List of works by Wilfried le Goff

A CYP7A promoter binding factor site and Alu repeat in the distal promoter region are implicated in regulation of human CETP gene expression

scientific article published on 16 February 2003

A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process

scientific article published on 22 July 2019

A new piece in the puzzling effect of n-3 fatty acids on atherosclerosis?

scientific article published on 22 May 2014

A novel cholesteryl ester transfer protein promoter polymorphism (-971G/A) associated with plasma high-density lipoprotein cholesterol levels. Interaction with the TaqIB and -629C/A polymorphisms

scientific article published in April 2002

ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I

scientific article

ABCG1: Not as good as expected?

scientific article published on 22 July 2011

Action of ciprofibrate in type IIb hyperlipoproteinemia: modulation of the atherogenic lipoprotein phenotype and stimulation of high-density lipoprotein-mediated cellular cholesterol efflux

scientific article published in August 2003

Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity

scientific article published on 23 September 2014

Adipose ABCG1: A potential therapeutic target in obesity?

scientific article

Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis

scientific article

Atheroprotective reverse cholesterol transport pathway is defective in familial hypercholesterolemia.

scientific article published on 28 April 2011

Atorvastatin reduces postprandial accumulation and cholesteryl ester transfer protein-mediated remodeling of triglyceride-rich lipoprotein subspecies in type IIb hyperlipidemia

scientific article published in November 2002

CETP deficiency due to a novel mutation in the CETP gene promoter and its effect on cholesterol efflux and selective uptake into hepatocytes

scientific article published on 26 February 2011

Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects

scientific article published on 5 December 2007

Cholesteryl ester flux from HDL to VLDL-1 is preferentially enhanced in type IIB hyperlipidemia in the postprandial state

scientific article published in October 2002

Cholesteryl ester transfer protein expression partially attenuates the adverse effects of SR-BI receptor deficiency on cholesterol metabolism and atherosclerosis

scientific article

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors

scientific article

Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.

scientific article published on 25 October 2007

Critical Role of the Human ATP-Binding Cassette G1 Transporter in Cardiometabolic Diseases

scientific article published on 2 September 2017

Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway

scientific article

Cyclosporin A traps ABCA1 at the plasma membrane and inhibits ABCA1-mediated lipid efflux to apolipoprotein A-I.

scientific article published on 9 September 2004

Dose-dependent action of atorvastatin in type IIB hyperlipidemia: preferential and progressive reduction of atherogenic apoB-containing lipoprotein subclasses (VLDL-2, IDL, small dense LDL) and stimulation of cellular cholesterol efflux

scientific article published in August 2002

Elevated CETP activity improves plasma cholesterol efflux capacity from human macrophages in women

scientific article published on 16 August 2012

Endogenous CETP activity as a predictor of cardiovascular risk: determination of the optimal range

scientific article

Extended-Release Niacin/Laropiprant Improves Overall Efficacy of Postprandial Reverse Cholesterol Transport

scientific article published on 17 December 2015

Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia.

scientific article published on 5 December 2012

Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study.

scientific article published on 27 July 2005

Functionality of postprandial larger HDL2 particles is enhanced following CETP inhibition therapy.

scientific article published on 4 January 2012

Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels

scientific article published on 31 January 2013

HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages

article

HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export

scientific article

Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome

scientific article published on 14 July 2016

Human ATP-binding cassette G1 controls macrophage lipoprotein lipase bioavailability and promotes foam cell formation

scientific article

Hypoalphalipoproteinemia and BRAF V600E Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease

scientific article published on 01 August 2018

Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI

scientific article published on 27 July 2011

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia

scientific article published on 17 May 2012

Identification of the cAMP-responsive enhancer of the murine ABCA1 gene: requirement for CREB1 and STAT3/4 elements

scientific article published on 22 December 2005

Identification of the first Tangier disease patient in Lebanon carrying a new pathogenic variant in ABCA1

scientific article published in 2018

Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial hypercholesterolemia

scientific article published on 15 February 2012

Improved plasma cholesterol efflux capacity from human macrophages in patients with hyperalphalipoproteinemia

scientific article published on 12 March 2014

Inhibition of CETP by torcetrapib attenuates the atherogenicity of postprandial TG-rich lipoproteins in type IIB hyperlipidemia

scientific article published on 19 October 2007

Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response

scientific article

Lipidomic approach provides new clues toward solving the mystery of accelerated atherosclerosis in diabetes

scientific article published on 11 June 2016

Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry

scientific article

Modulation of Gr1low monocyte subset impacts insulin sensitivity and weight gain upon high-fat diet in female mice.

scientific article published on 3 August 2017

Multitrait GWAS to connect disease variants and biological mechanisms

scientific article published on 30 August 2021

Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome

scientific article

Pharmacological modulation of cholesteryl ester transfer protein, a new therapeutic target in atherogenic dyslipidemia

scientific article published on January 2004

Physiologie du métabolisme des lipoprotéines

Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy.

scientific article

Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders

scientific article

Plasma cholesterol efflux capacity from human THP-1 macrophages is reduced in HIV-infected patients: impact of HAART

scientific article

Postprandial lipemia enhances the capacity of large HDL2 particles to mediate free cholesterol efflux via SR-BI and ABCG1 pathways in type IIB hyperlipidemia

scientific article

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

scientific article

Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.

scientific article published on 19 June 2015

Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis

scientific article published on 7 October 2005

Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37.

scientific article published on May 2003

Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities.

scientific article published on 3 October 2013

Stimulation of cholesterol efflux by LXR agonists in cholesterol-loaded human macrophages is ABCA1-dependent but ABCG1-independent

scientific article published on 3 September 2009

Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis

scientific article published on 01 March 2020

The spectrum of neutrophilic dermatoses associated with monoclonal gammopathy: Association with IgA isotype and inflammatory profile

scientific article published on 11 September 2015

Therapeutic applications of reconstituted HDL: When structure meets function

scientific article

Torcetrapib differentially modulates the biological activities of HDL2 and HDL3 particles in the reverse cholesterol transport pathway

scientific article

Transcriptome profile of macrophages from atherosclerosis-sensitive and atherosclerosis-resistant mice

scientific article published on 03 March 2006

Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection

scientific article

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