cytologic diagnosis of pancreatic cancer.

A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding

A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.

A web-based platform for mining pancreatic expression datasets

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas ⬇️

Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis

Analysis of U2 small nuclear RNA fragments in the bile differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders

Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation

Anticipation in familial pancreatic cancer.

Application of fluorescence difference gel electrophoresis saturation labelling for the analysis of microdissected precursor lesions of pancreatic ductal adenocarcinoma

Asymmetric rhenium tricarbonyl complexes show superior luminescence properties in live cell imaging.

Automated identification of subcellular organelles by coherent anti-stokes Raman scattering.

Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing

Circular RNA expression in basal cell carcinoma.

Circular RNA expression in cutaneous squamous cell carcinoma

Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients.

Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma

Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for primary central nervous system lymphoma

Circulating U2 small nuclear RNA fragments as a novel diagnostic tool for patients with epithelial ovarian cancer.

Clinical and genetic analysis of 18 pancreatic carcinoma/melanoma-prone families

Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases, and benign melanocytic nevi.

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression

Differential proteome analysis of colon carcinoma cell line SW480 after reconstitution of the tumour suppressor Smad4.

Discarding duplicate ditags in LongSAGE analysis may introduce significant error

Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5).

EU Pancreas: an integrated European platform for pancreas cancer research--from basic science to clinical and public health interventions for a rare disease

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

Evaluation of the 4q32-34 locus in European familial pancreatic cancer.

Expression of microRNAs in basal cell carcinoma.

Expression profiles of long noncoding RNAs in cutaneous squamous cell carcinoma

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

Gene expression analysis of cell death induction by taurolidine in different malignant cell lines

Genetics of hereditary pancreatic carcinoma

German National Case Collection of Familial Pancreatic Cancer – Clinical-Genetic Analysis of the First 21 Families

Global microRNA expression profiling of microdissected tissues identifies miR-135b as a novel biomarker for pancreatic ductal adenocarcinoma

HNPCC-associated small bowel cancer: clinical and molecular characteristics

HNPCC: six new pathogenic mutations

High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition

Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region.

In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging

Induction of pancreatic cancer cell migration by an autocrine epidermal growth factor receptor activation.

Innovative substance 2250 as a highly promising anti-neoplastic agent in malignant pancreatic carcinoma - in vitro and in vivo

Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε. ⬇️

Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells

Lentiviral overexpression of miRNAs

Long-noncoding RNAs in basal cell carcinoma.

Low frequency of CHEK2 mutations in familial pancreatic cancer

Manual microdissection combined with antisense RNA-longSAGE for the analysis of limited cell numbers

MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL.

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.

MicroRNA-30c as a novel diagnostic biomarker for primary and secondary B-cell lymphoma of the CNS.

MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma

Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine

Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts

Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors

New insights in the composition of extracellular vesicles from pancreatic cancer cells: implications for biomarkers and functions

Norepinephrine inhibits the migratory activity of pancreatic cancer cells.

Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets

Prevalence of familial pancreatic cancer in Germany

Quantitative RT-PCR specific for precursor and mature miRNAs

RNASEL germline variants are associated with pancreatic cancer

Raman micro-spectroscopy monitors acquired resistance to targeted cancer therapy at the cellular level

Recent discoveries in cancer genetics of exocrine pancreatic neoplasia

Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.

Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models

Smad4 deficiency in cervical carcinoma cells.

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

Suppression of soluble adenylyl cyclase protects smooth muscle cells against oxidative stress-induced apoptosis.

The Pancreatic Expression database: 2011 update

The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells

The pancreatic expression database: recent extensions and updates

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions

Tumor suppressor Smad4 mediates downregulation of the anti-adhesive invasion-promoting matricellular protein SPARC: Landscaping activity of Smad4 as revealed by a "secretome" analysis.

Unveiling of miRNA Expression Patterns in Purkinje Cells During Development

Update of Familial Pancreatic Cancer in Germany