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List of works by José C García-Borrón

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Melanocortin-1 receptor structure and functional regulation.

scientific article
Molecular anatomy of tyrosinase and its related proteins: beyond the histidine-bound metal catalytic center.

scientific article
Regulation of mammalian melanogenesis. I: Partial purification and characterization of a dopachrome converting factor: dopachrome tautomerase

scientific journal article
Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology.

scientific article published on September 2006
MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation

scientific article published on 30 May 2014
Identification of active site residues involved in metal cofactor binding and stereospecific substrate recognition in Mammalian tyrosinase. Implications to the catalytic cycle.

scientific article published in January 2002
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase

scientific article
Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.

scientific article
Agonist-independent, high constitutive activity of the human melanocortin 1 receptor.

scientific article published on August 2004
Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi

scientific article
Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients.

scientific article published on May 2009
Regulation of the final phase of mammalian melanogenesis. The role of dopachrome tautomerase and the ratio between 5,6-dihydroxyindole-2-carboxylic acid and 5,6-dihydroxyindole

scientific article published on August 15, 1992
Anti-inflammatory and anti-invasive effects of α-melanocyte-stimulating hormone in human melanoma cells

scientific article published on November 17, 2003
MC1R variants increased the risk of sporadic cutaneous melanoma in darker‐pigmented Caucasians: A pooled‐analysis from the M‐SKIP project

scientific article published on June 18, 2014
Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer

scientific article published on 27 November 2006
Thr40 and Met122 are new partial loss-of-function natural mutations of the human melanocortin 1 receptor.

scientific article
Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal

scientific article published on 29 January 2009
Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.

scientific article published on December 2002
Tyrosinase isoenzymes in mammalian melanocytes. 1. Biochemical characterization of two melanosomal tyrosinases from B16 mouse melanoma

scientific article published on 01 October 1993
The mouse silver locus encodes a single transcript truncated by the silver mutation.

scientific article published in December 1999
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas

scientific article
The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis.

scientific article published on 10 July 2013
MC1R signaling. Intracellular partners and pathophysiological implications

scientific article published on March 2017
Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma

scientific journal article
A new spectrophotometric assay for dopachrome tautomerase

scientific article published on 01 June 1990
New insights on the structure of the mouse silver locus and on the function of the silver protein

scientific article published on 01 January 2000
Apoptosis and molecular pathways in the seminiferous epithelium of aged and photoinhibited Syrian hamsters (Mesocricetus auratus).

scientific article published on 6 September 2006
Improved tyrosinase activity stains in polyacrylamide electrophoresis gels

scientific article published on 01 December 1993
Functional status and relationships of melanocortin 1 receptor signaling to the cAMP and extracellular signal-regulated protein kinases 1 and 2 pathways in human melanoma cells.

scientific article
Comparative action of dopachrome tautomerase and metal ions on the rearrangement of dopachrome

scientific article published on 01 November 1991
A three-dimensional model of mammalian tyrosinase active site accounting for loss of function mutations

scientific article published on 01 October 2007
Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN.

scientific article published in January 2003
Regulation of mammalian melanogenesis. II: The role of metal cations

scientific article published on 01 September 1990
The Pro162 variant is a loss-of-function mutation of the human melanocortin 1 receptor gene

scientific article published on 01 July 2001
Dopachrome tautomerase decreases the binding of indolic melanogenesis intermediates to proteins

scientific article published on 01 January 1994
Differential and competitive regulation of human melanocortin 1 receptor signaling by β-arrestin isoforms

scientific article published on June 7, 2013
The melanogenic system of Xenopus laevis

scientific article published on 01 October 1998
Molecular basis of the extreme dilution mottled mouse mutation: a combination of coding and noncoding genomic alterations

scientific journal article
Alpha-MSH and other melanogenic activators mediate opposite effects on tyrosinase and dopachrome tautomerase in B16/F10 mouse melanoma cells

scientific article published on 01 October 1992
Functional interplay between secreted ligands and receptors in melanoma

scientific article published on July 2017
Association of Melanocortin-1 Receptor Variants with Pigmentary Traits in Humans: A Pooled Analysis from the M-Skip Project

scientific article published on 29 May 2016
MC1R variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled analysis from the M-SKIP project.

scientific article published on 14 May 2018
Effect of detergents and endogenous lipids on the activity and properties of tyrosinase and its related proteins

scientific article published on 01 April 1995
Tyrosinase isoenzymes in mammalian melanocytes. 2. Differential activation by alpha-melanocyte-stimulating hormone

scientific article published on 01 October 1993
N‐glycosylation of the human melanocortin 1 receptor: occupancy of glycosylation sequons and functional role

scientific article published on April 5, 2011
Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies

scientific article published on August 3, 2012
Partial characterization of IR-alpha-MSH peptides found in melanoma tumors

scientific article published on September 1, 1992
Melanocortin 1 receptor and skin pathophysiology: beyond colour, much more than meets the eye

scientific article published on 01 June 2014
Quantitative determination of tryptophanyl and tyrosyl residues of proteins by second-derivative fluorescence spectroscopy

scientific article published on 01 September 1982
cAMP-independent non-pigmentary actions of variant melanocortin 1 receptor: AKT-mediated activation of protective responses to oxidative DNA damage

article

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