List of works - Pierre Dourlen

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

scientific article published on 02 June 2016

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

scientific article

Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival.

scientific article published on 26 July 2012

Drosophila models of tauopathies: what have we learned?

scientific article

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

scientific article

ER stress inhibits neuronal death by promoting autophagy

scientific article

ER stress protects from retinal degeneration

scientific article published on 02 April 2009

Fatty acid transport proteins in disease: New insights from invertebrate models

scientific article published on 25 September 2015

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.

scientific article

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

scientific article

Identification of Tau Toxicity Modifiers in the Drosophila Eye.

scientific article published in January 2017

In vivo assessment of neuronal cell death in Drosophila.

scientific article published in January 2015

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

scientific article

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

article

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

scientific article published on 10 September 2018

Pin1 allows for differential Tau dephosphorylation in neuronal cells

scientific article published on 11 May 2006

TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila

scientific article published on 17 January 2013

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker

scientific article published on 25 August 2012

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain

scientific article published on 23 September 2015

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

scientific article published on 08 January 2022

The Tomato/GFP-FLP/FRT method for live imaging of mosaic adult Drosophila photoreceptor cells

scientific article published on 20 September 2013

The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

scientific article published on 13 April 2019

The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease

scientific journal article

Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila

scientific article

List of works by Pierre Dourlen

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival.

Drosophila models of tauopathies: what have we learned?

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

ER stress inhibits neuronal death by promoting autophagy

ER stress protects from retinal degeneration

Fatty acid transport proteins in disease: New insights from invertebrate models

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

Identification of Tau Toxicity Modifiers in the Drosophila Eye.

In vivo assessment of neuronal cell death in Drosophila.

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

Pin1 allows for differential Tau dephosphorylation in neuronal cells

TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

The Tomato/GFP-FLP/FRT method for live imaging of mosaic adult Drosophila photoreceptor cells

The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease

Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila

Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals