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List of works by Luca A Lotta

A Systematic Review of Biomarkers and Risk of Incident Type 2 Diabetes: An Overview of Epidemiological, Prediction and Aetiological Research Literature

scientific article

A cross-platform approach identifies genetic regulators of human metabolism and health

scientific article published on 07 January 2021

ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura

scientific article

Addressing the complexity of cardiovascular disease by design

scientific article published on 14 January 2011

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis

scientific article published on October 2016

Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort

scientific article published on 18 September 2012

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

scientific article

B and T lymphocytes in acquired Thrombotic Thrombocytopenic Purpura during disease remission

article published in 2011

Case report: use of thienopyridines in a patient with acquired idiopathic thrombotic thrombocytopenic purpura

scientific article published on 01 October 2012

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity

scientific article

Definitions of Metabolic Health and Risk of Future Type 2 Diabetes in BMI Categories: A Systematic Review and Network Meta-analysis

scientific article

Different clinical severity of first episodes and recurrences of thrombotic thrombocytopenic purpura

scientific article

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Drop of residual plasmatic activity of ADAMTS13 to undetectable levels during acute disease in a patient with adult-onset congenital thrombotic thrombocytopenic purpura

scientific article

Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism

scientific article published on 10 May 2010

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

scientific article

Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study

scientific article published on 10 September 2019

Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis

scientific article

FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients

scientific article

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

scientific article published on 26 April 2016

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

scientific article

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

scientific article published on 13 June 2018

Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease

scientific article published on 22 September 2020

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

scientific article published on 09 January 2020

Genome-wide association studies in atherothrombosis

scientific article published on 16 December 2009

Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase.

scientific article

Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes

scientific article

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

scientific article

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

scientific article published on 12 July 2017

Measurement and prevalence of circulating ADAMTS13-specific immune complexes in autoimmune thrombotic thrombocytopenic purpura.

scientific article

Measurement of anti-ADAMTS13 neutralizing autoantibodies: a comparison between CBA and FRET assays

scientific article published on 01 July 2012

Next-Generation Sequencing and In Vitro Expression Study of ADAMTS13 Single Nucleotide Variants in Deep Vein Thrombosis

scientific article

Next-generation sequencing study finds an excess of rare, coding single-nucleotide variants of ADAMTS13 in patients with deep vein thrombosis.

scientific article

No association between chromosome 12p13 single nucleotide polymorphisms and early-onset ischemic stroke

scientific article published on 21 May 2010

Non-invasive tool for foetal sex determination in early gestational age.

scientific article published on 15 April 2011

PCSK9 inhibition and type 2 diabetes

scientific article published on 14 September 2017

Pathogenesis and treatment of acquired idiopathic thrombotic thrombocytopenic purpura ⬇️

scientific article published on September 1, 2010

Plasma ADAMTS-13 levels and the risk of myocardial infarction: an individual patient data meta-analysis.

scientific article

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease

scientific article published in August 2017

Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations

scientific article published on 17 November 2020

Platelet reactive conformation and multimeric pattern of von Willebrand factor in acquired thrombotic thrombocytopenic purpura during acute disease and remission.

scientific article

Pregnancy complications in acquired thrombotic thrombocytopenic purpura: a case-control study.

scientific article

Preoperative hematocrit concentration and the risk of stroke in patients undergoing isolated coronary-artery bypass grafting

scientific article published on 30 April 2013

Prevalence of disease and relationships between laboratory phenotype and bleeding severity in platelet primary secretion defects.

scientific article

Prothrombin Mutation Conveying Antithrombin Resistance ⬇️

scientific article published on September 13, 2012

Raised haematocrit concentration and the risk of death and vascular complications after major surgery.

scientific article published in July 2013

Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura

scientific article

Single Nucleotide Variant rs2232710 in the Protein Z-Dependent Protease Inhibitor (ZPI, SERPINA10) Gene Is Not Associated with Deep Vein Thrombosis

scientific article

Smoking and the risk of mortality and vascular and respiratory events in patients undergoing major surgery

scientific article published in August 2013

The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis

scientific article published on 16 October 2020

The emerging concept of residual ADAMTS13 activity in ADAMTS13-deficient thrombotic thrombocytopenic purpura

scientific article

Thrombotic microangiopathy without renal involvement: two novel mutations in complement-regulator genes

scientific article

Treatment of chronic hepatitis C with pegylated interferon-α in a patient with recurrent autoimmune thrombotic thrombocytopenic purpura.

scientific article published on 29 October 2012

Whole-exome sequencing to identify genetic risk variants underlying inhibitor development in severe hemophilia A patients

scientific article

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