Search filters

List of works by Robert C. Stein

A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer.

scientific article published on March 2006

A Phase II study to assess the safety and efficacy of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER positive locally advanced or metastatic breast cancer patients (IRIS) – Trial Results

A double-blind study of the efficacy of metronidazole gel in the treatment of malodorous fungating tumours.

scientific article

A preliminary clinical study of gossypol in advanced human cancer

scientific article published on 01 January 1992

A randomised study of carboplatin vs sequential ifosfamide/carboplatin for patients with FIGO stage III epithelial ovarian carcinoma. The London Gynaecologic Oncology Group. ⬇️

scientific article

AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial

Abstract OT3-17-01: OPTIMA: A prospective randomized trial to validate the clinical utility and cost-effectiveness of gene expression test-directed chemotherapy decisions in mostly node-positive early breast cancer

Abstract OT3-32-01: OPTIMA, a prospective randomized trial to validate the clinical utility and cost-effectiveness of gene expression test-directed chemotherapy decisions in high clinical risk early breast cancer

Abstract P4-11-07: Comparison of multiparameter tests in the UK OPTIMA-Prelim trial

Abstract P6-08-11: UK OPTIMA-prelim study demonstrates economic value in more clinical evaluation of multi-parameter prognostic tests in early breast cancer

Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer in the randomised UK TACT2 trial (CRUK/05/19): a multicentre, phase 3, open-label, randomised, c ⬇️

article

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

scientific article

Adaptive designs for clinical trials assessing biomarker-guided treatment strategies.

scientific article published on 25 March 2014

An adaptive biomarker strategy clinical trial design.

scientific article published on 29 November 2013

An endocrine and pharmacokinetic study of four oral doses of formestane in postmenopausal breast cancer patients

scientific article published on 01 January 1992

An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment.

scientific article

Aromatization inhibition alone or in combination with GnRH agonists for the treatment of premenopausal breast cancer patients.

scientific article

Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial

scientific article published on 16 December 2019

Clinical oncology: case presentations from oncology centres. 1. Ewing's sarcoma. The London Bone Tumour Service

scientific article published on 01 January 1991

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

scientific article

Cluster analysis of an extensive human breast cancer cell line protein expression map database

scientific article (publication date: February 2002)

Combinatorial use of mRNA and two-dimensional electrophoresis expression data to choose relevant features for mass spectrometric identification

scientific article

Comparative survival analysis of multiparametric tests—when molecular tests disagree—A TEAM Pathology study

Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others

scientific article published on 29 April 2016

Comparison of ondansetron with dexamethasone and domperidone in the prophylaxis of non-cisplatin chemotherapy induced emesis refractory to dexamethasone

scientific article published on 01 January 1991

Computational approaches to support comparative analysis of multiparametric tests: Modelling versus Training

scientific article published on 03 September 2020

Conveying Equipoise during Recruitment for Clinical Trials: Qualitative Synthesis of Clinicians' Practices across Six Randomised Controlled Trials.

scientific article published on 18 October 2016

Correction to: IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients. ⬇️

scientific article published on 25 October 2017

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Development of a framework to improve the process of recruitment to randomised controlled trials (RCTs): the SEAR (Screened, Eligible, Approached, Randomised) framework.

scientific article published on 19 January 2018

Discrepancies in central review re-testing of patients with ER-positive and HER2-negative breast cancer in the OPTIMA prelim randomised clinical trial.

scientific article published on 21 February 2017

Economic evaluation of genomic test-directed chemotherapy for early-stage lymph node-positive breast cancer ⬇️

scientific article

Efficient design of a phase III trial of competing tests for personalised cancer treatment in the absence of gold standard outcome data: challenges and potential solutions

scientific article published on 29 November 2013

Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts

scientific article

Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.

scientific article published on April 2007

HER2 testing for breast carcinoma: recommendations for rapid diagnostic pathways in clinical practice.

scientific article published on 23 September 2013

Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity

scientific article

Hyperpolarised 13C MRI: a new horizon for non-invasive diagnosis of aggressive breast cancer

scientific article published on 15 May 2019

IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients ⬇️

scientific article published in September 2017

Informed consent in randomised controlled trials: development and preliminary evaluation of a measure of Participatory and Informed Consent (PIC).

scientific article

Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.

scientific article

Lactic acidosis. A presentation of metastatic breast cancer arising in pregnancy.

scientific article published on January 1992

Macroscopic handling and reporting of breast cancer specimens pre- and post-neoadjuvant chemotherapy treatment: review of pathological issues and suggested approaches.

scientific article

Mitozantrone and methotrexate chemotherapy with and without mitomycin C in the treatment of advanced breast cancer: a randomised clinical trial

scientific article published on 01 January 1992

Models of breast cancer: is merging human and animal models the future?

scientific article

OP66 Tumor Profiling Tests In Early Breast Cancer: A Systematic Review

OPTIMA (Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis): A prospective trial to validate the predictive utility and cost-effectiveness of gene expression test-directed chemotherapy decisions

OPTIMA (Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis): A prospective trial to validate the predictive utility and cost-effectiveness of gene expression test-directed chemotherapy decisions

OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer

scientific article published in February 2016

OPTIMA: a prospective randomised trial to validate the predictive utility and cost-effectiveness of gene expression test-directed chemotherapy decisions

PI3-kinase inhibition: a target for drug development?

scientific article

Patient Pictures: Breast Cancer

Pharmacokinetics and pharmacodynamics of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione in patients with postmenopausal breast cancer ⬇️

scientific article published on January 1, 1991

Phase I/II study of the anti-oestrogen zindoxifene (D16726) in the treatment of advanced breast cancer. A Cancer Research Campaign Phase I/II Clinical Trials Committee study

scientific article

Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin

scientific article published on June 2000

Practicalities of using an adaptive design for decision making within the optima trial: optimal personalized treatment of early breast cancer using multi-parameter tests.

scientific article published on 16 November 2015

Predictors of ovarian reserve in young women with breast cancer

scientific article published on 29 May 2007

Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor-Positive Early Breast Cancer: PALLET Trial

scientific article published on 06 December 2018

SH2 and SH3 Domains: Unraveling Signaling Networks with Peptide Antagonists

scientific article published on January 1, 1998

Selecting breast cancer patients for chemotherapy: the opening of the UK OPTIMA trial.

scientific article published on 23 December 2012

Structural and functional diversity of phosphoinositide 3-kinases.

scientific article published on February 1996

The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene

scientific article

The Quintet Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation

scientific article published on 16 October 2018

The application of 2D gel-based proteomics methods to the study of breast cancer.

scientific article

The use of early decision modelling and value of information analysis in an adaptive trial design: results from the OPTIMA preliminary study.

scientific article published on 16 November 2015

Three-dimensional in vitro tissue culture models of breast cancer-- a review.

scientific article published on June 2004

Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/breast international group 03-05 study.

scientific article

Trastuzumab beyond progression: overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer

scientific article published on 07 July 2011

Treatment of advanced breast cancer in postmenopausal women with 4-hydroxyandrostenedione

scientific article published on 01 January 1990

Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: a systematic review and economic analysis

scientific article published on 01 June 2019

Tumour-stromal interactions in breast cancer: the role of stroma in tumourigenesis.

scientific article

Using adaptive designs for decision making within the optima trial: optimal personalized treatment of early breast cancer using multi-parameter tests

scientific article published on 29 November 2013

Value of Information Analysis of Multiparameter Tests for Chemotherapy in Early Breast Cancer: The OPTIMA Prelim Trial ⬇️

scientific article published on 11 July 2017

Viewpoint: Availability of oestrogen receptor and HER2 status for the breast multidisciplinary meeting discussion; time to get it right.

scientific article

p110δ, a novel phosphoinositide 3-kinase in leukocytes

scientific article

Paulina is supported by:

About Paulina

Help