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List of works by Edward Rebar

A TALE nuclease architecture for efficient genome editing

scientific article

A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.

scientific article

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

scientific article

A rapid and general assay for monitoring endogenous gene modification

scientific article

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease

scientific article published on 01 July 2019

An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice.

scientific article

An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

scientific article published on December 2010

An improved zinc-finger nuclease architecture for highly specific genome editing

scientific article

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

scientific article published on 5 May 2015

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

scientific article published on 2 March 2015

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

scientific article

Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics

scientific article

Designed transcription factors as tools for therapeutics and functional genomics

scientific article

Development of pro-angiogenic engineered transcription factors for the treatment of cardiovascular disease

scientific article published on July 2004

Diversifying the structure of zinc finger nucleases for high-precision genome editing

scientific article published on 08 March 2019

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. ⬇️

scientific article

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

scientific article (publication date: September 2009)

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

scientific article

Enhancing gene editing specificity by attenuating DNA cleavage kinetics

scientific article published on 29 July 2019

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

scientific article (publication date: July 2008)

Functional footprinting of regulatory DNA.

scientific article published on 31 August 2015

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

scientific article

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.

scientific article published on 06 July 2016

Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.

scientific article published on June 2006

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

scientific article published on 14 July 2011

Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application

scientific article published on 23 February 2016

Genetic engineering of human pluripotent cells using TALE nucleases

scientific article (publication date: 7 July 2011)

Genome editing with engineered zinc finger nucleases

scientific article

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

scientific article

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells

scientific article

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

scientific article published on 23 March 2015

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

scientific article

In vivo genome editing restores haemostasis in a mouse model of haemophilia

scientific article (publication date: 26 June 2011)

Knockout rats via embryo microinjection of zinc-finger nucleases

scientific article

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells

scientific article published on 11 January 2017

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

scientific article published on 15 March 2016

Mammalian interspecies substitution of immune modulatory alleles by genome editing

scientific article published on 22 February 2016

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

scientific article published on 24 February 2014

Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

scientific article published on 7 January 2016

Novel approaches to controlling transcription.

scientific article

PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis ⬇️

scientific article published on January 1, 2002

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

scientific article (publication date: 21 May 2009)

Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells ⬇️

scientific article published on February 6, 2011

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors

scientific article (publication date: 15 December 2003)

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

scholarly article

Targeted genome editing across species using ZFNs and TALENs

scientific article

Targeted transgene integration in plant cells using designed zinc finger nucleases

scientific article

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

scientific article published on 05 June 2013

Translating dosage compensation to trisomy 21

scientific article

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