List of works - Lokesh Gakhar

Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

scientific article published on 22 September 2017

CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

scientific article published on 20 May 2015

Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

scientific article

Crystal structure of a complex of NOD1 CARD and ubiquitin

scientific article

Crystallization and preliminary X-ray diffraction analysis of naphthalene dioxygenase from Rhodococcus sp. strain NCIMB 12038.

scientific article published on 23 November 2002

Delineation of the caffeine C-8 oxidation pathway in Pseudomonas sp. strain CBB1 via characterization of a new trimethyluric acid monooxygenase and genes involved in trimethyluric acid metabolism. ⬇️

scientific article published on 18 May 2012

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions

scientific article published on 27 October 2016

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

scientific article published on May 2009

Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease.

scientific article

Free energy simulations of active-site mutants of dihydrofolate reductase

scientific article

Functional characterization of a cancer causing mutation in human replication protein A

scientific article

High-resolution structure of the Tiam1 PHn-CC-Ex domain

scientific article

Interaction of aryl hydrocarbon receptor-interacting protein-like 1 with the farnesyl moiety

scientific article published on 04 June 2013

Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

scientific article published on 11 September 2019

Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant Dandy-Walker malformation and occipital cephaloceles

scientific article published on 28 May 2013

Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

scientific article published on 25 October 2016

Novel, Highly Specific N -Demethylases Enable Bacteria To Live on Caffeine and Related Purine Alkaloids ⬇️

scientific article published on February 10, 2012

Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin

scientific article

PLUNC is a novel airway surfactant protein with anti-biofilm activity

scientific article

PLUNC: a multifunctional surfactant of the airways

scientific article published on August 2011

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

scientific article published on 16 September 2014

Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay

scientific article published on 16 September 2011

Rieske business: structure-function of Rieske non-heme oxygenases.

scientific article

Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.

scientific article

SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection

scientific article

Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.

scientific article published on 26 July 2016

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

scientific article

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

scientific article

Structural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachment

scientific article

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

scientific article published on 12 July 2019

Structure and increased thermostability of Rhodococcus sp. naphthalene 1,2-dioxygenase.

scientific article

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation

scientific article

The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains

scientific article

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

scientific article

The solution structure of the transducin-α-uncoordinated 119 protein complex suggests occlusion of the Gβ₁γ₁-binding sites

scientific article

The structure of LsrB from Yersinia pestis complexed with autoinducer-2 ⬇️

scientific article published on November 29, 2011

Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.

scientific article published on 24 July 2017

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

scientific article

List of works by Lokesh Gakhar

Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

Crystal structure of a complex of NOD1 CARD and ubiquitin

Crystallization and preliminary X-ray diffraction analysis of naphthalene dioxygenase from Rhodococcus sp. strain NCIMB 12038.

Delineation of the caffeine C-8 oxidation pathway in Pseudomonas sp. strain CBB1 via characterization of a new trimethyluric acid monooxygenase and genes involved in trimethyluric acid metabolism. ⬇️

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease.

Free energy simulations of active-site mutants of dihydrofolate reductase

Functional characterization of a cancer causing mutation in human replication protein A

High-resolution structure of the Tiam1 PHn-CC-Ex domain

Interaction of aryl hydrocarbon receptor-interacting protein-like 1 with the farnesyl moiety

Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant Dandy-Walker malformation and occipital cephaloceles

Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

Novel, Highly Specific N -Demethylases Enable Bacteria To Live on Caffeine and Related Purine Alkaloids ⬇️

Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin

PLUNC is a novel airway surfactant protein with anti-biofilm activity

PLUNC: a multifunctional surfactant of the airways

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay

Rieske business: structure-function of Rieske non-heme oxygenases.

Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.

SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection

Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

Structural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachment

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

Structure and increased thermostability of Rhodococcus sp. naphthalene 1,2-dioxygenase.

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation

The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

The solution structure of the transducin-α-uncoordinated 119 protein complex suggests occlusion of the Gβ₁γ₁-binding sites

The structure of LsrB from Yersinia pestis complexed with autoinducer-2 ⬇️

Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins