List of works - Jie Zhou

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

scientific article published on 21 July 2015

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis

scientific article published on 24 September 2013

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

scientific article published on 22 July 2015

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

scientific article

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.

scientific article published on 7 March 2014

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.

scientific article published on 22 February 2016

D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice

scientific article

A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection

scientific article

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

scientific article

Selective functional deficit in dendritic cell--T cell interaction is a crucial mechanism in chronic hepatitis B virus infection.

scientific article published in May 2004

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus

scientific article published on 3 August 2016

Infection of bat and human intestinal organoids by SARS-CoV-2

scientific article published on 13 May 2020

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.

scientific article published on 25 February 2016

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

scientific article published in Journal of Biological Chemistry

Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population

article

Differentiated human airway organoids to assess infectivity of emerging influenza virus

article published in the Proceedings of the National Academy of Sciences of the United States of America

Surfactant protein B gene polymorphism is associated with severe influenza

scientific article

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

scientific article published in Nature Communications

CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry

scientific article published on 22 April 2011

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis

scientific article

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase

scientific article published on 21 November 2015

A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.

scientific article

Requirement of CRTC1 coactivator for hepatitis B virus transcription

scientific article published on 9 October 2014

Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection.

scientific article

Host genes and influenza pathogenesis in humans: an emerging paradigm

scientific article published on June 14, 2015

Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice

scientific article

Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription

scientific article

PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammals

scientific article

Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus.

scientific article

Receptor binding and transmission studies of H5N1 influenza virus in mammals

scientific article published on December 18, 2013

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza.

scientific article

Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts

scientific article published on 12 August 2016

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

scientific article published on 17 January 2019

Identification and characterization of GLDC as host susceptibility gene to severe influenza

article

Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface.

scientific article

Inhibitors of Influenza A Virus Polymerase

scientific article published on 22 January 2018

Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern

scientific article published on 11 April 2016

PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs

scientific article

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

scientific article published on 28 August 2020

Complete genome sequences of one human respiratory syncytial antigenic group a virus from china and its four mouse-adapted isolates

scientific article

Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.

scientific article

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

Establishment of a lethal aged mouse model of human respiratory syncytial virus infection

scientific article published on 29 November 2018

Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids

scientific article published on 3 November 2025

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

scientific article published on 16 July 2025

Altered host protease determinants for SARS-CoV-2 Omicron

scientific article published on 20 January 2023

Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction

scientific article published on 30 December 2024

List of works by Jie Zhou

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.

D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice

A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

Selective functional deficit in dendritic cell--T cell interaction is a crucial mechanism in chronic hepatitis B virus infection.

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus

Infection of bat and human intestinal organoids by SARS-CoV-2

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Surfactant protein B gene polymorphism is associated with severe influenza

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase

A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.

Requirement of CRTC1 coactivator for hepatitis B virus transcription

Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection.

Host genes and influenza pathogenesis in humans: an emerging paradigm

Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice

Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription

PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammals

Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus.

Receptor binding and transmission studies of H5N1 influenza virus in mammals

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza.

Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

Identification and characterization of GLDC as host susceptibility gene to severe influenza

Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface.

Inhibitors of Influenza A Virus Polymerase

Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern

PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

Complete genome sequences of one human respiratory syncytial antigenic group a virus from china and its four mouse-adapted isolates

Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

Establishment of a lethal aged mouse model of human respiratory syncytial virus infection

Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

Altered host protease determinants for SARS-CoV-2 Omicron

Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction

Attenuated replication and pathogenesis of SARS-CoV-2 B.1.1.529 Omicron

Emerging SARS-CoV-2 variants expand species tropism to rodents