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List of works by Yuichiro Higashimoto

A kinetic study of the mechanism of conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase.

scientific article

A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes

scientific article published in June 2002

A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.

scientific article published in December 1997

Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor.

scientific article published on 28 August 2013

Advanced glycation end products evoke inflammatory reactions in proximal tubular cells via autocrine production of dipeptidyl peptidase-4

scientific article published on 26 July 2018

An improved anion-exchange high-performance liquid chromatography method for measuring oxidized form of LDLs in human plasma.

scientific article

Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences

scientific article

Blockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells.

scientific article

C-terminal unfolding of an amyloidogenicβ2-microglobulin fragment:ΔN6β2-microglobulin

scientific article published on 19 December 2014

Calcium-dependent interaction of S100B with the C-terminal domain of the tumor suppressor p53.

scientific article published in April 1999

Caveolin-1 interacts with protein phosphatase 5 and modulates its activity in prostate cancer cells.

scientific article published on 23 January 2013

Caveolin-1 is a competitive inhibitor of heme oxygenase-1 (HO-1) with heme: identification of a minimum sequence in caveolin-1 for binding to HO-1

scientific article published on 14 July 2011

Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension

scientific article published in PLoS ONE

Crystal structure of rat haem oxygenase-1 in complex with ferrous verdohaem: presence of a hydrogen-bond network on the distal side

scientific article

Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate. Conformational change of the distal helix during the heme cleavage reaction

scientific article

DNA Aptamer Raised against Advanced Glycation End Products Prevents Abnormalities in Electroretinograms of Experimental Diabetic Retinopathy.

scientific article published on 23 October 2015

DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy.

scientific article published on 29 April 2013

DNA aptamer raised against advanced glycation end products (AGEs) improves glycemic control and decreases adipocyte size in fructose-fed rats by suppressing AGE-RAGE axis.

scientific article published on 8 August 2014

DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice.

scientific article published on 10 February 2014

DNA aptamer raised against advanced glycation end products inhibits neointimal hyperplasia in balloon-injured rat carotid arteries.

scientific article published on 8 January 2014

Development of a heme sensor using fluorescently labeled heme oxygenase-1

scientific article published on 12 October 2012

Development of a monoclonal antibody-based ELISA system for glyceraldehyde-derived advanced glycation end products

scientific article published on 21 August 2015

Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

scientific article

Evaluation of in vitro properties of predicted kinases that phosphorylate serine residues within nuclear localization signal 1 of high mobility group box 1.

scientific article

Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction

scientific article published on 09 April 2020

Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE.

scientific article published on 8 January 2015

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

scientific article

Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

scientific article published on 01 July 2000

Hydroxylamine and hydrazine bind directly to the heme iron of the heme-heme oxygenase-1 complex

scientific article published on 01 July 2004

Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes.

scientific article

Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples

scientific article published on 13 August 2015

Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action.

scientific article

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

scientific article (publication date: 3 May 2001)

Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase

scientific article

Involvement of metals in enzymatic and nonenzymatic decomposition of C-terminal alpha-hydroxyglycine to amide: an implication for the catalytic role of enzyme-bound zinc in the peptidylamidoglycolate lyase reaction.

scientific article published in February 2009

Laminin receptor mediates anti-inflammatory and anti-thrombogenic effects of pigment epithelium-derived factor in myeloma cells

scientific article published on 14 December 2013

Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase

scientific journal article

Methylglyoxal-derived hydroimidazolone-1 evokes inflammatory reactions in endothelial cells via an interaction with receptor for advanced glycation end products

scientific article published in June 2017

Modifications on amphiphilicity and cationicity of unnatural amino acid containing peptides for the improvement of antimicrobial activity against pathogenic bacteria.

scientific article

Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen

scientific article published on September 2002

N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGE)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties

scientific article

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

scholarly article

Ovalbumin in developing chicken eggs migrates from egg white to embryonic organs while changing its conformation and thermal stability

scientific article published on 01 April 1999

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

scientific article published in July 2000

Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor

scientific article

Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor

scientific article published on 27 January 2017

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

scientific article

Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System.

scientific article

Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells.

scientific article

Pigment epithelium-derived factor inhibits caveolin-induced interleukin-8 gene expression and proliferation of human prostate cancer cells.

scientific article

Protective Role of PEDF-Derived Synthetic Peptide Against Experimental Diabetic Nephropathy

scientific article published on 23 May 2016

Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1.

scientific article published on 18 June 2013

RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy.

scientific article

RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice.

scientific article published on 6 November 2017

RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice

scientific article published on 8 February 2018

Reduction of oxaporphyrin ring of CO-bound α-verdoheme complexed with heme oxygenase-1 by NADPH-cytochrome P450 reductase

scientific article published on 26 November 2010

Selection of DNA Aptamer That Blocks the Fibrillogenesis of a Proteolytic Amyloidogenic Fragment of β2 m.

scientific article published on 28 September 2017

Side chain effect on ion channel characters of Aib rich peptides.

scientific article published in December 2001

Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase

scientific article

Structure-function relationship of model Aib-containing peptides as ion transfer intermembrane templates

scientific article published on 01 April 1999

TAP-independent presentation of CTL epitopes by Trojan antigens.

scientific article published in June 2001

The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.

scientific article

X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase

scientific article

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