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List of works by Steven G. Younkin

18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease

scientific article published on 21 February 2008

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

scientific article published in March 2002

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

scientific article published on March 2016

African American exome sequencing identifies potential risk variants at Alzheimer disease loci

scientific article

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

scientific article

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform

scientific article

Association and heterogeneity at the GAPDH locus in Alzheimer's disease

scientific article

Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels

scientific article

Association of common KIBRA variants with episodic memory and AD risk

scientific article

Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease

scientific article published in March 2007

Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline

scientific article

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

scientific article

BRI2 (ITM2b) inhibits Abeta deposition in vivo

scientific article

Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides.

scientific article published on 17 May 2017

Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants

scientific article

Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein

scientific article

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

scientific article published in February 2002

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

scientific article

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease

scientific article

Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity

scientific article published in March 2008

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

scientific article

Effect of leuprolide on serum amyloid-β peptide levels and memory in patients with prostate cancer with biochemical recurrence.

scientific article published in January 2013

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

scientific article

Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene

scientific article published on 22 December 2004

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

scientific article

Fine mapping of the -T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees ⬇️

scientific article published on October 14, 2003

Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease

scientific article

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

scientific article

Genetic background regulates -amyloid precursor protein processing and -amyloid deposition in the mouse ⬇️

scientific article published on September 23, 2003

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

scientific article (publication date: 15 November 2010)

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease

scientific article

Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).

scientific article

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease

scientific article

Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias

scientific article

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scientific article

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma

scientific article

Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

scientific article

Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression

scientific article published on 14 July 2004

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

scientific article published on 4 February 2013

Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease

scientific article

Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

scholarly article

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).

scientific article

Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease

scientific article

Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology

scientific article

Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice.

scientific article published in July 2005

Meta-analysis of the association between variants in SORL1 and Alzheimer disease

scientific article

Multiple insulin degrading enzyme variants alter in vitro reporter gene expression

scientific article

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

scientific article (publication date: 15 January 2004)

NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide.

scientific article

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

scientific article

Peptide Nucleic Acids Targeted to the Amyloid Precursor Protein ⬇️

scientific article published on January 1, 2003

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

scientific article

Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study

scientific article

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

Rarity of the Alzheimer disease-protective APP A673T variant in the United States

scientific article

Replication of CLU, CR1, and PICALM associations with alzheimer disease.

scientific article

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

scientific journal article

Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice

scientific article published on 7 June 2007

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta

scientific article

Serum creatinine levels correlate with plasma amyloid Beta protein

scientific article published in July 2002

TREM2 Variants in Alzheimer's Disease ⬇️

scientific article published on November 14, 2012

Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

scientific article published on January 2013

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

scientific article

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice

scientific article published in August 2004

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

scientific article

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

scientific article

Using peptide nucleic acids as gene-expression modifiers to reduce beta-amyloid levels

scientific article

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