List of works by David M. Holtzman

"Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia"

scientific article published on 01 January 2019

11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorder

scientific article published on January 2012

18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery

scientific article published in February 2018

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

scientific article published on 17 June 2020

A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor

scientific article published on 01 July 1996

A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system

scientific article published on July 2009

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

scientific article published in November 1997

A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin

scientific article published on 25 September 2015

A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects

scientific article published on 17 June 2016

A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum

scientific article

A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo.

scientific article published on October 1997

A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

scientific article published on 7 March 2016

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

scientific article published on 09 August 2019

A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease

scientific article published on 9 November 2015

A surrogate marker for Abeta42 production in the CNS.

scientific article published on July 2009

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

scientific article

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

scientific article published on 17 April 2017

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

scientific article

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model.

scientific article

APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

scientific article published on 31 January 2017

APOE genotype regulates pathology and disease progression in synucleinopathy

scientific article published on 01 February 2020

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

scientific article

Abeta conformational change is central to Alzheimer's disease

scientific article published in November 2002

Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease

scientific article

Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex

scientific article

Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report

scientific article published on December 2009

Active and passive immunotherapy for neurodegenerative disorders

scientific article

Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo

scientific article

Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity

scholarly article

Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis

scientific article published on February 2016

Age and amyloid effects on human central nervous system amyloid-beta kinetics

scientific article

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.

scientific article published in December 2017

Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.

scientific article published in August 2004

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

scientific article

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

scientific article

Altered sleep and EEG power in the P301S Tau transgenic mouse model

scientific article published on 15 February 2017

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction

scientific article

Alternatives to amyloid for Alzheimer's disease therapies-a symposium report

scientific article published on 29 May 2020

Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).

scientific article

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

scientific article published on 26 September 2019

Alzheimer disease biomarkers, attentional control, and semantic memory retrieval: Synergistic and mediational effects of biomarkers on a sensitive cognitive measure in non-demented older adults

scientific article

Alzheimer disease in 2020.

scientific article

Alzheimer disease: advances in pathogenesis, diagnosis, and therapy.

scientific article published on 10 February 2011

Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta).

scientific article published in February 2004

Alzheimer's Disease-Related Dementias Summit 2016: National research priorities

scientific article

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta

scientific article published on 24 September 2008

Alzheimer's disease: Moving towards a vaccine.

scientific article published in July 2008

Alzheimer's disease: the challenge of the second century

scientific article published on April 2011

Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals

scientific article published on 28 April 2016

Amyloid beta and Alzheimer disease therapeutics: the devil may be in the details

scientific article published on August 2003

Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice.

scientific article published in February 2001

Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later

scientific article published on 10 April 2013

Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis

scientific article

Amyloid-beta binding molecule: potential role in the pathogenesis and treatment of Alzheimer disease.

scientific article

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle

scientific article

Amyloid-beta dynamics correlate with neurological status in the injured human brain

scientific article published on August 2008

Amyloid-beta immunotherapies in mice and men.

scientific article published on April 2006

Amyloid-β 'seeds' in old vials of growth hormone

scientific article published on 01 December 2018

Amyloid-β and Tau at the Crossroads of Alzheimer's Disease

scientific article published on 01 January 2019

Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls

scientific article published on 7 December 2012

Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease

scientific article published on January 2012

Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD

scientific article

Analysis of in vivo turnover of tau in a mouse model of tauopathy

scientific article published on 26 October 2015

Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

scientific article

Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis

scientific article

Anti-Aβ antibody target engagement: commentary regarding Watt et al. Acta Neuropathol 127:803-810 (2014).

scientific article

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

scientific article

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

scientific article published on 26 September 2013

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

scientific article published on April 2017

Anti-tau antibody reduces insoluble tau and decreases brain atrophy

scientific article published on 23 January 2015

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease

scientific article published on 21 July 2016

Antibody Therapeutics Targeting Aβ and Tau.

scientific article published on 6 January 2017

Antisense reduction of tau in adult mice protects against seizures

scientific article published on July 2013

ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis

scientific journal article

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo

scientific article published in January 2004

ApoE facilitates the microglial response to amyloid plaque pathology.

scientific article published on 26 February 2018

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

scientific article published on 25 April 2013

ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

scientific article published on 12 January 2023

ApoE promotes the proteolytic degradation of Abeta

scientific article

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

scientific article published on 20 September 2017

ApoE4 upregulates the activity of mitochondria-associated ER membranes

scientific article

Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

scientific article published on 27 February 2017

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

scientific article

Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice

scientific article published on 29 September 2006

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

scientific article

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

scientific article published in June 2000

Apolipoprotein E in Alzheimer's disease and other neurological disorders

scientific article published on March 2011

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease ⬇️

scholarly article

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients

scientific article

Apolipoprotein E levels and Alzheimer risk

scientific article published on 21 January 2015

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms

scientific article published on 12 April 2007

Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice.

scientific article

Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease

scientific article

Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis

scientific article

Apolipoprotein E, amyloid, and Alzheimer disease

scientific article published on October 2002

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

scientific article

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein

scientific article published on November 1996

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

scientific article

Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease.

scientific article published in December 2002

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

scientific article published on 03 November 2020

Are CSF biomarkers ready for prime time as diagnostics for Alzheimer disease? Interview by Rebecca Voelker

scientific article published in November 2010

Assessment of Racial Disparities in Biomarkers for Alzheimer Disease

scientific article published on 01 March 2019

Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease

scientific article

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

scientific article published on 02 December 2019

Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo

scientific article

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition. ⬇️

scientific article published on 8 March 2017

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

scientific article

Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease

scientific article published on 14 May 2020

Author response.

scientific article published in February 2013

Autistic spectrum disorders and mitochondrial encephalopathies

scientific article

Automated selective disruption of slow wave sleep

scientific article published on 23 February 2017

B-RAF unlocks axon regeneration

scientific article

BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways

scientific article

BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease

scientific article

BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia

scientific article published on 01 February 2000

BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia.

scientific article published in November 2000

BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway

scientific article published on 01 August 2000

Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia

scientific article

Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons.

scientific article published in February 1998

Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal

scientific article

Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

scientific article published on August 2001

Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice ⬇️

scientific article published on November 8, 2010

Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain ⬇️

scientific article published in March 2012

Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors

scientific article published on 13 August 2019

Biomarker modeling of Alzheimer's disease

scientific article published on December 2013

Biomarkers in translational research of Alzheimer's disease

scientific article

Biomarkers of Alzheimer's disease

scientific article

Biomarkers will revolutionize the way we diagnose and treat Alzheimer's disease.

scientific article published in February 2010

Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.

scientific article

Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration

scientific article published on 13 March 2013

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

scientific article published on 19 October 2018

Brain ATP metabolism in hypoxia resistant mice fed guanidinopropionic acid.

scientific article published in January 1998

Brain creatine kinase and creatine transporter proteins in normal and creatine-treated rabbit pups

scientific article published in September 2000

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

scientific article published on 29 January 2018

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease

scientific article published in March 2002

CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease.

scientific article published on 22 February 2012

CSF biomarkers for Alzheimer's disease: current utility and potential future use.

scientific article published on December 2011

CSF biomarkers for secondary prevention trials: why markers of amyloid deposition and neurodegeneration are both important

scientific article published on 01 June 2012

CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease

scientific article

CSF biomarkers of Alzheimer disease: "noncognitive" outcomes

scientific article

CSF sTREM2: marking the tipping point between preclinical AD and dementia?

scientific article published on 14 March 2016

Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury

scientific article published on 6 October 2004

Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice

scientific article

Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain.

scientific article published in March 2005

Case records of the Massachusetts General Hospital. Case 36-2005. A 61-year-old woman with seizure, disturbed gait, and altered mental status

scientific article published in November 2005

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury

scientific article published on May 1998

Caspase-3 deficiency during development increases vulnerability to hypoxic-ischemic injury through caspase-3-independent pathways

scientific article published on 9 February 2006

Caspases: A treatment target for neurodegenerative disease? ⬇️

scientific article published on 01 September 1997

Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats

scientific article published on 15 December 2005

Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein

scientific article published in November 2002

Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice.

scientific article published in July 2008

Cerebral amyloid angiopathy increases susceptibility to infarction after focal cerebral ischemia in Tg2576 mice

scientific article

Cerebrospinal Fluid Biomarkers and Reserve Variables as Predictors of Future "Non-Cognitive" Outcomes of Alzheimer's Disease

scientific article published on 16 April 2016

Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease

scientific article

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

scientific article

Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity

scientific article published on October 2013

Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort

scientific article

Cerebrospinal fluid beta-amyloid 42, Tau, and P-tau: confirmation now realization

scientific article published on 01 December 2009

Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type

scientific article published on May 2009

Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging.

scientific article published in March 2018

Cerebrospinal fluid biomarkers of Alzheimer's disease

scientific article

Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus

scientific article

Cerebrospinal fluid biomarkers, education, brain volume, and future cognition

scientific article

Cerebrospinal fluid levels of amyloid precursor protein are associated with ventricular size in post-hemorrhagic hydrocephalus of prematurity

scientific article

Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type

scientific article published in October 2012

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

scientific article published on 11 January 2016

Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia

scientific article published in July 2003

Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease

scientific article

Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults

scientific article published on 8 January 2007

Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition

scientific article published on December 2008

Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence?

scientific article published on 18 July 2016

Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice

scientific article published on August 2009

Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40.

scientific article

Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease

scientific article

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

scientific article

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.

scientific article

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

scientific article

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunitie

scientific article published on 03 August 2020

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

scientific article

Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia

scientific article published in March 2001

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

scientific journal article

Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study

scientific article

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

scientific article

Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid

scientific article

Comparison of a single-channel EEG sleep study to polysomnography

scientific article published on 2 June 2016

Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology

scientific article

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

scientific article

Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities

scientific article

Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

scientific article published on 23 May 2017

Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Ratesin the CNS.

scientific article published on 3 July 2012

Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease

scientific article

Creatine increases survival and suppresses seizures in the hypoxic immature rat.

scientific article published in September 1998

Creatine kinase-catalyzed reaction rate in the cyanide-poisoned mouse brain

scientific article published in January 1993

Critical issues for successful immunotherapy in Alzheimer's disease: development of biomarkers and methods for early detection and intervention

scientific article published on April 2009

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

scientific article published in May 2011

Current thinking on the mechanistic basis of Alzheimer's and implications for drug development.

scientific article published on 06 August 2015

Deciphering Alzheimer disease

scientific article published on January 2012

Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly

scientific article published on February 2009

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

scientific article

Dementia is not synonymous with Alzheimer's disease

scientific article published on 01 December 2019

Depression and Alzheimer's Disease Biomarkers Predict Driving Decline

scientific article published on 01 January 2018

Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging

scientific article

Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury

scientific article published on 12 February 2007

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network

scientific article (publication date: October 2012)

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

scientific article published on November 1996

Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease

scientific article published on 28 March 2016

Dietary salt promotes cognitive impairment through tau phosphorylation

scientific article published on 23 October 2019

Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.

scientific article published in August 2000

Differential effects of cAMP in neurons and astrocytes. Role of B-raf

scientific article published on 01 September 1999

Differential metabolism of ApoE isoforms in plasma and CSF.

scientific article

Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain

scientific article

Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

scientific article

Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury

scientific article published on October 2007

Diseases of adenosine triphosphate synthesis in children

scientific article

Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology

scientific article published on September 2012

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake

scientific article

Diurnal oscillation of CSF Aβ and other AD biomarkers

scientific article

Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1

scientific article published on 11 February 2019

Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers

scientific article published on 9 January 2018

Dual therapy for Aβ amyloidosis in AD: A successful one-two combo.

scientific article published on 23 April 2018

Dural lymphatics regulate clearance of extracellular tau from the CNS

scientific article published on 27 February 2019

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation

scientific article

Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome ⬇️

scientific article published on February 1, 1992

Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents

scientific article published on 17 April 2008

Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy

scientific article published in January 2004

Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

scientific article published on 19 March 2015

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

scientific article published in February 2006

Effects of growth hormone-releasing hormone on sleep and brain interstitial fluid amyloid-β in an APP transgenic mouse model

scientific article

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

scientific article published on 12 June 2009

Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease

scientific article published in June 2013

Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury

scientific article published on April 2007

Elements in the 5' flanking sequences of the mouse low-affinity NGF receptor gene direct appropriate CNS, but not PNS, expression in transgenic mice.

scientific article published on May 1995

Elucidating the Role of TREM2 in Alzheimer's Disease

scientific article

Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice

scientific article published on 5 June 2012

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease

scientific article published on 04 March 2019

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

scientific article published on April 2008

Endogenous FGF-2 is important for cholinergic sprouting in the denervated hippocampus.

