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List of works by Dirk Beher

3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.

scientific article published on 6 May 2006

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

scientific article published in January 2013

Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

scientific article published on February 2007

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

scientific article published on 23 November 2005

Cyclic sulfamide gamma-secretase inhibitors.

scientific article published in October 2005

Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by us

scientific article published in June 2003

Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.

scientific article published on 27 September 2012

Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.

scientific article published on 2 July 2012

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

scientific article (publication date: 2004)

Fatty acids increase presenilin-1 levels and [gamma]-secretase activity in PSwt-1 cells.

scientific article published on 16 September 2004

Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease.

scientific article

Gamma-secretase complex assembly within the early secretory pathway

scientific article

Gamma-secretase modulation and its promise for Alzheimer's disease: a rationale for drug discovery.

scientific article published on January 2008

Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400

scientific article published on 07 October 2013

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

scientific article

Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

scientific article published on 3 July 2001

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

scientific article published in July 2003

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

scientific article

Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease

scientific article published on 30 March 2012

Novel non-carbohydrate O-GlcNAcase inhibitors with CNS drug properties as potential treatment for Alzheimer’s disease and tauopathies.

scientific article published on 13 September 2013

Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia.

scientific article

Reactive oxygen species and Alzheimer's disease.

scientific article published on September 1997

Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines.

scientific article published on January 1996

Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.

scientific article

Resveratrol is not a direct activator of SIRT1 enzyme activity

scientific article

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

scientific article

Selective modulation of Abeta42 production in Alzheimer's disease: non-steroidal anti-inflammatory drugs and beyond.

scientific article published on January 2006

Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.

scientific article published on 18 January 2013

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

scientific article

The beta A4 amyloid precursor protein binding to copper.

scientific article published on July 1994

The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation

scientific article published on 3 December 2012

gamma-Secretase as a target for drug intervention in Alzheimer's disease.

scientific article published in September 2004

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.

scientific article published on 29 January 2003

gamma-Secretase inhibitors--from molecular probes to new therapeutics?

scientific article

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