List of works - Pang-hsien Tu

A combined DNA-affinic molecule and N-mustard alkylating agent has an anti-cancer effect and induces autophagy in oral cancer cells.

scientific article published on 9 March 2012

A hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic ALS in Taiwan

scientific article published on 5 June 2012

A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain.

scientific article published on 18 April 2013

Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content

scientific journal article

An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice

scientific article

Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway.

scientific article published on 22 December 2010

Cerebellar anaplastic pilocytic astrocytoma in a patient of neurofibromatosis type-1: case report and review of the literature.

scientific article published on 06 March 2012

Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response.

scientific article

Exome sequencing identifies GNB4 mutations as a cause of dominant intermediate Charcot-Marie-Tooth disease.

scientific article published on 21 February 2013

FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS.

scientific article

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

scientific article published on 12 September 2014

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

scientific article published in September 1998

Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer.

scientific article

Inhibition of TDP-43 aggregation by nucleic acid binding

scientific article

Intranasal Administration of a Polyethylenimine-Conjugated Scavenger Peptide Reduces Amyloid-β Accumulation in a Mouse Model of Alzheimer's Disease

scientific article published on 18 June 2016

Mice with disrupted midsized and heavy neurofilament genes lack axonal neurofilaments but have unaltered numbers of axonal microtubules

scientific article published on 01 July 1999

Neurofilaments and Orthograde Transport Are Reduced in Ventral Root Axons of Transgenic Mice that Express Human SOD1 with a G93A Mutation ⬇️

scientific article published on December 1, 1997

Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation

scientific article published in January 2007

Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations

scientific article published on 01 June 2006

Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

scientific article

OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma.

scientific article published in March 2005

Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma ⬇️

scientific article published on May 23, 2013

Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma ⬇️

scientific article published on November 1, 2010

Requirement of heavy neurofilament subunit in the development of axons with large calibers

scientific journal article

Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases

scientific article

Targeting autophagy enhances BO-1051-induced apoptosis in human malignant glioma cells.

scientific article

Targeting protective autophagy exacerbates UV-triggered apoptotic cell death

scientific article published on 20 January 2012

USP11 regulates PML stability to control Notch-induced malignancy in brain tumours.

scientific article published on January 2014

List of works by Pang-hsien Tu

A combined DNA-affinic molecule and N-mustard alkylating agent has an anti-cancer effect and induces autophagy in oral cancer cells.

A hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic ALS in Taiwan

A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain.

Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content

An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice

Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway.

Cerebellar anaplastic pilocytic astrocytoma in a patient of neurofibromatosis type-1: case report and review of the literature.

Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response.

Exome sequencing identifies GNB4 mutations as a cause of dominant intermediate Charcot-Marie-Tooth disease.

FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS.

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer.

Inhibition of TDP-43 aggregation by nucleic acid binding

Intranasal Administration of a Polyethylenimine-Conjugated Scavenger Peptide Reduces Amyloid-β Accumulation in a Mouse Model of Alzheimer's Disease

Mice with disrupted midsized and heavy neurofilament genes lack axonal neurofilaments but have unaltered numbers of axonal microtubules

Neurofilaments and Orthograde Transport Are Reduced in Ventral Root Axons of Transgenic Mice that Express Human SOD1 with a G93A Mutation ⬇️

Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation

Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations

Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma.

Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma ⬇️

Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma ⬇️

Requirement of heavy neurofilament subunit in the development of axons with large calibers

Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases

Targeting autophagy enhances BO-1051-induced apoptosis in human malignant glioma cells.

Targeting protective autophagy exacerbates UV-triggered apoptotic cell death

USP11 regulates PML stability to control Notch-induced malignancy in brain tumours.