scientific article published on April 1997

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

scientific article published on 12 January 2017

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain ⬇️

scientific article published on October 1, 2003

Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system

scientific article

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury

scientific article published on June 1998

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

scientific article

Evidence that p38 mitogen-activated protein kinase contributes to neonatal hypoxic-ischemic brain injury

scientific article published in January 2002

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

scientific article published on January 2005

Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition

scientific article published on May 2012

Exercise and Alzheimer's disease biomarkers in cognitively normal older adults

scientific article

Expectations and challenges in the therapeutic use of neurotrophic factors

scientific article published on 01 March 2006

Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line

scientific article

Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility

scientific article

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

scientific article

Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF.

scientific article

Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation

scientific article published in May 2007

Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease

scientific article

Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker.

scientific article published in February 2007

Functional connectivity and graph theory in preclinical Alzheimer's disease

scientific article published on 18 October 2013

Functional connectivity in autosomal dominant and late-onset Alzheimer disease

scientific article

Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42

scientific article published on 08 October 2020

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease

scientific article

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits.

scientific article

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

scientific article published on 28 February 2017

Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation

scientific article

Glial contributions to neurodegeneration in tauopathies

scientific article

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

scientific article published in May 1998

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

scientific article published on 08 December 2016

Gut microbiota: from the forgotten organ to a potential key player in the pathology of Alzheimer disease

scientific article published on 18 November 2019

Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis

scientific article published on December 2011

High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture

scientific article published in March 1997

High-affinity interactions and signal transduction between Aβ oligomers and TREM2

scientific article published on 01 November 2018

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

scientific article published on 01 August 2019

How amyloid, sleep and memory connect

scientific article published on June 2015

Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma

scientific article

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

scientific article

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease

scientific article published on 13 January 2020

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

scientific article published in April 2002

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

scientific article

Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

scientific article

Human neurons derived from induced pluripotent stem cells as a new platform for preclinical drug screening and development

scientific article published in December 2014

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

scientific article published on 4 May 2015

Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease

article

Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease

scientific article (publication date: 12 January 2011)

Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study

scientific article published in September 2015

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

scientific article

Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease

scientific article published on 11 July 2016

Immigration in science

scientific article published on 01 November 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

scientific article published in May 2002

Immunization therapy for Alzheimer disease?

scientific article published on 01 January 2005

Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration

scientific article published on 16 June 2020

Impaired Autophagy in APOE4 Astrocytes

scientific article published on 25 February 2016

Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice

scientific journal article

Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease

scientific article

In Search of an Identity for Amyloid Plaques

scientific article published on 01 August 2018

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life ⬇️

scientific article published on October 1, 2003

In memoriam: William M. Landau, MD.

scientific article

In situ AFM studies of astrocyte-secreted apolipoprotein E- and J-containing lipoproteins.

scientific article published in October 2004

In situ atomic force microscopy study of Alzheimer's beta-amyloid peptide on different substrates: new insights into mechanism of beta-sheet formation

scientific article

In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease

scientific article

In vivo MRI analysis of an inflammatory injury in the developing brain.

scientific article

In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog.

scientific article published in May 1997

In vivo development of brain phosphocreatine in normal and creatine-treated rabbit pups

scientific article published on 01 December 1999

In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology

scientific article published on January 2004

In vivo human apolipoprotein E isoform fractional turnover rates in the CNS

scientific article (publication date: 2012)

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

scientific article published on 19 April 2013

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

scientific article

Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers

scientific article published on 01 November 2018

Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers

scientific article

Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

scholarly article

Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

scientific article published on 25 July 2018

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

scientific article published on 01 December 2018

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.

scientific article published on 30 April 2016

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

scientific article published in March 2006

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease

scientific article published on 23 October 2017

Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury

scientific article published on 14 April 2009

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

scientific article published on 17 October 2019

Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age.

scientific article

Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ɛ4 genotype.

scientific article published on 17 April 2018

Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease

scientific article

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

scientific article published on 14 September 2018

Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease.

scientific article published on 23 March 2018

Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology

scientific article published on 22 August 2016

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

scientific article published on 07 January 2019

Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression

scientific article

Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy

scientific article published in July 2007

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

scientific article

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.

scientific article

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

scientific article

Lumbar Cerebrospinal Fluid Biomarkers of Posthemorrhagic Hydrocephalus of Prematurity: Amyloid Precursor Protein, Soluble Amyloid Precursor Protein α, and L1 Cell Adhesion Molecule

scientific article published on 26 August 2016

Lumbosacral plexopathy secondary to perirectal abscess in a patient with HIV infection

scientific article published in October 1989

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation

scientific article

Mapping the road forward in Alzheimer's disease

scientific article published in December 2011

Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury

scientific article

Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury

scientific article published on 17 March 2005

Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy

scientific article

Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

scientific article

Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage

scientific article (publication date: 15 March 2005)

Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.

scientific article published in October 2006

Maturational changes in rabbit brain phosphocreatine and creatine kinase

scientific article published on 01 January 1999

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

scientific article

Mechanisms linking circadian clocks, sleep, and neurodegeneration

scientific article published on November 2016

Medicine. Prion-like behavior of amyloid-beta

scientific article

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

scientific article published on 28 April 2021

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

scientific article published on 10 October 2019

Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

scientific article

Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury

scientific article

Minocycline reduces spontaneous hemorrhage in mouse models of cerebral amyloid angiopathy

scientific article published on 5 May 2015

Missense variant in TREML2 protects against Alzheimer's disease

scientific article published on 21 December 2013

Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease

scientific article published on January 1, 1991

Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex

scientific article

Molecular studies in Alzheimer's disease

scientific article published on April 1991

Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels

scientific article published on 19 April 2016

Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury

scientific article published on 23 November 2005

Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants ⬇️

scientific article published on February 15, 1992

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey.

scientific article published on December 1990

Multi-Modal Home Sleep Monitoring in Older Adults

scientific article published on 26 January 2019

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

scientific article

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects

scientific article

Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis

scientific article (publication date: 19 April 2011)

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

scientific article published on 15 January 2022

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

scientific article

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.

scientific article published in April 2018

NIA-AA staging of preclinical Alzheimer disease: discordance and concordance of CSF and imaging biomarkers

scientific article published on 4 April 2016

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.

scientific article published on 30 August 2017

NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin ⬇️

scientific article published on November 1, 1994

Nascent astrocyte particles differ from lipoproteins in CSF.

scientific article published in May 1998

National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards

scientific article

Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic-ischemic injury.

scientific article published in February 1996

Nerve growth factor and the neurotrophic factor hypothesis

scientific article published on September 1996

Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein

scientific article published on May 1998

Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury

scientific article published on 01 January 1996

Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration

scientific article

Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome

scientific article published on January 1, 1992

Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease

scientific article

Neuronal activity regulates extracellular tau in vivo

scientific article published on 17 February 2014

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

scientific article

Neuronal clearance of amyloid-β by endocytic receptor LRP1.

scientific article

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease

scientific article

Neuropathology for the neuroradiologist: plaques and tangles

scientific article published on 09 October 2007

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.

scientific article

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

scientific article published on 18 December 2011

Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report

scientific article published on 28 April 2017

Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease

scientific article published on 14 April 2017

Neurotrophic factors and neurologic disease

scientific article

New insights into the role of TREM2 in Alzheimer's disease

scientific article published on 20 December 2018

New-onset seizures associated with human immunodeficiency virus infection: causation and clinical features in 100 cases

scientific article

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

scientific article published on 4 November 2011

Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning

scientific article published in March 1999

Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy

scientific article published on 06 May 2016

No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo

scientific article published on 01 July 2000

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

scientific article published on 24 August 2016

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses

scientific article

Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content

scientific article

Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid

scientific article published on 30 April 2016

Obstructive sleep apnea treatment, slow wave activity, and amyloid-β

scientific article published on 17 January 2019

Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo

scientific article published in August 2011

Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement

scientific article

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

scientific article published in February 2008

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

scientific article

Oxidative phosphorylation in immature rat brain mitochondria

scientific article published in January 1973

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

scientific article published on 20 October 2005

PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures

scientific article published on February 2003

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

scientific article published on 03 July 2001

Peripheral neuropathy associated with acquired immunodeficiency syndrome. Prevalence and clinical features from a population-based survey

scientific article

Phosphocreatine and ATP regulation in the hypoxic developing rat brain ⬇️

scientific article published on April 18, 1995

Phosphocreatine and creatine kinase in piglet cerebral gray and white matter in situ

scientific article published on 01 January 1996

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis

scientific article

Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid

scientific article

Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease

scientific article

Pittsburgh compound B retention and verification of amyloid deposition.

scientific article published in March 2007

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease

scientific article

Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia

scientific article published on December 2006

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease

scientific article

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

scientific article

Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.

scientific article

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease

scientific article published on 28 September 2006

Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury

scientific article

Potential Role of Endogenous and Exogenous Amyloid-Beta Binding Molecules in the Pathogenesis, Diagnosis, and Treatment of Alzheimer Disease ⬇️

scientific article published on July 1, 2003

Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system

scientific article published on August 1998

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease

scientific article

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease.

scientific article published in January 2015

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

scientific article published on 04 September 2013

Preclinical Alzheimer's disease and longitudinal driving decline

scientific article published on January 2017

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.

scientific article published in March 2016

Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies

scientific article published in January 2017

Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid

scientific article

Preliminary characterization of long-term reaggregating cultures of trisomy 16 central nervous system

scientific article published on January 1, 1992

Preliminary characterization of the central nervous system in partial trisomy 16 mice.

scientific article published on January 1995

Pretreatment with Human Chorionic Gonadotropin Protects the Neonatal Brain against the Effects of Hypoxic-Ischemic Injury

scientific article published on 3 November 2017

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta

scientific article

Profound, reversible energy loss in the hypoxic immature rat brain

scientific article published in May 1993

Progress update: fluid and imaging biomarkers in Alzheimer's disease

scientific article published on 05 September 2013

Proteopathic tau seeding predicts tauopathy in vivo.

scientific article

Publisher Correction: Dietary salt promotes cognitive impairment through tau phosphorylation

scientific article published on 01 February 2020

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

scientific article

Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry

scientific article published on 01 January 2006

Quantitative analysis of amyloid-beta peptides in cerebrospinal fluid using immunoprecipitation and MALDI-Tof mass spectrometry

scientific article

Quantitative label-free proteomics for discovery of biomarkers in cerebrospinal fluid: assessment of technical and inter-individual variation

scientific article

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

scientific article published on February 2008

Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice

scientific article published on December 2008

Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway

scientific article

Re-evaluation of the Blood-Brain Barrier in the Presence of Alzheimer's Disease Pathology

scientific article published in October 2015

Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease

scientific article published on 9 January 2015

Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease

scientific article published on 01 January 2019

Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

scientific article

Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons

scientific article

Regulation of amyloid-β dynamics and pathology by the circadian clock.

scientific article published on 30 January 2018

Relationship between Stroop performance and resting state functional connectivity in cognitively normal older adults

scientific article published on September 2013

Relationship of dementia screening tests with biomarkers of Alzheimer's disease ⬇️

scientific article published on September 7, 2010

Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain

scientific article

Reply

Reply

scientific article published on 27 January 2017

Reply to "obstructive sleep apnea treatment and amyloid-β in cerebrospinal fluid"

scientific article published on 19 February 2019

Reply to: Fractional synthesis and clearance rates for amyloid β

Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models

scientific article

Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

scientific article

Role of biomarkers in studies of presymptomatic Alzheimer's disease

scientific article published on October 2005

Role of caspase-3 in ethanol-induced developmental neurodegeneration

scientific article published on 31 May 2005

Role of family history for Alzheimer biomarker abnormalities in the adult children study

scientific article

Role of nerve growth factor in experimental autoimmune encephalomyelitis

scientific article published on 01 February 2001

Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity

scientific journal article

Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation

scientific article

SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury

scientific article published on 06 May 2020

SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus ⬇️

scientific article published on July 28, 2010

SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease

scientific article

SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy

scientific article published on February 2013

Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy.

scientific article published on November 1995

Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia.

scientific article published in January 2002

Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

scientific article

Senescent glia spell trouble in Alzheimer's disease

scientific article published on 01 May 2019

Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice.

scientific article published on 18 March 2015

Sleep and Alzheimer disease pathology--a bidirectional relationship

scientific article published on 24 December 2013

Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum

scientific article

Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a <i>TREM2</i> -dependent manner in mice

scientific article published on 26 April 2023

Sleep evaluation by actigraphy for patients with Alzheimer disease--reply

scientific article published in August 2013

Sleep in Alzheimer's Disease - Beyond Amyloid

scientific article published on 10 August 2016

Sleep quality and preclinical Alzheimer disease

scientific article published on May 2013

Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease

scientific article

Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

scientific article published in August 2017

Small Molecule Phenotypic Screen Identifies Novel Regulators of LDLR Expression

scientific article published on 03 December 2020

Soluble amyloid-beta, effect on cerebral arteriolar regulation and vascular cells

scientific article

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

scientific article published on 31 January 2018

Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates

scientific article

Stealth attack: plaque-specific antibody allows for efficient Aβ removal without side effects

scientific article published on 01 December 2012

Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain

scientific article

Supply and demand analysis of the current and future US neurology workforce

scientific article

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

scientific article published in December 2005

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading

scientific article published on 04 May 2020

TREM2 Function in Alzheimer's Disease and Neurodegeneration

scientific article published on 8 February 2016

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

scientific article published on August 2017

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

scientific article published on 09 August 2020

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

scientific article published on 9 October 2017

TREM2 function impedes tau seeding in neuritic plaques

scientific article published on 24 June 2019

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

scientific article published on 26 February 2015

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

scientific article published on 18 April 2016

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.

scientific article published on 30 March 2018

Targeting tauopathy with engineered tau-degrading intrabodies

scientific article published on 22 October 2019

Task-evoked fMRI changes in attention networks are associated with preclinical Alzheimer's disease biomarkers

scientific article published on 29 January 2015

Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers

scientific article published on 01 April 2019

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease

scientific article

Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury

scientific article

Tau: From research to clinical development

scientific article published on 3 May 2016

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

scientific article published on July 2011

The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice.

scientific article

The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers

scientific article

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

scientific article

The Ultrastructural Identity of Alzheimer's Pathology: Lessons from Animal Models

scientific article published on May 2014

The bad seed in Alzheimer's disease

scientific article

The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation

scientific article published on 25 September 2014

The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy

scientific article

The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment

scientific article

The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

scientific article

The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain

scientific article published on 24 February 2012

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

scientific article published on 11 May 2005

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells

scientific article published on 21 October 2008

The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development

scientific article published on 01 February 1997

The microbiome: A target for Alzheimer disease?

scientific article published on 01 October 2019

The modulating effect of mechanical changes in lipid bilayers caused by apoE-containing lipoproteins on Aβ induced membrane disruption

scientific article

The molecular genetics of Down syndrome

scientific article published on January 1, 1992

The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging

scientific article published on 10 June 2016

The role of apolipoprotein E in Alzheimer's disease

scientific article

The search for antecedent biomarkers of Alzheimer's disease.

scientific article

The sleep-wake cycle and Alzheimer's disease: what do we know?

scientific article

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

scientific article

The utility of intraindividual variability in selective attention tasks as an early marker for Alzheimer's disease

scientific article

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

scientific article

Time savings--realized and potential--and fair compensation for community health workers in Kenyan health facilities: a mixed-methods approach ⬇️

scientific article

Toward a multifactorial model of Alzheimer disease

scientific article published on 20 January 2012

Trans-cellular propagation of Tau aggregation by fibrillar species

scientific article

Transgenic mouse brain histopathology resembles early Alzheimer's disease

scientific article published in May 1994

Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation

scientific article published on 21 February 2013

Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains

scientific article published on 09 July 2019

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

scientific article

Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study ⬇️

scientific article published on August 1, 2010

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

scientific article published in June 2005

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons

scientific article published on February 1995

Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer's disease

scientific article

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice

scientific article

Upward drift in cerebrospinal fluid amyloid β 42 assay values for more than 10 years

scientific article

Use of YFP to study amyloid-beta associated neurite alterations in live brain slices

scientific article published in December 2003

Using the A/T/N Framework to Examine Driving in Preclinical AD

scientific article published on 02 May 2018

Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels

scientific article

Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition

scholarly article

Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease

scientific article

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.

scientific article published on 9 May 2018

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

scientific article

YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease

scientific article

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

scientific article published on 13 November 2008

microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain

scientific article

p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF

scientific article published on September 1, 1992

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